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  • 1
    Online Resource
    Online Resource
    Compassionate Use of Linezolid for Adult Taiwanese Patients with Bone and Joint Infections
    S. Karger AG ; 2010
    In:  Chemotherapy Vol. 56, No. 6 ( 2010), p. 429-435
    Details
    In: Chemotherapy, S. Karger AG, Vol. 56, No. 6 ( 2010), p. 429-435
    Abstract: 〈 i 〉 Background: 〈 /i 〉 Compassionate use of linezolid for bone and joint infections has been reported and hematological adverse reactions are a cause for concern. A similar experience in Asian people has not been reported. 〈 i 〉 Methods: 〈 /i 〉 Adult cases that received linezolid for bone and joint infections at 3 Taiwanese medical centers from 2002 to 2006 were analyzed. We investigated factors associated with treatment outcome and hematological adverse reactions. 〈 i 〉 Results: 〈 /i 〉 Of the 51 cases that received linezolid for more than 3 days, 41 (80.4%) had a favorable outcome and 10 had a failed outcome. Based on univariate analysis, patients with renal/urinary tract diseases, gastrointestinal diseases, higher WBC counts, a higher alanine aminotransferase level, or a higher creatinine level prior to linezolid treatment were significantly associated with a failed outcome. Based on multivariate analysis, underlying gastrointestinal disease was the only significant factor for a failed outcome. Six patients stopped linezolid use due to adverse reactions. A failed outcome was significantly associated with anemia caused by linezolid. 〈 i 〉 Conclusion: 〈 /i 〉 Linezolid is an effective salvage agent for bone and joint infections. However, adverse effects, especially hematological reactions, may cause drug discontinuation.
    Type of Medium: Online Resource
    ISSN: 0009-3157 , 1421-9794
    URL: Article
    DOI: 10.1159/000317752
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2010
    detail.hit.zdb_id: 1482111-4
    SSG: 15,3
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  • 2
    Online Resource
    Online Resource
    Safety and Efficacy of Cefpirome in Comparison with Ceftazidime in Chinese Patients with Sepsis due to Bacterial Infections
    S. Karger AG ; 2000
    In:  Chemotherapy Vol. 46, No. 5 ( 2000), p. 371-378
    Details
    In: Chemotherapy, S. Karger AG, Vol. 46, No. 5 ( 2000), p. 371-378
    Abstract: 〈 i 〉 Background: 〈 /i 〉 The safety and efficacy of cefpirome (CPM), a fourth-generation cephalosporin, has not yet been studied in an Asian population. 〈 i 〉 Methods: 〈 /i 〉 Sixty-nine adult Chinese patients with sepsis due to bacterial infections were enrolled in the study and randomly assigned to receive CPM (2 g i.v. every 12 h) or ceftazidime (2 g i.v. every 8 h). 〈 i 〉 Results: 〈 /i 〉 Both groups were comparable in terms of demographic, clinical and microbiological features. The causative pathogen was 〈 i 〉 Escherichia coli 〈 /i 〉 or 〈 i 〉 Klebsiella pneumoniae 〈 /i 〉 in the majority of microbiologically documented cases. The rates of clinical response (94 vs. 94%) and bacteriological response (65 vs. 68%) were similar in both groups. Similar adverse events, including rashes, gastrointestinal upset and asymptomatic elevation of hepatic enzymes, occurred in a minority of patients in both groups. All events were self-limited after discontinuation of the drugs. 〈 i 〉 Conclusion: 〈 /i 〉 CPM is as safe and effective as ceftazidime in the treatment of sepsis due to bacterial infections in Chinese patients.
    Type of Medium: Online Resource
    ISSN: 0009-3157 , 1421-9794
    URL: Article
    DOI: 10.1159/000007311
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2000
    detail.hit.zdb_id: 1482111-4
    SSG: 15,3
    Location Call Number Limitation Availability
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  • 3
    Online Resource
    Online Resource
    Pharmacokinetics and Safety of Multiple Intravenous Doses of Daptomycin in a Taiwanese Adult Population
    S. Karger AG ; 2009
    In:  Chemotherapy Vol. 55, No. 2 ( 2009), p. 91-96
    Details
    In: Chemotherapy, S. Karger AG, Vol. 55, No. 2 ( 2009), p. 91-96
    Abstract: 〈 i 〉 Background: 〈 /i 〉 The pharmacokinetics (PK) and safety of daptomycin have not yet been studied in an adult Taiwanese population. 〈 i 〉 Methods: 〈 /i 〉 A total of 13 healthy adult Taiwanese subjects (7 males and 6 females) were enrolled to receive a 5-day course of multiple intravenous daptomycin infusions at a dose of 4 mg/kg every 24 h. Both single-dose and steady-state serum PK were assessed. 〈 i 〉 Results: 〈 /i 〉 PK evaluation showed no relevant accumulation of daptomycin based on the steady-state PK, which could be predicted from the single-dose PK. No gender effect on daptomycin, for either single- or multiple-dose PK, was observed. About 60% of the infused daptomycin was eliminated by the renal system in an unchanged form. Protein binding of daptomycin was about 93.92%. The PK parameters in healthy Taiwanese subjects were similar to those reported in healthy Caucasian subjects. No serious adverse events (AE) or deaths occurred during the study. The most frequently reported AE was leukopenia (3/19, 15.8%), followed by amblyopia (2/19, 10.5%). These AEs were considered to be mild-to-moderate in severity and resolved spontaneously. 〈 i 〉 Conclusion: 〈 /i 〉 This study demonstrated similarities between Taiwanese and Caucasian healthy subjects in the PK profiles of daptomycin, and thus the dosage regimen used in Caucasian subjects could be applied to Taiwanese.
    Type of Medium: Online Resource
    ISSN: 0009-3157 , 1421-9794
    URL: Article
    DOI: 10.1159/000192392
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2009
    detail.hit.zdb_id: 1482111-4
    SSG: 15,3
    Location Call Number Limitation Availability
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    Online Resource
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