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  • S. Karger AG  (6)
  • Medicine  (6)
  • 1
    Online Resource
    Online Resource
    Clevudine Demonstrates Potent Antiviral Activity in Naïve Chronic Hepatitis B Patients
    S. Karger AG ; 2010
    In:  Intervirology Vol. 53, No. 2 ( 2010), p. 83-86
    Details
    In: Intervirology, S. Karger AG, Vol. 53, No. 2 ( 2010), p. 83-86
    Abstract: 〈 i 〉 Objectives: 〈 /i 〉 Clevudine has demonstrated antiviral potency in the treatment of naïve chronic hepatitis B patients in pivotal studies. The objectives of this study were to evaluate the safety and efficacy of a 1-year treatment with clevudine in chronic hepatitis B patients. 〈 i 〉 Methods: 〈 /i 〉 This is a post-marketing surveillance using case report forms which were submitted to the health authorities. 〈 i 〉 Results: 〈 /i 〉 Analysis of individual data showed that hepatitis B virus (HBV) DNA after a 1-year treatment was 〈 141,500 copies/ml in 96% of hepatitis B e antigen (HBeAg)-positive and 100% of HBeAg-negative patients. The proportion of patients with HBV DNA 〈 2,000 copies/ml after a 1-year treatment was 74%: 71% of HBeAg-positive and 93% of HBeAg-negative patients. Most of the patients with HBV DNA below the detection limit with each assay at week 24 showed sustained viral suppression up to week 48. The proportion of patients who showed normal alanine aminotransferase at week 48 was 86% in HBeAg-positive patients and 87% in HBeAg-negative patients. The rates of HBeAg-loss were 21%. Two patients showed viral breakthrough during treatment. 〈 i 〉 Conclusion: 〈 /i 〉 Clevudine monotherapy demonstrates potent antiviral activity as well as biochemical and serological response with a 0.7% rate of viral breakthrough in naïve chronic hepatitis B patients.
    Type of Medium: Online Resource
    ISSN: 0300-5526 , 1423-0100
    URL: Article
    DOI: 10.1159/000264197
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2010
    detail.hit.zdb_id: 1482863-7
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    Effects of Uric Acid Levels on Outcome in Severe Ischemic Stroke Patients Treated with Intravenous Recombinant Tissue Plasminogen Activator
    S. Karger AG ; 2014
    In:  European Neurology Vol. 71, No. 3-4 ( 2014), p. 132-139
    Details
    In: European Neurology, S. Karger AG, Vol. 71, No. 3-4 ( 2014), p. 132-139
    Abstract: Uric acid (UA) has been known to be a neuroprotective antioxidant because of its free radical scavenger activity. We studied the influence of UA in patients with acute ischemic stroke after thrombolytic therapy. Two hundred eighteen consecutive patients treated with intravenous thrombolysis were included in this analysis. We analyzed the relationship between serum UA levels obtained at the emergency department and clinical outcomes. Early improvement and excellent functional outcomes were measured using the National Institutes of Health Stroke Scale (NIHSS) 24 h after onset and the modified Rankin scale after 3 months. There was no significant relationship between serum UA levels and early improvement or excellent functional outcome in the total patients (p = 0.583 and p = 0.082, respectively). However, in patients with severe baseline stroke deficits (NIHSS score ≥15), higher-tertile UA levels were significantly associated with excellent functional outcomes (p = 0.003). Excellent functional outcomes in patients with severe baseline disability might have a significant association with serum UA levels particularly in men but not in women (p = 0.007 in men and p = 0.621 in women). Increased serum UA levels might be associated with better outcomes in ischemic stroke patients treated with intravenous thrombolysis, but the effectiveness of UA can differ by initial stroke severity and gender.
    Type of Medium: Online Resource
    ISSN: 0014-3022 , 1421-9913
    URL: Article
    DOI: 10.1159/000355020
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2014
    detail.hit.zdb_id: 1482237-4
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  • 3
    Online Resource
    Online Resource
    Formin-Like 2 Is a Potential Biomarker of Poor Prognosis in Nasopharyngeal Carcinoma
    S. Karger AG ; 2022
    In:  Oncology Vol. 100, No. 9 ( 2022), p. 475-484
    Details
    In: Oncology, S. Karger AG, Vol. 100, No. 9 ( 2022), p. 475-484
    Abstract: 〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 Nasopharyngeal carcinoma (NPC) is the most common malignant tumor in southern China and Southeast Asia. Although substantial research on NPC has been conducted, the resulting improvement in clinical outcomes remains very disappointing. NPC treatment typically involves radiation therapy and chemotherapy, but the high incidence of metastasis and recurrence in NPC patients result in poor survival. Therefore, identifying potential biomarkers and discovering therapeutic targets are necessary to design tailored treatments based on the genetic profiles of NPC patients. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Correlations of protein immunostaining with clinicopathological features were analyzed by Pearson’s χ 〈 sup 〉 2 〈 /sup 〉 test. The Kaplan-Meier method with a log-rank test was used to generate survival curves. Multivariate analysis was performed using the Cox proportional hazards model. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 In this study, we comparatively analyzed cytoskeletal organization and biogenesis (GO:0007010) and tumorigenesis in the NPC transcriptome (GSE12452) and found that formin-like 2 ( 〈 i 〉 FMNL2 〈 /i 〉 ) expression was significantly upregulated in NPC tumor tissues. Moreover, high FMNL2 expression was significantly correlated with primary tumor stage ( 〈 i 〉 p 〈 /i 〉 = 0.001), lymph node status ( 〈 i 〉 p 〈 /i 〉 = 0.004), cancer stage ( 〈 i 〉 p 〈 /i 〉 = 0.006), and histological grade ( 〈 i 〉 p 〈 /i 〉 = 0.040). More importantly, high FMNL2 expression was significantly correlated with poor survival in NPC patients according to univariate analysis and multivariate analysis. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 This study reveals that FMNL2 may be an important potential biomarker for evaluating the prognosis of NPC patients.
    Type of Medium: Online Resource
    ISSN: 0030-2414 , 1423-0232
    URL: Article
    DOI: 10.1159/000525682
    RVK:
    XH 3305
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2022
    detail.hit.zdb_id: 1483096-6
    detail.hit.zdb_id: 250101-6
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  • 4
    Online Resource
    Online Resource
    Disturbed Small Intestinal Motility in the Late Rat Pregnancy
    S. Karger AG ; 1998
    In:  Gynecologic and Obstetric Investigation Vol. 45, No. 4 ( 1998), p. 221-224
    Details
    In: Gynecologic and Obstetric Investigation, S. Karger AG, Vol. 45, No. 4 ( 1998), p. 221-224
    Abstract: We investigated whether various periods of pregnancy might disturb rat gastrointestinal motility. When the proestrus of female rats occurred, they were housed with male rats. Motility studies were conducted on day 7 (first period), day 14 (second) and day 21 (third) of pregnancy, respectively. After the orogastric feeding of radiochromium marker, rats were sacrificed 15 min later. Gastric emptyings of pregnant rats measured at various periods did not differ from the nonpregnant diestrus controls. The geometric center represented intestinal transits in the first, second and third periods of pregnancy and controls were (mean ±SEM) 4.54 ± 0.25, 4.47 ± 0.17, 3.61 ± 0.27 and 4.98 ± 0.13, respectively (p 〈 0.01) while their plasma progesterone levels were 15.6 ± 2.6, 18 ± 1.4, 7.1 ± 0.5 and 8.6 ± 0.4 ng/ml, respectively (p 〈 0.01). This shows that late pregnancy inhibits small intestinal transit, whereas gastric emptying remains unchanged. Altered progesterone during pregnancy is not a main mediator to disturb intestinal transit.
    Type of Medium: Online Resource
    ISSN: 0378-7346 , 1423-002X
    URL: Article
    DOI: 10.1159/000009971
    RVK:
    XA 45603
    Language: English
    Publisher: S. Karger AG
    Publication Date: 1998
    detail.hit.zdb_id: 1482695-1
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  • 5
    Online Resource
    Online Resource
    An Open-Label Safety Study of First-Line Bevacizumab in Combination with Standard Chemotherapy in Chinese Patients with Metastatic Colorectal Cancer Treated in an Expanded Access Program in Taiwan
    S. Karger AG ; 2013
    In:  Oncology Vol. 84, No. 5 ( 2013), p. 299-304
    Details
    In: Oncology, S. Karger AG, Vol. 84, No. 5 ( 2013), p. 299-304
    Abstract: 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 An increased risk of serious adverse effects related to bevacizumab has been observed in many Western studies for metastatic colorectal cancer. To evaluate the safety of bevacizumab in Chinese patients, a safety study was conducted in Taiwan. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Bevacizumab was provided by the Expanded Access Program in combination with first-line chemotherapy per investigator's choice. The primary objective is the safety profile, particularly the targeted adverse events such as proteinuria, bowel perforation, hypertension, wound healing complication, thromboembolism and bleeding. The second objectives include time to disease progression and overall survival time. Patients with major surgical procedure performed within the 28 days of bevacizumab were excluded from this study. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Forty patients were eligible for intent-to-treat analysis. The overall rate of objective response and disease control was 55.2 and 81.6%. The median time to disease progression and overall survival were 11.9 and 22.9 months. The actuarial 2-year survival was 46.6%. Regarding toxicity, 7 subjects (17.5%) had serious adverse effects related to study treatment. None of the patients in this cohort had arterial thrombotic events and bowel perforation. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Bevacizumab demonstrates a similar activity and safety profile in Chinese patients. Life-threatening bowel complications were avoided in this study by excluding patients with major surgery within the first 28 days.
    Type of Medium: Online Resource
    ISSN: 0030-2414 , 1423-0232
    URL: Article
    DOI: 10.1159/000347228
    RVK:
    XH 3305
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2013
    detail.hit.zdb_id: 1483096-6
    detail.hit.zdb_id: 250101-6
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  • 6
    Online Resource
    Online Resource
    Gene Expression Profiling in Melasma in Korean Women
    S. Karger AG ; 2014
    In:  Dermatology Vol. 229, No. 4 ( 2014), p. 333-342
    Details
    In: Dermatology, S. Karger AG, Vol. 229, No. 4 ( 2014), p. 333-342
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 There has been a paucity of data about the difference in gene expression between melasma lesional skin and normal adjacent one. 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 Our aim was to identify novel genes involved in the pathogenesis of melasma. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 We performed a microarray analysis and confirmed the results on quantitative real-time polymerase chain reaction (qRT-PCR) in Korean women with melasma. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 There were 334 genes whose degree of expression showed a significant difference between melasma lesional skin and normal adjacent one. Of these, five were confirmed on qRT-PCR. In melasma lesional skin, there were down-regulation of genes involved in the PPAR signaling pathway and up-regulation of genes involved in neuronal component and the functions of stratum corneum barrier. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 This result suggests that the pathogenesis of melasma might be associated with novel genes involved in the above signaling pathway in Korean women.
    Type of Medium: Online Resource
    ISSN: 1018-8665 , 1421-9832
    URL: Article
    DOI: 10.1159/000365080
    RVK:
    XA 37700
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2014
    detail.hit.zdb_id: 1482189-8
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