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  • S. Karger AG  (8)
  • Medicine  (8)
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  • S. Karger AG  (8)
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  • Medicine  (8)
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  • 1
    Online Resource
    Online Resource
    S. Karger AG ; 1989
    In:  Intervirology Vol. 30, No. 4 ( 1989), p. 234-236
    In: Intervirology, S. Karger AG, Vol. 30, No. 4 ( 1989), p. 234-236
    Type of Medium: Online Resource
    ISSN: 0300-5526 , 1423-0100
    RVK:
    Language: English
    Publisher: S. Karger AG
    Publication Date: 1989
    detail.hit.zdb_id: 1482863-7
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    S. Karger AG ; 2016
    In:  European Neurology Vol. 75, No. 3-4 ( 2016), p. 142-148
    In: European Neurology, S. Karger AG, Vol. 75, No. 3-4 ( 2016), p. 142-148
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 The associations and clinical relevance of serum lipid profiles in patients with acute transverse myelitis (ATM) are unknown. Our study aimed at investigating the status of serum lipid variables (including total cholesterol (TC), triglycerides (TGs), high/low density lipoproteins (HDL/LDL), apolipoprotein A-I (ApoA-I), apolipoprotein B (ApoB) and cholesterol to HDL ratio) in ATM, and to explore whether there was a correlation between serum lipid levels and disease characteristics of ATM. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 We retrospectively evaluated serum lipid levels of 92 patients with ATM, 43 with multiple sclerosis (MS) on relapse and 112 healthy controls (HC). The changes of serum lipid profiles were analyzed. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 We found that ATM patients had higher serum TC, TG, LDL levels and T/H ratio than HC, but had lower levels of serum ApoA-I and ApoB. Besides, there were no significant differences between ATM and MS on relapse (except ApoB). Third, longer disease duration was associated with higher TG; higher HDL was associated with a trend for lower Expanded Disability Status Scale scores. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Our findings showed that serum lipid levels were elevated in patients with ATM, among serum TG and HDL might be associated with clinical features. These results illustrate that a long-term follow-up and regular monitoring of serum lipid profiles are important for ATM patients.
    Type of Medium: Online Resource
    ISSN: 0014-3022 , 1421-9913
    RVK:
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2016
    detail.hit.zdb_id: 1482237-4
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  • 3
    In: Cardiology, S. Karger AG, Vol. 126, No. 1 ( 2013), p. 50-58
    Abstract: 〈 b 〉 〈 i 〉 Objectives: 〈 /i 〉 〈 /b 〉 Systemic or local inflammation causes cardiac nerve sprouting and consequent arrhythmia. Metoprolol can prevent sympathetic nerve remodeling after myocardial infarction (MI), but the underlying mechanism is unclear. In this study, we evaluated the role of metoprolol in ameliorating sympathetic sprouting. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Rabbits underwent ligation of the coronary artery for MI. MI rabbits received metoprolol or saline for 7 days. Immunohistochemistry was used to measure cardiac nerve sprouting and sympathetic innervations. Nuclear factor- & #954;B (NF- & #954;B) DNA binding activity was analyzed by electrophoretic mobility shift assay. The protein levels of NF- & #954;B p65, inhibitor & #954;Ba (I & #954;Ba) and nerve growth factor (NGF) were detected by Western blot analysis. The mRNA levels of NGF, interleukin-1ß (IL-1ß) and tumor necrosis factor-a (TNF-a) were examined by quantitative real-time PCR. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 MI rabbits showed nerve sprouting and sympathetic hyperinnervation. In MI rabbits, as compared with saline treatment, metoprolol reduced NF- & #954;B DNA binding activity and NF- & #954;B p65 level, and increased I & #954;Ba level. Moreover, metoprolol downregulated IL-1ß, TNF-a and NGF levels, and reduced the density of sympathetic nerve fibers. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Metoprolol ameliorates sympathetic nerve sprouting in rabbits after MI and is associated in part with inhibiting NF- & #954;B activity.
    Type of Medium: Online Resource
    ISSN: 0008-6312 , 1421-9751
    RVK:
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2013
    detail.hit.zdb_id: 1482041-9
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  • 4
    In: European Neurology, S. Karger AG, Vol. 65, No. 3 ( 2011), p. 150-155
    Abstract: 〈 i 〉 Background: 〈 /i 〉 We hypothesized that the presence of tiny, enhancing foci (‘spot sign’) within acute hematomas is associated with hematoma expansion. 〈 i 〉 Methods: 〈 /i 〉 We retrospectively analyzed the effect of hematoma volume on accuracy of computed tomographic angiography (CTA) in predicting hematoma expansion in 312 patients with acute intracerebral hemorrhage (ICH). The patients were divided into 2 groups according to their initial hematoma volume ( 〈 30 vs. ≧30 ml). CTA was performed at admission and 24 h after initial presentation. 〈 i 〉 Results: 〈 /i 〉 The 〈 30-ml group consisted of 203 patients of whom 42 had hematoma expansion (20.9%). The ≧30-ml group consisted of 109 patients of whom 34 had hematoma expansion (31.19%). In the 〈 30-ml group, the sensitivity and specificity of CTA in predicting hematoma expansion were 71.4 and 93.8%, respectively. In the ≧30-ml group, the sensitivity and specificity of CTA were 85.7 and 91.9%, respectively. For all 312 patients, the area under the curve was 0.86 (p 〈 0.001, 95% CI 0.80–0.92); the sensitivity and specificity of CTA were 77.9 and 93.2%, respectively. 〈 i 〉 Conclusions: 〈 /i 〉 CTA can reliably predict hematoma expansion in clinical practice, especially for hematomas 〉 30 ml.
    Type of Medium: Online Resource
    ISSN: 0014-3022 , 1421-9913
    RVK:
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2011
    detail.hit.zdb_id: 1482237-4
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  • 5
    In: Cardiology, S. Karger AG, Vol. 127, No. 3 ( 2014), p. 155-163
    Abstract: 〈 b 〉 〈 i 〉 Objectives: 〈 /i 〉 〈 /b 〉 Diabetic cardiac autonomic neuropathy can lead to an increased incidence of ventricular arrhythmias (VAs). However, few data are available regarding the pathogenesis and therapy of the VAs accompanying diabetic cardiac autonomic neuropathy. We aimed to explore whether or not exogenous nerve growth factor (NGF) can reduce the sympathetic heterogeneity and the incidence of VAs in diabetes mellitus (DM). 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Male Wistar rats were randomly divided into 3 groups: controls, rats with DM with saline infused into the left stellate ganglion (LSG), i.e. the DS group and rats with DM with NGF infused into the LSG, i.e. the DN group. After 28 weeks, all rats were subjected to electrophysiological experiments. Sympathetic innervations and NGF were studied by immunostaining, RT-PCR or Western blot analysis. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The incidence of inducible VAs was significantly higher in the DS group than in the control group, but was markedly decreased in the DN group. In the DS group, the tyrosine hydroxylase (TH) and NGF expression were significantly lower than in the other groups, and significant proximal-distal heterogeneities existed regarding the TH and NGF expression in the left ventricle, but were markedly repaired in the DN group. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 NGF intervention in the LSG can reduce the heterogeneity of cardiac sympathetic innervations and the incidence of VAs in diabetic rats.
    Type of Medium: Online Resource
    ISSN: 0008-6312 , 1421-9751
    RVK:
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2014
    detail.hit.zdb_id: 1482041-9
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  • 6
    Online Resource
    Online Resource
    S. Karger AG ; 2008
    In:  Urologia Internationalis Vol. 80, No. 3 ( 2008), p. 321-324
    In: Urologia Internationalis, S. Karger AG, Vol. 80, No. 3 ( 2008), p. 321-324
    Abstract: 〈 i 〉 Objectives: 〈 /i 〉 To assess the role of color Doppler flow imaging (CDFI) in the evaluation of Chinese patients with erectile dysfunction (ED) and to explore the association between penile rigidity and hemodynamic parameters of CDFI. 〈 i 〉 Methods: 〈 /i 〉 Totally 74 ED patients with an age range of 22–69 (median age 47) were included in our study, hemodynamic parameters including the peak systolic velocity (PSV), end-diastolic velocity (EDV) and resistance index (RI) of the penile cavernous artery were measured by CDFI before and after intracavernous pharmacological testing. The degree of penile rigidity was classified according to Schramek grading system. The correlation between the penile rigidity state and its hemodynamic parameters was analyzed. 〈 i 〉 Results: 〈 /i 〉 In ED patients, the abnormalities of cavernous artery and dorsal vein could be evaluated by the value of PSV and EDV with combination of penile rigidity. Among different penile rigidity status, the PSV, EDV and RI of the cavernous artery were significantly different (p 〈 0.05). The RI correlated significantly with the penile rigidity (r 〈 sup 〉 2 〈 /sup 〉 = 0.7948). 〈 i 〉 Conclusion: 〈 /i 〉 The CDFI hemodynamics of the penile cavernous artery are helpful in the etiological diagnosis of Chinese ED patients and can be used as one of the quantitative indexes for penile rigidity, which is consistent with western guidelines.
    Type of Medium: Online Resource
    ISSN: 0042-1138 , 1423-0399
    RVK:
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2008
    detail.hit.zdb_id: 1464417-4
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  • 7
    In: Cardiology, S. Karger AG, Vol. 121, No. 1 ( 2012), p. 1-9
    Abstract: 〈 i 〉 Background: 〈 /i 〉 Abnormal sympathetic innervation underlies both long-term hyperglycemia and myocardial infarction (MI). The incidence of ventricular arrhythmias (VAs) after MI is higher in diabetic than in nondiabetic patients. However, the exact mechanism remains unclear. In this study, we aimed to explore sympathetic neural remodeling after MI in diabetic rabbits and its relationship with VAs. 〈 i 〉 Methods: 〈 /i 〉 Rabbits were randomly assigned to 4 groups: control, diabetes mellitus (DM), MI and diabetic myocardial infarction (DI). After electrophysiological experiments in vivo, immunohistochemistry and real-time RT-PCR were used to measure sympathetic innervations. To test the function of sympathetic nerve fibers, norepinephrine levels were measured by high-performance liquid chromatography. 〈 i 〉 Results: 〈 /i 〉 The corrected QT interval and QT dispersion were significantly more prolonged with DI than other conditions. The density of tyrosine hydroxylase-positive fibers and corresponding mRNA abundance was significantly higher with DI than with DM and under control conditions, but was lower than with the MI group. Moreover, the distribution and structure of regenerated nerve was heterogeneous in DI rabbits. Norepinephrine content was higher in the DI group, and accompanied by an increased quantity of tyrosine hydroxylase-positive fibers. 〈 i 〉 Conclusion: 〈 /i 〉 MI results in sympathetic neural remodeling in diabetic rabbits, which may be responsible in part for the increased occurrence of VAs.
    Type of Medium: Online Resource
    ISSN: 0008-6312 , 1421-9751
    RVK:
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2012
    detail.hit.zdb_id: 1482041-9
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  • 8
    In: Urologia Internationalis, S. Karger AG, Vol. 101, No. 3 ( 2018), p. 320-326
    Abstract: 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 This study aims to observe the morphological characteristics of bacterial biofilm on the surface of ureteral stents and analyze distribution characteristics of pathogens on the bacterial biofilm and drug resistance. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Ureteral stents were sampled from 129 patients. A scanning electron microscope was used to observe the morphological characteristics of bacterial biofilms, and the Congo red medium was applied to screen bacterial biofilm strains on the renal pelvis section, ureter section, and bladder section respectively. Urine culture was performed, and the drug sensitive test analysis was carried out for the pathogenic bacteria detected. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Bacterial biofilms can be observed on the surface of ureteral stents, and these bacteria are embraced by large amounts of fiber membranes. A total of 107 patients were found to be positive for biofilms with a positive rate of 82.9%. The positive rates of the bladder section, ureter section, renal pelvis section, and urine culture were 85.0, 42.9, 67.3, and 24.3% respectively. Pathogenic bacteria mainly concentrated on 〈 i 〉 Escherichia coli 〈 /i 〉 , and the drug resistance rate of the bacterial biofilm strains on the ureteral stent was relatively higher. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 The bacterial biofilm on the ureteral stent is an important factor that induces catheter-associated urinary tract infections.
    Type of Medium: Online Resource
    ISSN: 0042-1138 , 1423-0399
    RVK:
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2018
    detail.hit.zdb_id: 1464417-4
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