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  • 1
    Online Resource
    Online Resource
    Relationship between Serum Vitamin D Levels and Health-Related Quality of Life in Maintenance Hemodialysis Patients
    S. Karger AG ; 2019
    In:  Blood Purification Vol. 48, No. 1 ( 2019), p. 67-75
    Details
    In: Blood Purification, S. Karger AG, Vol. 48, No. 1 ( 2019), p. 67-75
    Abstract: 〈 b 〉 〈 i 〉 Objectives: 〈 /i 〉 〈 /b 〉 Aim of the study was investigating the effect of serum vitamin D levels on health-related quality of life in hemodialysis patients. 〈 b 〉 〈 i 〉 Method: 〈 /i 〉 〈 /b 〉 One-hundred and twenty-three maintenance hemodialysis patients were enrolled in this cross-sectional study. Patients divided into 2 groups according to serum vitamin D levels. A serum 25-hydroxyvitamin D (25[OH] D) level of & #x3c; 20 ng/mL was identified as vitamin D deficiency ( 〈 i 〉 n 〈 /i 〉 = 78), and a serum level of ≥20 ng/mL was identified as normal ( 〈 i 〉 n 〈 /i 〉 = 45). Kidney Disease Quality of Life 36 (KDQOL-36) survey was used for quality of life measurement. Scores of the all of 5 subscales of KDQOL-36 were calculated. Multiple linear regression analyses were used to define independent risk factors affecting the survey. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Mean age of patients was 62 and 56% of patients were male. Mean 25(OH) D levels were 11.86 and 29.57 ng/mL, respectively, in 2 groups. There was statistically significant difference between age and Kt/V levels between 2 groups ( 〈 i 〉 p 〈 /i 〉 = 0.008 and 〈 i 〉 p 〈 /i 〉 = 0.041). Age and gender were found as significant predictors of vitamin D deficiency ( 〈 i 〉 p 〈 /i 〉 = 0.026 and 〈 i 〉 p 〈 /i 〉 = 0.021). In symptom and problem list subscale, gender and comorbidity were detected as independent risk factors ( 〈 i 〉 p 〈 /i 〉 = 0.050 and 〈 i 〉 p 〈 /i 〉 = 0.032). Comorbidity was the only independent risk factor for effect of kidney disease subscale ( 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001). Independent risk factors associated with burden of kidney disease subscale were comorbidity and serum 25 (OH) D levels ( 〈 i 〉 p 〈 /i 〉 = 0.003 and 〈 i 〉 p 〈 /i 〉 = 0.023). Serum 25(OH) D, gender, and comorbidity were independently associated with physical component summary (PCS) subscale ( 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001, 〈 i 〉 p 〈 /i 〉 = 0.008, and 〈 i 〉 p 〈 /i 〉 = 0.011). The only independently associated factor with mental component summary (MCS) was serum 25(OH) D ( 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 We first showed the relationship between serum vitamin D levels and KDQOL-36 in hemodialysis patients. Lower serum vitamin D levels were negatively associated with burden of kidney disease, PCS, and MCS subscales.
    Type of Medium: Online Resource
    ISSN: 0253-5068 , 1421-9735
    URL: Article
    DOI: 10.1159/000497242
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2019
    detail.hit.zdb_id: 1482025-0
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  • 2
    Online Resource
    Online Resource
    Biological Subtypes and Distant Relapse Pattern in Breast Cancer Patients After Curative Surgery (Study of Anatolian Society of Medical Oncology)
    S. Karger AG ; 2016
    In:  Breast Care Vol. 11, No. 4 ( 2016), p. 248-252
    Details
    In: Breast Care, S. Karger AG, Vol. 11, No. 4 ( 2016), p. 248-252
    Abstract: 〈 b 〉 〈 i 〉 Purpose: 〈 /i 〉 〈 /b 〉 The aim of the study was to investigate the association between the molecular subtypes and patterns of relapse in breast cancer patients who had undergone curative surgery. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 We retrospectively evaluated 1,350 breast cancer patients with relapses after curative surgery between 1998 and 2012 from referral centers in Turkey. Patients were divided into 4 biological subtypes according to immunohistochemistry and grade: triple negative, HER2 overexpressing, luminal A and luminal B. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The percentages of patients with luminal A, luminal B, HER2-overexpressing, and triple-negative breast cancer were 32.9% (n = 444), 34.9% (n = 471), 12.0% (n = 162), and 20.2% (n = 273), respectively. The distribution of metastases differed among the subgroups: bone (66.2% and 53.9% in luminal A and B vs. 38.9% in HER2-overexpressing and 45.1% in triple negative, p 〈 0.001), liver (40.1% in HER2-overexpressing vs. 24.5% in luminal A, 33.5% in luminal B, and 27.5% in triple negative, p 〈 0.001), lung (41.4% in triple negative and 35.2% in HER2-overexpressing vs. 30.2% and 30.6% in luminal A and B, p = 0.008) and brain (25.3% in HER2-overexpressing and 23.1% in triple negative vs. 10.1% and 15.1% in luminal A and B, p 〈 0.001). 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Organ-specific metastasis may depend on the molecular subtype of breast cancer. Tailored strategies against distant metastasis concerning the molecular subtypes in breast cancer should be considered.
    Type of Medium: Online Resource
    ISSN: 1661-3791 , 1661-3805
    URL: Article
    DOI: 10.1159/000448186
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2016
    detail.hit.zdb_id: 2205941-6
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  • 3
    Online Resource
    Online Resource
    Atrial Fibrillation Induced by Gemcitabine Treatment in a 65-Year-Old Man
    S. Karger AG ; 2007
    In:  Oncology Research and Treatment Vol. 30, No. 5 ( 2007), p. 253-255
    Details
    In: Oncology Research and Treatment, S. Karger AG, Vol. 30, No. 5 ( 2007), p. 253-255
    Type of Medium: Online Resource
    ISSN: 2296-5270 , 2296-5262
    URL: Article
    DOI: 10.1159/000100930
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2007
    detail.hit.zdb_id: 2749752-5
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  • 4
    Online Resource
    Online Resource
    Comparison of Blood Flow Velocities of the Extraocular Vessels in Patients with Pseudoexfoliation or Primary Open-Angle Glaucoma
    S. Karger AG ; 2001
    In:  Ophthalmologica Vol. 215, No. 6 ( 2001), p. 424-429
    Details
    In: Ophthalmologica, S. Karger AG, Vol. 215, No. 6 ( 2001), p. 424-429
    Abstract: 〈 i 〉 Purpose: 〈 /i 〉 To evaluate orbital blood flow velocities in patients with pseudoexfoliation glaucoma (PXG) or primary open-angle glaucoma (POAG). 〈 i 〉 Methods: 〈 /i 〉 Blood flow velocities in the ophthalmic, central retinal, and posterior ciliary arteries were evaluated by color Doppler imaging in 26 patients with PXG, 28 patients with POAG and 30 age-matched normal control subjects. The results were compared. 〈 i 〉 Results: 〈 /i 〉 Compared to the control subjects, patients with PXG showed statistically significant decreases in the mean peak systolic and end-diastolic velocities and increased mean resistive indices in all vessels except for the ophthalmic artery mean peak systolic velocity (p 〈 0.05). Patients with POAG, when compared to the control subjects, showed statistically significant decreases in the mean end-diastolic velocities and increased mean resistive indices in all vessels measured (p 〈 0.05). No statistically significant differences were found in the mean blood flow parameters between POAG and PXG. 〈 i 〉 Conclusion: 〈 /i 〉 Blood flow velocities of the retrobulbar vessels are decreased in patients with PXG. Reduced blood flow velocities may be secondary as well as contributory to exfoliative glaucomatous damage. Although there was no significant difference in the mean blood flow parameters between POAG and PXG, alterations of retrobulbar vessels might be associated with different pathogenic mechanisms of PXG.
    Type of Medium: Online Resource
    ISSN: 0030-3755 , 1423-0267
    URL: Article
    DOI: 10.1159/000050902
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2001
    detail.hit.zdb_id: 1483531-9
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  • 5
    Online Resource
    Online Resource
    Serum Uric Acid Independently Predicts Cardiovascular Events in Advanced Nephropathy
    S. Karger AG ; 2012
    In:  American Journal of Nephrology Vol. 36, No. 4 ( 2012), p. 324-331
    Details
    In: American Journal of Nephrology, S. Karger AG, Vol. 36, No. 4 ( 2012), p. 324-331
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Chronic kidney disease (CKD) is associated with increased risk for cardiovascular (CV) disease and is also associated with elevated uric acid, which is emerging as a nontraditional CV risk factor. We therefore evaluated uric acid as a risk factor for CV disease in subjects presenting to nephrologists with CKD who were not on medications known to alter endothelial function. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 303 subjects with stage 3–5 CKD were followed for a mean of 39 months (range 6–46) and assessed for fatal and nonfatal CV events. Hyperuricemia was defined as uric acid 〉 6.0 mg/dl for women and 〉 7.0 mg/dl for men. In addition to other CV risk factors, endothelial function (flow-mediated dilatation), inflammatory markers (hsCRP), and insulin resistance (HOMA index and fasting insulin levels) were included in the analysis. We evaluated the association between uric acid and flow-mediated dilatation with linear regression. The impact of uric acid on composite CV events was assessed with Cox regression analysis. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Of a total of 303 patients, 89 had normouricemia and 214 had hyperuricemia. Both fatal (32 of 214 vs. 1 of 89 subjects) and combined fatal and nonfatal (100 of 214 vs. 13 of 89 subjects) CV events were more common in subjects with hyperuricemia compared with normal uric acid levels, and this was independent of estimated glomerular filtration rate, traditional CV risk factors including diabetes, hypertension and BMI, and nontraditional risk factors (hsCRP and endothelial function). The 46-month survival rate was 98.7% in the group with low uric acid compared to 85.8% in patients with high uric acid (p 〈 i 〉 = 〈 /i 〉 0 〈 i 〉 . 〈 /i 〉 002). 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Hyperuricemia is an independent risk factor for CV events in subjects presenting with CKD who are not on medications known to alter endothelial function.
    Type of Medium: Online Resource
    ISSN: 0250-8095 , 1421-9670
    URL: Article
    DOI: 10.1159/000342390
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2012
    detail.hit.zdb_id: 1468523-1
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