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  • S. Karger AG  (10)
  • Medicine  (10)
  • 1
    Online Resource
    Online Resource
    Analysis of Growth Factors and Inflammatory Cytokines in Exhaled Breath Condensate from Asthmatic Children
    S. Karger AG ; 2005
    In:  International Archives of Allergy and Immunology Vol. 137, No. 1 ( 2005), p. 66-72
    Details
    In: International Archives of Allergy and Immunology, S. Karger AG, Vol. 137, No. 1 ( 2005), p. 66-72
    Abstract: 〈 i 〉 Background: 〈 /i 〉 Vascular endothelial growth factor (VEGF), AA isoform of platelet-derived growth factor (PDGF-AA), and epidermal growth factor (EGF) are involved in the pathogenesis of airway inflammation in asthma. These molecules are closely associated with cytokines such as tumor necrosis factor-α (TNF-α) and interleukin (IL)-4. This study investigates the relation between childhood asthma and levels of these mediators in exhaled breath condensate (EBC). 〈 i 〉 Methods: 〈 /i 〉 EBC was collected from asthmatic children and controls using a disposable collection kit, and the concentrations of VEGF, PDGF-AA, EGF, TNF-α and IL-4 in EBC were measured using sandwich enzyme immunoassays. Exhaled nitric oxide concentration was measured by a chemiluminescence analyzer. 〈 i 〉 Results: 〈 /i 〉 Thirty-five asthmatic patients aged between 7 and 18 years and 11 controls were recruited. Sixteen patients had intermittent asthma (IA) whereas 19 of them suffered from persistent asthma (PA). A significant correlation was found between IL-4 and TNF-α in EBC (ρ = 0.374, p = 0.010). PDGF-AA levels in EBC were higher in subjects with diminished FEV 〈 sub 〉 1 〈 /sub 〉 (p = 0.023) whereas IL-4 concentrations were increased in asthmatics (p = 0.007) as well as subjects with increased plasma total IgE (p = 0.033). Patients with PA receiving high-dose inhaled corticosteroid (ICS) had higher EBC IL-4 concentration than those on low-dose ICS (p = 0.007). Linear regression revealed that PDGF-AA levels in EBC were negatively associated with FEV 〈 sub 〉 1 〈 /sub 〉 percentage (β = –0.459, p = 0.006) among the asthmatic patients. 〈 i 〉 Conclusions: 〈 /i 〉 IL-4 in EBC is increased in childhood asthma, and growth factors are detectable in a significant proportion of these children. Increased PDGF-AA is found in asthmatics with more severe airflow limitation.
    Type of Medium: Online Resource
    ISSN: 1018-2438 , 1423-0097
    URL: Article
    DOI: 10.1159/000085106
    RVK:
    XA 49650
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2005
    detail.hit.zdb_id: 1482722-0
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  • 2
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    Preimplantational Genetic Diagnosis and Mutation Detection in a Family with Duplication Mutation of DMD Gene
    S. Karger AG ; 2014
    In:  Gynecologic and Obstetric Investigation Vol. 78, No. 4 ( 2014), p. 272-278
    Details
    In: Gynecologic and Obstetric Investigation, S. Karger AG, Vol. 78, No. 4 ( 2014), p. 272-278
    Abstract: Duchenne muscular dystrophy (DMD) is an X-linked recessive neuromuscular disease caused by mutation in the DMD gene. A 38-year-old woman was referred to our hospital with her son who was diagnosed with DMD. Multiplex PCR failed to detect DMD mutations in the affected child. The female carrier underwent preimplantation genetic diagnosis by linkage analysis and gender determination. Eight embryos were biopsied after in vitro fertilization. Two healthy embryos determined both as females (E1 and E3) were transferred. Although the paternal allele was absent in E3, it was considered to be a result of allele dropout for the STR-49 marker. Surprisingly, a female and a male baby were delivered at 38 gestational weeks, suggesting that E3 was a male embryo with the allele dropout occurring at the SRY gene. Exon 2 duplication was detected in the DMD patient and the carrier mother using next-generation sequencing and multiple ligation-dependent probe amplification. Next, we verified the duplication of exon 2 by real-time PCR, using a special primer at 3′ of intron 1, very close to exon 2. Finally, we confirmed that both newborns inherited the normal allele, using quantitative real-time PCR and linkage analysis.
    Type of Medium: Online Resource
    ISSN: 0378-7346 , 1423-002X
    URL: Article
    DOI: 10.1159/000365083
    RVK:
    XA 45603
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2014
    detail.hit.zdb_id: 1482695-1
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  • 3
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    Online Resource
    The Outcomes of Minimally Invasive Percutaneous Nephrolithotomy with Different Access Sizes for the Single Renal Stone ≤25 mm: A Randomized Prospective Study
    S. Karger AG ; 2022
    In:  Urologia Internationalis Vol. 106, No. 5 ( 2022), p. 440-445
    Details
    In: Urologia Internationalis, S. Karger AG, Vol. 106, No. 5 ( 2022), p. 440-445
    Abstract: 〈 b 〉 〈 i 〉 Objectives: 〈 /i 〉 〈 /b 〉 The aim of this study was to provide a randomized controlled trial comparing the outcomes of different access sizes used in the solo ultrasonic-guided minimally invasive percutaneous nephrolithotomy (mini-PCNL). 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 From January 2018 to December 2019, a total of 160 cases with single renal stones of & #x3c;25 mm were randomized to undergo mini-PCNLs with Fr16, Fr18, Fr20, or Fr22 accesses. All accesses were established with the axis of the target calyx as the marker for puncture location and then expanded to the desired size. Hemoglobin reduction, operative time, stone-free rate, complications, etc., were all recorded and assessed. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The demographic data were similar, and there were no significantly intergroup differences in stone-free rate, complications, and hospital stay time. The hemoglobin reduction was comparable and was 0.9 ± 0.6, 0.9 ± 0.7, 1.0 ± 0.5, and 1.1 ± 0.7 g/dL for the groups Fr16, Fr18, Fr20, and Fr22, respectively. The operative time was 53.4 ± 14.5, 48.5 ± 15.2, 42.8 ± 13.3, and 43.3 ± 13.1 min for the 4 groups, which decreased significantly from group Fr16 to Fr20, but there was no significant difference between Fr20 and Fr22 groups. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 The axis of target calyx is a reliable marker for establishment of percutaneous renal access under ultrasonic guidance. The surgical outcomes of different access sizes were comparable, but the operation time was significantly shortened with the increase of size. However, Fr22 was not more efficient than Fr20.
    Type of Medium: Online Resource
    ISSN: 0042-1138 , 1423-0399
    URL: Article
    DOI: 10.1159/000516914
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2022
    detail.hit.zdb_id: 1464417-4
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  • 4
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    Online Resource
    Translation and Validation of a Chinese Version of the Parental Self-Efficacy with Eczema Care Index
    S. Karger AG ; 2020
    In:  Dermatology Vol. 236, No. 4 ( 2020), p. 361-368
    Details
    In: Dermatology, S. Karger AG, Vol. 236, No. 4 ( 2020), p. 361-368
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Parental self-efficacy has been found to be a critical determinant of the efficacy of interventions intended to enhance the parental management of childhood eczema. 〈 b 〉 〈 i 〉 Objectives: 〈 /i 〉 〈 /b 〉 The psychometric properties of a translated Chinese version of the Parental Self-Efficacy with Eczema Care Index (C-PASECI) were examined. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 The PASECI was translated in a 2-stage process involving both forward and backward translation. Subsequently, the psychometric properties of the C-PASECI were examined in a cohort of 147 Chinese parents or caregivers of children with eczema. Specifically, the internal consistency, 2-day test-retest reliability and construct validity were assessed. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The C-PASECI received a Cronbach’s αof 0.97, and the intraclass correlation coefficients of each item ranged from 0.93 to 0.99. Negative correlations were observed among the C-PASECI, Children’s Dermatology Life Quality Index and Scoring Atopic Dermatitis Scale scores, indicating the acceptable convergent validity of the C-PASECI. The moderate correlation observed between the C-PASECI and General Self-Efficacy Scale (Pearson’s 〈 i 〉 r 〈 /i 〉 = 0.53, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001) reflected the acceptable concurrent validity of the C-PASECI. The results of confirmatory factor analysis supported the factorial validity of the C-PASECI. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 The C-PASECI appears to be a reliable and valid measure of parental self-efficacy in Chinese parents or caregivers of children with eczema.
    Type of Medium: Online Resource
    ISSN: 1018-8665 , 1421-9832
    URL: Article
    DOI: 10.1159/000505450
    RVK:
    XA 37700
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2020
    detail.hit.zdb_id: 1482189-8
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  • 5
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    Eosinophil Differentiation and Hypodensity Alteration Activities in 〈i〉Dermatophagoides pteronyssinu〈/i〉〈i〉s〈/i〉-Stimulated Mononuclear Cell Culture Supernatants Derived from Asthmatics
    S. Karger AG ; 1995
    In:  International Archives of Allergy and Immunology Vol. 106, No. 3 ( 1995), p. 297-301
    Details
    In: International Archives of Allergy and Immunology, S. Karger AG, Vol. 106, No. 3 ( 1995), p. 297-301
    Type of Medium: Online Resource
    ISSN: 1018-2438 , 1423-0097
    URL: Article
    DOI: 10.1159/000236858
    RVK:
    XA 49650
    Language: English
    Publisher: S. Karger AG
    Publication Date: 1995
    detail.hit.zdb_id: 1482722-0
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  • 6
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    Indoor Determinants of Endotoxin and Dust Mite Exposures in Hong Kong Homes with Asthmatic Children
    S. Karger AG ; 2010
    In:  International Archives of Allergy and Immunology Vol. 152, No. 3 ( 2010), p. 279-287
    Details
    In: International Archives of Allergy and Immunology, S. Karger AG, Vol. 152, No. 3 ( 2010), p. 279-287
    Abstract: 〈 i 〉 Background: 〈 /i 〉 Domestic endotoxin enhances airway inflammation and increases asthma severity in Caucasian children, but little data are published on indoor endotoxin exposure in Asian countries. This study investigated house dust endotoxin and Der p 1 levels in Hong Kong families with asthmatic children, and their effects on asthma severity. 〈 i 〉 Methods: 〈 /i 〉 115 asthmatics from a pediatric clinic underwent fractional exhaled nitric oxide (FeNO) and spirometric measurements. Home visits were then made within 2 weeks, during which parents completed the International Study of Asthma and Allergies in Childhood questionnaire. Settled dust was collected from patients’ mattresses, bedroom floors and living room floors. Endotoxin and Der p 1 were measured by limulus amebocyte lysate and immunoassay, respectively. 〈 i 〉 Results: 〈 /i 〉 Endotoxin was detectable in all locations from all families, whereas Der p 1 was detectable in 58–70% of indoor sites. Floors of both bedroom and living rooms had higher endotoxin but lower Der p 1 levels than mattresses (p 〈 0.001 for both). Mattress endotoxin level correlated inversely with Der p 1 level (r = –0.308, p = 0.001). Household smoker, feather bedding and vacuum cleaning were independent determinants of indoor endotoxin. Timing of last bedding change was associated with Der p 1 levels at all sites. Mattress endotoxin level was associated with frequency of wheezing episodes (p = 0.044), but neither endotoxin nor Der p 1 was associated with FeNO and spirometric parameters. 〈 i 〉 Conclusions: 〈 /i 〉 Domestic endotoxin levels are associated with frequency of wheezing episodes in asthmatic children but not their FeNO or spirometric measurements.
    Type of Medium: Online Resource
    ISSN: 1018-2438 , 1423-0097
    URL: Article
    DOI: 10.1159/000283039
    RVK:
    XA 49650
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2010
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  • 7
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    Construction and Evaluation of a Rat Model of Postpartum Fatigue
    S. Karger AG ; 2021
    In:  Gynecologic and Obstetric Investigation Vol. 86, No. 4 ( 2021), p. 370-378
    Details
    In: Gynecologic and Obstetric Investigation, S. Karger AG, Vol. 86, No. 4 ( 2021), p. 370-378
    Abstract: 〈 b 〉 〈 i 〉 Objectives: 〈 /i 〉 〈 /b 〉 The aim of the study was to construct and evaluate a rat model of postpartum fatigue. 〈 b 〉 〈 i 〉 Design: 〈 /i 〉 〈 /b 〉 This is an article about animal model building. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Sprague-Dawley rats on the 1st day after delivery were randomized into control group and fatigue group. The deep sleep of rats was interfered with by forcing them to stand in water, to make the rats experience mental and physical fatigue. To maintain galactosis and lactation, rats and pups were caged for 90 min after every 3 h of separation. The control group was separated routinely without any stimulus. The model was evaluated from mental and physical fatigue on the 8th day and 15th day. The mental fatigue was evaluated by a water maze test and the rat’s 5-hydroxytryptamine (5-HT) level in hippocampus, while the physical fatigue was evaluated using lactic acid level in serum and duration of weight-loaded forced swimming. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Among the 7-day and 14-day modeling groups, compared with the control group, the success rate of water maze landing was significantly decreased, the time for water maze landing was significantly prolonged and 5-HT level in hippocampus significantly decreased in the fatigue group. With respect to physical fatigue, among the 7-day and 14-day modeling groups, the lactic acid level in serum in the fatigue group was significantly increased, and the duration of exhaustive swimming of rats was significantly shortened. 〈 b 〉 〈 i 〉 Limitations: 〈 /i 〉 〈 /b 〉 A small sample size was the main limitation of this study. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 We have successfully constructed a rat model of postpartum fatigue by forcing postpartum rats to stand in water, which was similar to a level of stress that contributes to the development of postpartum fatigue. Our model opens the door for future studies evaluating the effectiveness of pharmacological and behavioral therapies.
    Type of Medium: Online Resource
    ISSN: 0378-7346 , 1423-002X
    URL: Article
    DOI: 10.1159/000517997
    RVK:
    XA 45603
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2021
    detail.hit.zdb_id: 1482695-1
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  • 8
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    Online Resource
    Association between Obesity and Atopy in Chinese Schoolchildren
    S. Karger AG ; 2009
    In:  International Archives of Allergy and Immunology Vol. 149, No. 2 ( 2009), p. 133-140
    Details
    In: International Archives of Allergy and Immunology, S. Karger AG, Vol. 149, No. 2 ( 2009), p. 133-140
    Abstract: 〈 i 〉 Background: 〈 /i 〉 Despite parallel increases in asthma and obesity prevalence, there is little data on obesity as a risk factor for atopy. The latter is an important phenotype in asthmatic patients. This study investigates the association between asthma traits, atopy and obesity-related markers in Chinese adolescents. 〈 i 〉 Methods: 〈 /i 〉 486 schoolchildren were recruited among participants of our population-based study on the epidemiology of obesity, and their allergy status was ascertained using a standardized questionnaire. Subjects’ anthropometry was recorded on-site, and fasting blood was collected for allergen-specific immunoglobulin E (IgE), lipids and systemic inflammatory biomarkers. 〈 i 〉 Results: 〈 /i 〉 98 (20.2%) subjects were classified as overweight or obese. Obesity status was not associated with asthma, allergic rhinitis or eczema (p 〉 0.25). Atopy was not associated with age-adjusted body mass index (BMI) or waist circumference. Atopy and presence of allergen-specific IgE did not differ between overweight or obese children and those with normal BMI (p 〉 0.25), although subgroup analysis suggested that cockroach sensitization was more common among males who were obese or overweight (p = 0.045). White cell count (WCC) was higher among atopic than nonatopic children (mean values 6.5 × 10 〈 sup 〉 9 〈 /sup 〉 /l vs. 6.2 × 10 〈 sup 〉 9 〈 /sup 〉 /l, p = 0.006). Logistic regression revealed WCC to be the only risk factor for atopy (OR 18.97, p = 0.004). 〈 i 〉 Conclusions: 〈 /i 〉 Obesity is not associated with asthma or atopy in Chinese children. High WCC is an important risk factor for atopy in both males and females. Gender does not exert any consistent effect on the association between obesity and allergen sensitization in children.
    Type of Medium: Online Resource
    ISSN: 1018-2438 , 1423-0097
    URL: Article
    DOI: 10.1159/000189196
    RVK:
    XA 49650
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2009
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  • 9
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    Diagnosis of Vertigo and Dizziness Syndromes in a Neurological Outpatient Clinic
    S. Karger AG ; 2018
    In:  European Neurology Vol. 79, No. 5-6 ( 2018), p. 287-294
    Details
    In: European Neurology, S. Karger AG, Vol. 79, No. 5-6 ( 2018), p. 287-294
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Dizziness and vertigo are frequent complaints of outpatients in the neurological department. Our objective was to explore the epidemiological category and clinical features of patients with dizziness or vertigo in the neurological outpatient department of a tertiary hospital. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 We consecutively recruited all patients with dizziness and/or vertigo visiting the neurological outpatient clinic of the First Affiliated Hospital of Chongqing Medical University from January 2016 to June 2017. All patients were interviewed by 4 neurologists and they completed self-administered questionnaires. General physical and standardized neuro-otology bedside examinations were performed in all participants. Instrumental examinations and other related examinations were prescribed as needed. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 A total of 392 patients, 272 female and 120 male, were enrolled and the ratio of males to females was 1: 2.27. The mean age was 52.39 ± 13.87 years (range 11–90). Elderly patients (≥60 years) accounted for about one-third of the patients. Peripheral vestibular disorders accounted for 54.6% of patients, central vestibular disorders (including vestibular migraine [VM]) accounted for 22.4% of patients, psychogenic vertigo in 64 (16.3%), other reasons in 9 (2.3%) and unknown in 17 (4.3%). Benign paroxysmal positional vertigo (BPPV; 30.8%), psychiatric dizziness (20.5%), and VM (14.4%) were the 3 major vestibular diseases in patients under 60 years of age; however, BPPV (27.9%), central vertigo (21.7%), and Meniere’s disease (11.7%) were more common in patients over 60 years of age. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 This study provided a classification and clinical features of vestibular disorders in a neurological outpatient department of a tertiary hospital in China. The spectrum of vertigo or dizziness is different between different age groups and clinicians should pay attention to this difference in clinical reasoning.
    Type of Medium: Online Resource
    ISSN: 0014-3022 , 1421-9913
    URL: Article
    DOI: 10.1159/000489639
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2018
    detail.hit.zdb_id: 1482237-4
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  • 10
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    Online Resource
    Changes in Retinal Nerve Fiber Layer Thickness in Obstructive Sleep Apnea/Hypopnea Syndrome: A Meta-Analysis
    S. Karger AG ; 2016
    In:  Ophthalmic Research Vol. 56, No. 2 ( 2016), p. 57-67
    Details
    In: Ophthalmic Research, S. Karger AG, Vol. 56, No. 2 ( 2016), p. 57-67
    Abstract: 〈 b 〉 〈 i 〉 Purpose: 〈 /i 〉 〈 /b 〉 To evaluate and compare changes in retinal nerve fiber layer (RNFL) thickness in patients with obstructive sleep apnea/hypopnea syndrome (OSAHS). 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 The Cochrane Library, Medline, and Embase were screened using our key words. Results were carefully reviewed to ensure that the included studies met the inclusion/exclusion criteria, and the quality of the studies was assessed using the Newcastle-Ottawa Scale. All included studies categorized patients with OSAHS into 3 groups (mild, moderate, and severe), and measured average and 4-quadrant (temporal, superior, nasal, and inferior) RNFL thickness. All studies included a healthy control group. The weighted mean differences and 95% confidence intervals were calculated for the continuous outcomes. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Ten case-control studies were included in the meta-analysis, consisting of a total of 811 OSAHS group and 868 healthy eyes. A meta-analysis of the data showed that the average RNFL thicknesses in the mild, moderate, and severe OSAHS groups were significantly decreased compared to healthy controls. Additionally, RNFL thickness was significantly reduced in all but the temporal quadrant in the moderate and severe OSAHS groups when compared to healthy controls. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 On the basis of these results, we suggest that peripapillary RNFL thickness as measured by optical coherence tomography could be a useful tool to monitor and assess the severity of OSAHS in patients. Further studies are required in order to differentiate these RNFL changes from glaucomatous changes. This has not been properly examined in any of the studies we were able to identify.
    Type of Medium: Online Resource
    ISSN: 0030-3747 , 1423-0259
    URL: Article
    DOI: 10.1159/000444301
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2016
    detail.hit.zdb_id: 1483177-6
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