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  • S. Karger AG  (3)
  • 1
    In: Psychopathology, S. Karger AG, Vol. 39, No. 5 ( 2006), p. 218-226
    Abstract: 〈 i 〉 Background: 〈 /i 〉 Few studies have explored the prevalence of delusions in the non-clinical, elderly population. In addition, the association between personality structure and delusions remains poorly investigated. The aims of the present study were, first, to explore the relation between age and the prevalence of delusion proneness and, second, to examine the association between personality and delusion proneness in young and elderly participants. 〈 i 〉 Sampling and Methods: 〈 /i 〉 A sample of young (n = 343; aged 18–30 years) and elderly (n = 183; aged 60–75 years) non-clinical participants completed the 21-item version of the Peters et al. Delusions Inventory (PDI-21), an elaborated and validated version of the Launay-Slade Hallucinations Scale, and the revised version of the NEO Personality Inventory (NEO-PI-R). 〈 i 〉 Results: 〈 /i 〉 Mean scores on the PDI-21 for the young and elderly participants were compared. An independent t test revealed that the total mean scores were significantly higher for young participants compared to elderly participants. PDI-21 items were then re-grouped into previously validated factors. Independent t tests revealed that young participants had significantly higher scores for items related to suspiciousness and persecutory ideas, thought disturbances and jealousy, grandiose ideas, paranormal beliefs and apocalyptic ideas. In contrast, elderly participants scored significantly higher than young participants on the religious ideation factor. Associations between scores on the NEO-PI-R and the PDI-21 were then examined for the two groups. For the young sample, correlational analyses revealed a significant relationship between the total score on the PDI-21 and scores on the openness, neuroticism and agreeability facets of the NEO-PI-R. For the elderly sample, correlational analyses revealed a significant relationship between the total score on the PDI-21 and the openness facet of the NEO-PI-R. 〈 i 〉 Discussion: 〈 /i 〉 Results from the study reveal that delusional ideation is a relatively common experience for both young and elderly non-clinical participants. In addition, findings are in line with studies suggesting that neuroticism and aspects related to neuroticism increase the risk for the development of psychotic symptoms such as delusions. However, it is important to mention that, because the present study includes non-clinical subjects and is a cross-sectional study, more research is needed.
    Type of Medium: Online Resource
    ISSN: 0254-4962 , 1423-033X
    RVK:
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2006
    detail.hit.zdb_id: 1483565-4
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  • 2
    Online Resource
    Online Resource
    S. Karger AG ; 2008
    In:  Neuropsychobiology Vol. 57, No. 1-2 ( 2008), p. 44-48
    In: Neuropsychobiology, S. Karger AG, Vol. 57, No. 1-2 ( 2008), p. 44-48
    Abstract: The digit span task measures the maintenance of information in short-term memory, and is one of the most widely used tests in clinical and experimental neuropsychology. Functional imaging studies have suggested a role of the right dorsolateral prefrontal cortex (DLPFC) in digit span performance. It remains unclear however, whether activation of this area is critical for task performance. Using repetitive transcranial magnetic stimulation (rTMS) over the right DLPFC in a sham-controlled design, we tested the hypothesis of the involvement of the right DLPFC in digit span task performance. We observed a significant disruption of digit span performance in healthy subjects in the real rTMS condition as compared to the sham condition. This effect of rTMS did not differ between digits forward and digits backward. Our results suggest that the right DLPFC is critical for central executive processes utilized by the digits forward and backward tasks.
    Type of Medium: Online Resource
    ISSN: 0302-282X , 1423-0224
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2008
    detail.hit.zdb_id: 1483094-2
    SSG: 5,2
    SSG: 15,3
    Location Call Number Limitation Availability
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  • 3
    In: Neuropsychobiology, S. Karger AG, Vol. 41, No. 2 ( 2000), p. 73-78
    Abstract: Circulating levels of growth hormone (GH) change during the process of aging. Decline of cognitive functioning with aging is also well established. In this study, we investigated whether insulin-like growth factor 1 (IGF-1) and the GH response to a challenge of GH-releasing hormone and GH-releasing peptide 6 were associated with age-sensitive cognitive functions, but not with functions that do not decline with aging, in 17 healthy male subjects aged between 66 and 76 years. In addition, relations with anthropometric measures were examined. Neuropsychological performance was scored on tests of variables not sensitive to aging (general knowledge, vocabulary, basic visual perception and reading ability), and of variables sensitive to aging (visuoconstructive ability, perceptual motor and mental processing speed, and verbal long-term memory). After correcting for education, the serum GH response was significantly associated with two age-sensitive cognitive tests (measures of mental processing speed), but with none of the tests not sensitive to aging. However, the direction of the association was opposite to the relation between IGF-1 and these cognitive tests: higher levels of GH response were associated with poorer cognitive performance, whereas higher levels of IGF-1 were associated with better performance. GH response, but not IGF-1, was inversely correlated with body mass index. The results are in accordance with previous research suggesting a disruption of the relation between IGF-1 and GH secretion in older age.
    Type of Medium: Online Resource
    ISSN: 0302-282X , 1423-0224
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2000
    detail.hit.zdb_id: 1483094-2
    SSG: 5,2
    SSG: 15,3
    Location Call Number Limitation Availability
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