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  • 1
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    Characteristics of Progesterone Changes in Women with Subtle Progesterone Rise in Recombinant Follicle-Stimulating Hormone and Gonadotropin-Releasing Hormone Antagonist Cycle
    S. Karger AG ; 2010
    In:  Gynecologic and Obstetric Investigation Vol. 70, No. 1 ( 2010), p. 64-68
    Details
    In: Gynecologic and Obstetric Investigation, S. Karger AG, Vol. 70, No. 1 ( 2010), p. 64-68
    Abstract: 〈 i 〉 Background: 〈 /i 〉 To assess the characteristics of progesterone (Prog) changes in women with a subtle Prog rise in recombinant follicle-stimulating hormone (r-FSH) and GnRH antagonist cycles. 〈 i 〉 Methods: 〈 /i 〉 We enrolled 233 patients undergoing controlled ovarian hyperstimulation with r-FSH and GnRH antagonist for IVF or ICSI. A subtle Prog rise 1 day before hCG administration was defined as a Prog value of ≧1.2 ng/ml. 〈 i 〉 Results: 〈 /i 〉 100 of 233 cycles (42.9%) showed a subtle Prog rise in this study. The mean serum Prog levels and area under curve (AUC) in the group with Prog ≧1.2 ng/ml was significantly higher than that in the Prog 〈 1.2 ng/ml group on cycle day 8 (1.17 ± 0.4 and 0.80 ± 0.3 ng/ml, respectively, for Prog level, p = 0.003; 571 ± 123 and 763 ± 250 for AUC, p = 0.001), and remained significantly higher until the day of hCG administration. Moreover, 55% of the patients on cycle day 9, 65% on cycle day 10, 75% on cycle day 11 and 85% on cycle day 12 in the Prog ≧1.2 ng/ml group have a serum Prog level of ≧1.2 ng/ml. 〈 i 〉 Conclusion: 〈 /i 〉 A subtle Prog rise may occur as early as cycle day 8 in r-FSH/GnRH antagonist cycles.
    Type of Medium: Online Resource
    ISSN: 0378-7346 , 1423-002X
    URL: Article
    DOI: 10.1159/000290062
    RVK:
    XA 45603
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2010
    detail.hit.zdb_id: 1482695-1
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  • 2
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    Rectal Villous Adenoma with McKittrick-Wheelock Syndrome: Report of a Rare Case
    S. Karger AG ; 2013
    In:  Visceral Medicine Vol. 29, No. 1 ( 2013), p. 55-58
    Details
    In: Visceral Medicine, S. Karger AG, Vol. 29, No. 1 ( 2013), p. 55-58
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 McKittrick-Wheelock syndrome mostly results from colorectal villous adenoma and is characterized by dehydration, hyponatremia, hypokalemia, and prerenal azotemia. 〈 b 〉 〈 i 〉 Case Report: 〈 /i 〉 〈 /b 〉 We report the case of an 84-year-old patient with rectal villous adenoma, presenting with chronic mucous diarrhea for 2 years and subsequent prerenal azotemia. After fluid and electrolyte replenishment, the patient underwent proctectomy and recovered completely. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 According to a review of the literature, we suggest that surgical resection can achieve a complete recovery.
    Type of Medium: Online Resource
    ISSN: 2297-4725 , 2297-475X
    URL: Article
    DOI: 10.1159/000348494
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2013
    detail.hit.zdb_id: 2850734-4
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  • 3
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    Effects and Safety of Intracoronary Thrombectomy Using Transradial Application of the PercuSurge Distal Balloon Protection System in Patients with Early or Recent Myocardial Infarction
    S. Karger AG ; 2004
    In:  Cardiology Vol. 102, No. 4 ( 2004), p. 206-214
    Details
    In: Cardiology, S. Karger AG, Vol. 102, No. 4 ( 2004), p. 206-214
    Abstract: 〈 i 〉 Background: 〈 /i 〉 Distal embolization and no reflow are likely during primary percutaneous coronary intervention (PCI) on the large infarct-related artery (IRA), which mostly contains high-burden thrombus formation (HBTF) and plaque burden. Mechanical devices to prevent distal atheroembolism may be of importance for preserving reperfusion and microvascular integrity in IRA. 〈 i 〉 Methods and Results: 〈 /i 〉 Between May 2002 and December 2002, transradial application (TRA) of the PercuSurge GuardWire™ device with 7-french arterial sheath was performed in 39 consecutive patients who experienced early ( 〉 12 h and ≤7 days) or recent ( 〉 7 days and 〈 14 days) myocardial infarction (MI) associated with large IRA (vessel size ≧3.5 mm with HBTF; group 1). Between January 2001 and April 2002, 64 consecutive patients who had early or recent MI associated with HBTF in IRA of a vessel size ≧3.5 mm received TRA of PCI with adjunctive tirofiban therapy but without using the adjunctive PercuSurge GuardWire device (group 2). The angiographic and clinical outcomes of both groups were compared in a chronologically consecutive manner. The procedural success rate and post-PCI myocardial blush grades were significantly higher in group 1 than in group 2 patients (all p values 〈 0.05), whereas a combined incidence of vascular and bleeding complications and 30-day major adverse cardiac events (defined as death, reinfarction and repeated PCI of IRA) were significantly higher in group 2 than in group 1 patients (all p values 〈 0.05). 〈 i 〉 Conclusions: 〈 /i 〉 Our data suggested that TRA using the PercuSurge GuardWire device during PCI for patients with early or recent MI and HBTF in IRA was safe and feasible. This mechanical device provided more additional benefit to patients in this clinical setting than a combination of conventional PCI and tirofiban therapy.
    Type of Medium: Online Resource
    ISSN: 0008-6312 , 1421-9751
    URL: Article
    DOI: 10.1159/000081012
    RVK:
    XA 36200
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2004
    detail.hit.zdb_id: 1482041-9
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  • 4
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    Balance between Plasma Levels of Tumor Necrosis Factor-α and Interleukin-10 in Rheumatic Mitral Stenosis
    S. Karger AG ; 2005
    In:  Cardiology Vol. 104, No. 4 ( 2005), p. 171-175
    Details
    In: Cardiology, S. Karger AG, Vol. 104, No. 4 ( 2005), p. 171-175
    Abstract: The study population consisted of 16 patients with rheumatic mitral stenosis undergoing percutaneous transluminal mitral valvuloplasty (group 1). The plasma levels of tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10) in the femoral vein and the right and left atria before valvuloplasty were determined by ELISA. Additionally, we measured plasma concentrations of TNF-α and IL-10 in the venous blood obtained from 19 control patients, including 12 healthy volunteers in sinus rhythm (group 2) and 7 patients in permanent lone atrial fibrillation (group 3). The venous plasma levels of TNF-α were significantly elevated in group 1 patients compared with group 2 patients (p 〈 0.002). Correlation analysis demonstrated that there was a significantly direct relationship between the plasma TNF-α and IL-10 concentrations in the left atrial, right atrial and peripheral venous blood (p 〈 0.008, r = 0.640; p 〈 0.04, r = 0.538; p 〈 0.03, r = 0.571, respectively). In conclusion, the plasma concentrations of TNF-α of patients with rheumatic mitral stenosis were significantly higher than those of healthy volunteers. In addition, there was a significantly direct relationship between the soluble TNF-α and IL-10 concentrations in the atrial and peripheral venous blood, indicating a balance between circulating TNF-α and IL-10 levels in patients with rheumatic mitral stenosis.
    Type of Medium: Online Resource
    ISSN: 0008-6312 , 1421-9751
    URL: Article
    DOI: 10.1159/000088104
    RVK:
    XA 36200
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2005
    detail.hit.zdb_id: 1482041-9
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  • 5
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    Increased Levels of Total 〈b〉〈i〉p〈/i〉〈/b〉-Cresylsulfate Are Associated with Pruritus in Patients with Chronic Kidney Disease
    S. Karger AG ; 2016
    In:  Dermatology Vol. 232, No. 3 ( 2016), p. 363-370
    Details
    In: Dermatology, S. Karger AG, Vol. 232, No. 3 ( 2016), p. 363-370
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Pruritus is a common and distressing symptom that affects patients with chronic kidney disease (CKD). Indoxyl sulfate (IS) and 〈 i 〉 p 〈 /i 〉 -cresylsulfate (PCS) are uremic toxins with similar protein binding, dialytic clearance, and proinflammatory features. Pruritus in CKD may correlate better with uremic toxins than the glomerular filtration rate (GFR), suggesting that uremic toxins either in the central nervous system or peripherally may play an important role in the pathophysiology. 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 We sought to investigate the potential contribution of serum total IS and PCS to the pathogenesis of pruritus. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 The serum levels of total IS and PCS concentrations were measured in all patients by using the Ultra Performance LC System. The characteristics of pruritus were assessed using a visual analog scale score and an interview questionnaire. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Among the 320 CKD patients, 35% had pruritus. The patients with pruritus were older and had a higher frequency of diabetes mellitus, higher uric acid, calcium, phosphorus, creatinine, high-sensitivity C-reactive protein, and total IS and PCS levels, and lower albumin concentrations and estimated GFR (eGFR) than those without pruritus. Increasing concentrations of total PCS were independently and significantly associated with pruritus. Multiple logistic regression analysis revealed total PCS as an independent association factor for pruritus, even after full adjustment of known biomarkers. Furthermore, serum total PCS levels were positively associated with calcium, phosphorus, blood urea nitrogen, creatinine, and white blood cell count, and negatively associated with eGFR, hemoglobin, and hematocrit. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Our results indicate that total PCS may play a role in the pathogenesis of pruritus.
    Type of Medium: Online Resource
    ISSN: 1018-8665 , 1421-9832
    URL: Article
    DOI: 10.1159/000445429
    RVK:
    XA 37700
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2016
    detail.hit.zdb_id: 1482189-8
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  • 6
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    Asymmetric Involvement in Sporadic Creutzfeldt-Jakob Disease: Clinical, Brain Imaging, and Electroencephalographic Studies
    S. Karger AG ; 2010
    In:  European Neurology Vol. 64, No. 2 ( 2010), p. 74-79
    Details
    In: European Neurology, S. Karger AG, Vol. 64, No. 2 ( 2010), p. 74-79
    Abstract: 〈 i 〉 Objective: 〈 /i 〉 To ascertain the characteristics of patients with sporadic Creutzfeldt-Jakob disease (CJD) and to determine the findings of electroencephalography (EEG) and brain magnetic resonance imaging (MRI). 〈 i 〉 Methods: 〈 /i 〉 We pooled patients at a hospital from 2000 to 2008, and classified them according to WHO diagnostic criteria as having probable or possible CJD. We retrospectively analyzed their clinical manifestations, brain MRI, and EEG findings to evaluate correlations among them. 〈 i 〉 Results: 〈 /i 〉 In this study, 12 probable and 4 possible CJD patients were identified. Ten patients with probable CJD had asymmetric manifestations with hemiparesis, focal myoclonus, dystonia or apraxia; 9 had clinical manifestations mimicking the corticobasal syndrome. In contrast, neurological examinations did not show asymmetric signs in 4 patients with possible CJD. EEG showed a typical periodic sharp wave complex (PSWC) in 12 patients with probable CJD; most of them had bright signal intensity on diffusion-weighted imaging of the cortex and/or basal ganglia. There was a high tendency for asymmetric clinical manifestations that correlated with the presentation of PSWC and cortical lesions observed on the brain MRI scan. 〈 i 〉 Conclusions: 〈 /i 〉 Our study indicates that asymmetric extrapyramidal symptoms/signs, in clinical features with characteristic abnormalities on MRI and EEG findings, might contribute to early diagnosis of sporadic CJD.
    Type of Medium: Online Resource
    ISSN: 0014-3022 , 1421-9913
    URL: Article
    DOI: 10.1159/000315148
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2010
    detail.hit.zdb_id: 1482237-4
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  • 7
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    Online Resource
    Serum Adiponectin Levels Increase after Human Chorionic Gonadotropin Treatment during in vitro Fertilization
    S. Karger AG ; 2006
    In:  Gynecologic and Obstetric Investigation Vol. 62, No. 2 ( 2006), p. 61-65
    Details
    In: Gynecologic and Obstetric Investigation, S. Karger AG, Vol. 62, No. 2 ( 2006), p. 61-65
    Abstract: 〈 i 〉 Aims: 〈 /i 〉 To determine whether or not serum adiponectin concentrations are influenced by ovarian hyperstimulation during in vitro fertilization (IVF). 〈 i 〉 Methods: 〈 /i 〉 This study involved 52 women who were participating in IVF-ET cycles. Adiponectin levels in serum were determined by radioimmunoassay and compared. 〈 i 〉 Results: 〈 /i 〉 Serum adiponectin levels fell from Day-basal to Day-hCG (p = 0.047), and then rose on Day-OR and again on Day-7ET (p 〈 0.001; p 〈 0.001). Estradiol levels on Day-hCG were significantly and positively correlated with serum adiponectin levels on Day-OR and Day-7ET (r = 0.325, p = 0.019; r = 0.372, p = 0.007). Progesterone levels on Day-OR positively correlated with serum adiponectin levels on Day-basal (r = 0.278, p = 0.046). There was also a positive correlation between progesterone levels on Day-7ET and serum adiponectin levels on Day-OR (r = 0.289, p = 0.038). Multiple linear regression analysis revealed that adiponectin levels on Day-OR and Day-7ET were negatively correlated with age and body mass index after adjustment was made for concomitant diseases. 〈 i 〉 Conclusions: 〈 /i 〉 To sum up, following gonadotropin treatment, serum adiponectin levels decrease as a result of the negative effect of high estradiol levels on adiponectin production. Conversely, serum adiponectin levels increase following human chorionic gonadotropin treatment.
    Type of Medium: Online Resource
    ISSN: 0378-7346 , 1423-002X
    URL: Article
    DOI: 10.1159/000092260
    RVK:
    XA 45603
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2006
    detail.hit.zdb_id: 1482695-1
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  • 8
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    Are Both Psychological and Physical Dimensions in Health-Related Quality of Life Associated with Mortality in Hemodialysis Patients: A 7-Year Taiwan Cohort Study
    S. Karger AG ; 2010
    In:  Blood Purification Vol. 30, No. 2 ( 2010), p. 98-105
    Details
    In: Blood Purification, S. Karger AG, Vol. 30, No. 2 ( 2010), p. 98-105
    Abstract: 〈 i 〉 Background: 〈 /i 〉 Psychological depression and physical disability are closely correlated in hemodialysis patients. A retrospective cohort study was conducted to examine the independent association of physical and psychological functioning with mortality in a hemodialysis cohort in Taiwan. 〈 i 〉 Methods: 〈 /i 〉 A total of 888 stable hemodialysis patients were included. Patients completed two questionnaires: the 36-item Short Form Health Survey Questionnaire (SF-36, Taiwan Standard Version 1.0) and the Beck Depression Inventory (BDI, Chinese Version). Mortality outcomes were recorded for a seven-year follow-up period. 〈 i 〉 Results: 〈 /i 〉 There were 303 deaths recorded. BDI scores were inversely related to all health-related quality of life (HRQoL) domains (p 〈 0.001). In the Cox-proportional hazard model, only poor physical dimension of HRQoL was independently associated with higher mortality. 〈 i 〉 Conclusion: 〈 /i 〉 Poor physical dimension in HRQoL is a strong predictor of mortality among hemodialysis patients in Taiwan. Psychological depression is closely correlated with poor HRQoL but does not predict mortality.
    Type of Medium: Online Resource
    ISSN: 0253-5068 , 1421-9735
    URL: Article
    DOI: 10.1159/000319002
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2010
    detail.hit.zdb_id: 1482025-0
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  • 9
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    Association between the Ser9Gly Polymorphism of the Dopamine D3 Receptor Gene and Tardive Dyskinesia in Chinese Schizophrenic Patients
    S. Karger AG ; 2001
    In:  Neuropsychobiology Vol. 44, No. 2 ( 2001), p. 95-98
    Details
    In: Neuropsychobiology, S. Karger AG, Vol. 44, No. 2 ( 2001), p. 95-98
    Abstract: It has been suggested that dopamine D3 receptor (DRD3) may have important implications for antipsychotic-induced tardive dyskinesia (TD). Previous studies have demonstrated an association between a serine to glycine polymorphism in the first exon of the DRD3 gene and TD; however, the results have been inconsistent. Therefore, we have replicated these studies using a Chinese sample population. A total of 115 schizophrenic patients from chronic wards were assessed for TD severity using the Abnormal Involuntary Movements Scale (AIMS) and were subsequently genotyped for the DRD3 polymorphism. The mean AIMS score for patients carrying the heterozygote (DRD3 〈 sub 〉 ser-gly 〈 /sub 〉 ) was significantly greater than for those with the homozygotes (DRD3 〈 sub 〉 ser-ser 〈 /sub 〉 and DRD3 〈 sub 〉 gly-gly 〈 /sub 〉 ). Our results are in line with a previous report, the results of which suggest that the presence of the DRD3 〈 sub 〉 ser-gly 〈 /sub 〉 genotype may be a risk factor for the development of TD in patients treated with antipsychotics.
    Type of Medium: Online Resource
    ISSN: 0302-282X , 1423-0224
    URL: Article
    DOI: 10.1159/000054924
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2001
    detail.hit.zdb_id: 1483094-2
    SSG: 5,2
    SSG: 15,3
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  • 10
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    Baseline Mac-2 Binding Protein Glycosylation Isomer Level Stratifies Risks of Hepatocellular Carcinoma in Chronic Hepatitis B Patients with Oral Antiviral Therapy
    S. Karger AG ; 2020
    In:  Liver Cancer Vol. 9, No. 2 ( 2020), p. 207-220
    Details
    In: Liver Cancer, S. Karger AG, Vol. 9, No. 2 ( 2020), p. 207-220
    Abstract: 〈 b 〉 〈 i 〉 Background and Aims: 〈 /i 〉 〈 /b 〉 Mac-2 binding protein glycosylation isomer (M2BPGi) is a novel biomarker correlating with liver fibrosis stages. However, little is known about how it predicts risks of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients receiving long-term antiviral treatment. 〈 b 〉 〈 i 〉 Materials and Methods: 〈 /i 〉 〈 /b 〉 The study contained 2 parts. The first part was to explore whether M2BPGi could be an HCC predictor in 899 CHB patients receiving long-term entecavir therapy. The second part was to validate the findings in an independent cohort of 384 on-treatment CHB patients with more severe liver disease. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 In the discovery cohort, there were 64 patients developing HCC within an average follow-up of 7.01 years. Our data showed that M2BPGi level was positively associated with HCC development. When stratifying the patients by an M2BPGi level of 1.73 (the third quartile), the high M2BPGi group was shown to have an increased HCC risk compared to the low M2BPGi group with hazard ratio of 5.80 (95% CI 3.50–9.60). Furthermore, we found that the M2BPGi level complements PAGE-B score, a well-validated HCC prediction model, to predict HCC development. Lastly, the cutoff was validated in the independent cohort, especially those with an intermediate PAGE-B score. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 In CHB patients receiving long-term antiviral treatment, serum M2BPGi level not only serves as an independent HCC predictor but also complements PAGE-B in stratifying HCC risks.
    Type of Medium: Online Resource
    ISSN: 2235-1795 , 1664-5553
    URL: Article
    DOI: 10.1159/000504650
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2020
    detail.hit.zdb_id: 2666925-0
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