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  • 1
    Online Resource
    Online Resource
    Proteomic Analysis Reveals Allergen Variability among Breeds of the Dust Mite 〈b〉〈i〉Blomia tropicalis〈/i〉〈/b〉
    S. Karger AG ; 2019
    In:  International Archives of Allergy and Immunology Vol. 180, No. 3 ( 2019), p. 159-172
    Details
    In: International Archives of Allergy and Immunology, S. Karger AG, Vol. 180, No. 3 ( 2019), p. 159-172
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 The dawn of the “omics” technologies has changed allergy research, increasing the knowledge and identification of new allergens. However, these studies have been almost restricted to 〈 i 〉 Dermatophagoides 〈 /i 〉 spp. Although 〈 i 〉 Blomia tropicalis 〈 /i 〉 has long been established as a clinically important source of allergens, a thorough proteomic characterization is still lacking for this dust mite. 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 To increase knowledge of 〈 i 〉 B. tropicalis 〈 /i 〉 allergens through proteomic analysis. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Eleven in-bred lineages of 〈 i 〉 B. tropicalis 〈 /i 〉 were obtained from 11 unique different pregnant females. Their somatic extracts were analyzed and compared with a commercially available extract by liquid chromatography tandem mass spectrometry (LC-MS/MS). 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Considerable differences in the protein expression profiles were found among the breeds, and most of them displayed higher expression levels of major allergens than the commercially available extract. Blo t 2 was the most prominent allergenic protein in the analyzed extracts. Six identified allergens and 14 isoforms have not yet been recognized by IUIS. Conversely, 3 previously recognized 〈 i 〉 B. tropicalis 〈 /i 〉 allergens were not found. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 The clear impact of inbreeding on allergen content shown by our study leads us to conclude that the quantification and/or identification of allergens from in-bred lines should be routinely considered for mite cultivation in order to select breeds with higher amounts of major allergens. In this sense, LC-MS/MS may be a useful method to achieve this quality control for research and commercial purposes.
    Type of Medium: Online Resource
    ISSN: 1018-2438 , 1423-0097
    URL: Article
    DOI: 10.1159/000501964
    RVK:
    XA 49650
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2019
    detail.hit.zdb_id: 1482722-0
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  • 2
    Online Resource
    Online Resource
    Allergens of 〈b〉〈i〉Blomia tropicalis〈/i〉〈/b〉: An Overview of Recombinant Molecules
    S. Karger AG ; 2017
    In:  International Archives of Allergy and Immunology Vol. 172, No. 4 ( 2017), p. 203-214
    Details
    In: International Archives of Allergy and Immunology, S. Karger AG, Vol. 172, No. 4 ( 2017), p. 203-214
    Abstract: Allergic diseases are considered a major problem for healthcare systems in both developed and developing countries. House dust mites are well-known triggers of allergic manifestations. While the 〈 i 〉 Dermatophagoides 〈 /i 〉 genus is widely distributed globally, 〈 i 〉 Blomia tropicalis 〈 /i 〉 is the most prominent mite species in the tropical and subtropical regions of the world. Over the last decades, an increase in sensitization rates to 〈 i 〉 B. tropicalis 〈 /i 〉 has been reported, leading to increased research efforts on 〈 i 〉 Blomia 〈 /i 〉 allergens. In fact, 8 new allergens have been identified and characterized to different degrees. Here, we provide an overview of recent developments concerning the identification and production of recombinant 〈 i 〉 Blomia 〈 /i 〉 allergens, as well as their structural and immunological characterization. Although considerable progress has been achieved, detailed molecule-based studies are still needed to better define the clinical relevance of 〈 i 〉 Blomia 〈 /i 〉 allergens. Thus, the establishment of a well-standardized and fully characterized panel of allergens remains a challenge for the development of better diagnosis and therapy of allergic diseases induced by 〈 i 〉 B. tropicalis 〈 /i 〉 .
    Type of Medium: Online Resource
    ISSN: 1018-2438 , 1423-0097
    URL: Article
    DOI: 10.1159/000464325
    RVK:
    XA 49650
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2017
    detail.hit.zdb_id: 1482722-0
    Location Call Number Limitation Availability
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    Online Resource
  • 3
    Online Resource
    Online Resource
    What Can Twitter Tell Us about Skin Cancer Communication and Prevention on Social Media?
    S. Karger AG ; 2020
    In:  Dermatology Vol. 236, No. 2 ( 2020), p. 81-89
    Details
    In: Dermatology, S. Karger AG, Vol. 236, No. 2 ( 2020), p. 81-89
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Skin cancer places a substantial burden on the health system in Australia. The modernisation of skin cancer prevention interventions by using social media may enhance their contemporary reach and relevance, especially among the youth. This study aimed to analyse Twitter posts in Australia to establish a baseline of skin cancer and sun-related communication trends. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Tweets posted over the summer of 2018/2019 relating to relevant keywords and hashtags such as “slipslopslap” and “sunscreen” were analysed using quantitative and qualitative methods. The number of tweets, related communication patterns, and possible factors for sudden changes in tweet volume were studied. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Results showed that Australians are using Twitter to communicate about their sun-related and skin cancer experiences and to share advice and information on this matter. Overall, Australians use Twitter more frequently to talk about sunscreen (number of tweets between December 2018 and February 2019 = 5,842) and/or skin cancer ( 〈 i 〉 n 〈 /i 〉 = 3,936), but not so often to communicate about other sun-protective behaviours ( 〈 i 〉 n 〈 /i 〉 = 1,972) or skin cancer prevention campaigns ( 〈 i 〉 n 〈 /i 〉 = 108). The number of tweets is greatly affected by the increase in temperature. Celebrities, non-health-related organisations with a high number of followers, and individuals sharing their own skin cancer experiences achieve a substantial number of likes and retweets and thus influence on Twitter regarding skin cancer-related communication. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 The results allow deeper understanding of important determinants for effective social media use for health promotion and public health messaging in the future. Linking tweets with temperature, sharing by celebrities or non-health-related organisations and individuals with a high following can all contribute to greater spread of skin cancer and sun-related messages.
    Type of Medium: Online Resource
    ISSN: 1018-8665 , 1421-9832
    URL: Article
    DOI: 10.1159/000506458
    RVK:
    XA 37700
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2020
    detail.hit.zdb_id: 1482189-8
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