In:
European Neurology, S. Karger AG, Vol. 62, No. 2 ( 2009), p. 120-123
Abstract:
Parkinson’s disease (PD) is a neurodegenerative disorder causing muscular rigidity, resting tremor and bradykinesia. We conducted an association study assessing how PD risk in Italy was influenced by the serotonin transporter gene 〈 i 〉 (SLC6A4) 〈 /i 〉 polymorphic region 〈 i 〉 5-HTTLPR 〈 /i 〉 , consisting of an insertion/deletion (long allele-L/short allele-S) of 43 bp in the 〈 i 〉 SLC6A4 〈 /i 〉 promoter region. The 〈 i 〉 SLC6A4 〈 /i 〉 promoter single nucleotide polymorphism 〈 i 〉 rs25531 〈 /i 〉 (A→G) was evaluated too. We collected 837 independent subjects (393 PD, 444 controls). An association between the 〈 i 〉 5-HTTLPR 〈 /i 〉 polymorphism and risk of PD (S/S genotype OR [95% CI]: 1.7[1.2–2.5] , p = 0.002) was found. The 〈 i 〉 rs25531 〈 /i 〉 and the haplotype 〈 i 〉 5-HTTLPR/rs25531 〈 /i 〉 did not associate with risk of PD. Our data indicate that the 〈 i 〉 5-HTTLPR 〈 /i 〉 polymorphic element within the 〈 i 〉 SLC6A4 〈 /i 〉 promoter may govern the genetic risk of PD in Italians.
Type of Medium:
Online Resource
ISSN:
0014-3022
,
1421-9913
Language:
English
Publisher:
S. Karger AG
Publication Date:
2009
detail.hit.zdb_id:
1482237-4
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