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  • S. Karger AG  (11)
  • Medicine  (11)
  • 1
    Online Resource
    Online Resource
    Increased Levels of Total 〈b〉〈i〉p〈/i〉〈/b〉-Cresylsulfate Are Associated with Pruritus in Patients with Chronic Kidney Disease
    S. Karger AG ; 2016
    In:  Dermatology Vol. 232, No. 3 ( 2016), p. 363-370
    Details
    In: Dermatology, S. Karger AG, Vol. 232, No. 3 ( 2016), p. 363-370
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Pruritus is a common and distressing symptom that affects patients with chronic kidney disease (CKD). Indoxyl sulfate (IS) and 〈 i 〉 p 〈 /i 〉 -cresylsulfate (PCS) are uremic toxins with similar protein binding, dialytic clearance, and proinflammatory features. Pruritus in CKD may correlate better with uremic toxins than the glomerular filtration rate (GFR), suggesting that uremic toxins either in the central nervous system or peripherally may play an important role in the pathophysiology. 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 We sought to investigate the potential contribution of serum total IS and PCS to the pathogenesis of pruritus. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 The serum levels of total IS and PCS concentrations were measured in all patients by using the Ultra Performance LC System. The characteristics of pruritus were assessed using a visual analog scale score and an interview questionnaire. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Among the 320 CKD patients, 35% had pruritus. The patients with pruritus were older and had a higher frequency of diabetes mellitus, higher uric acid, calcium, phosphorus, creatinine, high-sensitivity C-reactive protein, and total IS and PCS levels, and lower albumin concentrations and estimated GFR (eGFR) than those without pruritus. Increasing concentrations of total PCS were independently and significantly associated with pruritus. Multiple logistic regression analysis revealed total PCS as an independent association factor for pruritus, even after full adjustment of known biomarkers. Furthermore, serum total PCS levels were positively associated with calcium, phosphorus, blood urea nitrogen, creatinine, and white blood cell count, and negatively associated with eGFR, hemoglobin, and hematocrit. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Our results indicate that total PCS may play a role in the pathogenesis of pruritus.
    Type of Medium: Online Resource
    ISSN: 1018-8665 , 1421-9832
    URL: Article
    DOI: 10.1159/000445429
    RVK:
    XA 37700
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2016
    detail.hit.zdb_id: 1482189-8
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  • 2
    Online Resource
    Online Resource
    Balance between Plasma Levels of Tumor Necrosis Factor-α and Interleukin-10 in Rheumatic Mitral Stenosis
    S. Karger AG ; 2005
    In:  Cardiology Vol. 104, No. 4 ( 2005), p. 171-175
    Details
    In: Cardiology, S. Karger AG, Vol. 104, No. 4 ( 2005), p. 171-175
    Abstract: The study population consisted of 16 patients with rheumatic mitral stenosis undergoing percutaneous transluminal mitral valvuloplasty (group 1). The plasma levels of tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10) in the femoral vein and the right and left atria before valvuloplasty were determined by ELISA. Additionally, we measured plasma concentrations of TNF-α and IL-10 in the venous blood obtained from 19 control patients, including 12 healthy volunteers in sinus rhythm (group 2) and 7 patients in permanent lone atrial fibrillation (group 3). The venous plasma levels of TNF-α were significantly elevated in group 1 patients compared with group 2 patients (p 〈 0.002). Correlation analysis demonstrated that there was a significantly direct relationship between the plasma TNF-α and IL-10 concentrations in the left atrial, right atrial and peripheral venous blood (p 〈 0.008, r = 0.640; p 〈 0.04, r = 0.538; p 〈 0.03, r = 0.571, respectively). In conclusion, the plasma concentrations of TNF-α of patients with rheumatic mitral stenosis were significantly higher than those of healthy volunteers. In addition, there was a significantly direct relationship between the soluble TNF-α and IL-10 concentrations in the atrial and peripheral venous blood, indicating a balance between circulating TNF-α and IL-10 levels in patients with rheumatic mitral stenosis.
    Type of Medium: Online Resource
    ISSN: 0008-6312 , 1421-9751
    URL: Article
    DOI: 10.1159/000088104
    RVK:
    XA 36200
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2005
    detail.hit.zdb_id: 1482041-9
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  • 3
    Online Resource
    Online Resource
    Effects and Safety of Intracoronary Thrombectomy Using Transradial Application of the PercuSurge Distal Balloon Protection System in Patients with Early or Recent Myocardial Infarction
    S. Karger AG ; 2004
    In:  Cardiology Vol. 102, No. 4 ( 2004), p. 206-214
    Details
    In: Cardiology, S. Karger AG, Vol. 102, No. 4 ( 2004), p. 206-214
    Abstract: 〈 i 〉 Background: 〈 /i 〉 Distal embolization and no reflow are likely during primary percutaneous coronary intervention (PCI) on the large infarct-related artery (IRA), which mostly contains high-burden thrombus formation (HBTF) and plaque burden. Mechanical devices to prevent distal atheroembolism may be of importance for preserving reperfusion and microvascular integrity in IRA. 〈 i 〉 Methods and Results: 〈 /i 〉 Between May 2002 and December 2002, transradial application (TRA) of the PercuSurge GuardWire™ device with 7-french arterial sheath was performed in 39 consecutive patients who experienced early ( 〉 12 h and ≤7 days) or recent ( 〉 7 days and 〈 14 days) myocardial infarction (MI) associated with large IRA (vessel size ≧3.5 mm with HBTF; group 1). Between January 2001 and April 2002, 64 consecutive patients who had early or recent MI associated with HBTF in IRA of a vessel size ≧3.5 mm received TRA of PCI with adjunctive tirofiban therapy but without using the adjunctive PercuSurge GuardWire device (group 2). The angiographic and clinical outcomes of both groups were compared in a chronologically consecutive manner. The procedural success rate and post-PCI myocardial blush grades were significantly higher in group 1 than in group 2 patients (all p values 〈 0.05), whereas a combined incidence of vascular and bleeding complications and 30-day major adverse cardiac events (defined as death, reinfarction and repeated PCI of IRA) were significantly higher in group 2 than in group 1 patients (all p values 〈 0.05). 〈 i 〉 Conclusions: 〈 /i 〉 Our data suggested that TRA using the PercuSurge GuardWire device during PCI for patients with early or recent MI and HBTF in IRA was safe and feasible. This mechanical device provided more additional benefit to patients in this clinical setting than a combination of conventional PCI and tirofiban therapy.
    Type of Medium: Online Resource
    ISSN: 0008-6312 , 1421-9751
    URL: Article
    DOI: 10.1159/000081012
    RVK:
    XA 36200
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2004
    detail.hit.zdb_id: 1482041-9
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  • 4
    Online Resource
    Online Resource
    Lymph Node Metastases in Gastric Cancer: Significance of Positive Number
    S. Karger AG ; 1995
    In:  Oncology Vol. 52, No. 1 ( 1995), p. 45-50
    Details
    In: Oncology, S. Karger AG, Vol. 52, No. 1 ( 1995), p. 45-50
    Type of Medium: Online Resource
    ISSN: 0030-2414 , 1423-0232
    URL: Article
    DOI: 10.1159/000227426
    RVK:
    XH 3305
    Language: English
    Publisher: S. Karger AG
    Publication Date: 1995
    detail.hit.zdb_id: 1483096-6
    detail.hit.zdb_id: 250101-6
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  • 5
    Online Resource
    Online Resource
    Predictors of Clinical Deterioration during Hospitalization following Acute Ischemic Stroke
    S. Karger AG ; 2012
    In:  European Neurology Vol. 67, No. 3 ( 2012), p. 186-192
    Details
    In: European Neurology, S. Karger AG, Vol. 67, No. 3 ( 2012), p. 186-192
    Abstract: 〈 i 〉 Background/Aims: 〈 /i 〉 A number of risk factors for early worsening of neurological symptoms have been identified. We aimed to evaluate the influence of hemorheologic, biochemical, and metabolic factors on neurological deterioration during hospitalization following acute ischemic stroke and develop a model of neurological deterioration. 〈 i 〉 Methods: 〈 /i 〉 Worsening of stroke was defined as a deleterious increase in NIH Stroke Scale (NIHSS) score of ≧4 points during hospitalization. We performed multivariate logistic regression analysis and constructed a prediction model based on chart data of 2,398 patients admitted at five medical centers; 203 of the patients had worsening of stroke and 2,186 had not. 〈 i 〉 Results: 〈 /i 〉 The results of multivariate logistic regression analysis showed that hemoglobin (odds ratio: 0.529) and albumin (odds ratio: 0.024) were significantly associated with stroke deterioration, as were the modified Rankin Scale on emergency department admission (odds ratio: 4.956) and length of hospitalization (odds ratio: 1.201). After adjusting for age, gender and NIHSS on emergency department admission, only hemoglobin (odds ratio: 0.894, 95% confidence interval: 0.814–0.981, p = 0.018) was associated with worsening. 〈 i 〉 Conclusion: 〈 /i 〉 Hemoglobin and albumin were found to be risk factors for persistent neurological deterioration during hospitalization following acute ischemic stroke, suggesting that blood viscosity may be related to neurological deterioration.
    Type of Medium: Online Resource
    ISSN: 0014-3022 , 1421-9913
    URL: Article
    DOI: 10.1159/000334723
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2012
    detail.hit.zdb_id: 1482237-4
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  • 6
    Online Resource
    Online Resource
    Analysis of the Interleukin-6 (-174) Locus Polymorphism and Serum IL-6 Levels with the Severity of Normal Tension Glaucoma
    S. Karger AG ; 2017
    In:  Ophthalmic Research Vol. 57, No. 4 ( 2017), p. 224-229
    Details
    In: Ophthalmic Research, S. Karger AG, Vol. 57, No. 4 ( 2017), p. 224-229
    Abstract: 〈 b 〉 〈 i 〉 Purpose: 〈 /i 〉 〈 /b 〉 In normal tension glaucoma (NTG), factors other than elevated intraocular pressure are likely to have a role in the pathogenesis of optic neuropathy. Recent studies of glaucoma or retinal ganglion cells (RGCs) reveal that the cytokine interleukin-6 (IL-6) is linked to the pathogenesis of glaucoma and may regulate RGC survival or death. The IL-6 (-174) G allele has also been shown to increase the IL-6 protein. We hypothesized that the IL-6 (-174) polymorphism may be a predisposing genetic factor affecting the severity of glaucoma. The aim of the present study was to evaluate the IL-6 polymorphism and serum IL-6 levels as a potential risk factor related to the severity of NTG. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 A total of 256 subjects with NTG in the Chinese population were enrolled. The patients were genotyped for the IL-6 (-174) C/G polymorphism. Genomic DNA was amplified by a polymerase chain reaction, followed by the enzymatic restriction fragment length polymorphism technique. Serum IL-6 levels were measured by ELISA. Patient age at diagnosis, cup/disc (C/D) ratio, rim area (RA), retinal nerve fiber layer (RNFL) thickness, and visual field (VF) were analyzed. The associations between genotypes of IL-6 (-174) C/G and the clinical parameters were calculated using a logistic regression. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The IL-6 (-174) GC genotype in NTG patients was significantly associated with a smaller C/D ratio ( 〈 i 〉 p 〈 /i 〉 = 0.04), larger RA ( 〈 i 〉 p 〈 /i 〉 = 0.04), and thicker RNFL ( 〈 i 〉 p 〈 /i 〉 = 0.05) compared with IL-6 (-174) GG patients. The allele frequency of IL-6 (-174) C was significantly higher in the NTG patients at an early-moderate stage than at an advanced stage according to the C/D ratio (OR 0.55; 95% CI 0.31-0.99). Pattern standard deviation of VF was borderline lower in IL-6 (-174) GC patients ( 〈 i 〉 p 〈 /i 〉 = 0.06), and serum IL-6 levels were borderline higher in advanced stages than in early-moderate stages (7.66 ± 3.22 vs. 4.46 ± 3.83 pg/mL; 〈 i 〉 p 〈 /i 〉 = 0.06). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 The IL-6 (-174) GC genotype is associated with a smaller C/D ratio, larger RA, and thicker RNFL compared with IL-6 (-174) GG in NTG patients. We found that the IL-6 (-174) G/C polymorphism and serum IL-6 levels may be associated with the severity of NTG.
    Type of Medium: Online Resource
    ISSN: 0030-3747 , 1423-0259
    URL: Article
    DOI: 10.1159/000455152
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2017
    detail.hit.zdb_id: 1483177-6
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  • 7
    Online Resource
    Online Resource
    A Case of Ophthalmoplegic Migraine Mimicking Ocular Myasthenia gravis
    S. Karger AG ; 2005
    In:  European Neurology Vol. 53, No. 4 ( 2005), p. 215-217
    Details
    In: European Neurology, S. Karger AG, Vol. 53, No. 4 ( 2005), p. 215-217
    Type of Medium: Online Resource
    ISSN: 0014-3022 , 1421-9913
    URL: Article
    DOI: 10.1159/000086734
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2005
    detail.hit.zdb_id: 1482237-4
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  • 8
    Online Resource
    Online Resource
    Sleep Disturbance and Its Association with Gastrointestinal Symptoms/Diseases and Psychological Comorbidity
    S. Karger AG ; 2019
    In:  Digestion Vol. 99, No. 3 ( 2019), p. 205-212
    Details
    In: Digestion, S. Karger AG, Vol. 99, No. 3 ( 2019), p. 205-212
    Abstract: 〈 b 〉 〈 i 〉 Background/Aims: 〈 /i 〉 〈 /b 〉 We aimed to investigate gastrointestinal symptoms, clinical characteristics, and psychological factors in subjects with and without sleep disturbance (SD) in a health screening cohort. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 We enrolled 2,752 consecutive subjects during their health checkups. All participants underwent an evaluation with questionnaires. Demographic characteristics and biochemical data were recorded. SD was confirmed when Pittsburgh Sleep Quality Index score was greater than 5. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Among the study population ( 〈 i 〉 n 〈 /i 〉 = 2,674), 956 (36%) individuals had SD. SD was associated with female gender, older age, lower level of education, higher systolic blood pressure, higher serum high-density lipoprotein levels and higher prevalence of functional dyspepsia and irritable bowel syndrome (IBS). SD subjects also had more depression, more anxiety, more severe gastrointestinal reflux disease symptoms and higher prevalence of non-erosive reflux disease (NERD; 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001). SD was ­independently associated with female gender (OR 1.75, 〈 i 〉 p  〈 /i 〉 & #x3c; 0.001), older age (OR 1.03, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001), NERD (OR 1.88, 〈 i 〉 p 〈 /i 〉 = 0.004), IBS (OR 1.51, 〈 i 〉 p 〈 /i 〉 = 0.043), and depression (OR 1.16, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001) by multivariate analysis. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Future studies will be needed to clarify the interrelationships among SD, psychological stress, and functional gastrointestinal disorders.
    Type of Medium: Online Resource
    ISSN: 0012-2823 , 1421-9867
    URL: Article
    DOI: 10.1159/000490941
    RVK:
    XA 40650
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2019
    detail.hit.zdb_id: 1482218-0
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  • 9
    Online Resource
    Online Resource
    Plasmapheresis in the Treatment of Ataxic Sensory Neuropathy Associated with Sjögren’s Syndrome
    S. Karger AG ; 2001
    In:  European Neurology Vol. 45, No. 4 ( 2001), p. 270-274
    Details
    In: European Neurology, S. Karger AG, Vol. 45, No. 4 ( 2001), p. 270-274
    Abstract: Sjögren’s syndrome (SS) is an important but poorly recognized cause of peripheral neuropathy. Several forms of peripheral nerve dysfunction occur, including trigeminal sensory neuropathy, mononeuropathy multiplex, distal sensorimotor polyneuropathy and pure sensory neuronopathy. The pathological findings vary and the definite treatment is not known. Here we present 4 cases of acute ataxic sensory polyneuropathy with SS, and the experience of treatment with plasmapheresis (PP). The 4 patients were all females; ages ranged from 30 to 58 years. All had prominent loss of kinesthetic and proprioceptive sensation. The course ranged from acute to subacute onset. Patients were treated with 5–9 sessions of PP. Two patients with initiation of treatment within 2 weeks of onset showed dramatic and sustained responses after PP, while the other 2 had no detectable effects. Our experience showed that PP should be considered in patients who present with sensory neuropathy associated with SS, and the treatment should be given as early as possible.
    Type of Medium: Online Resource
    ISSN: 0014-3022 , 1421-9913
    URL: Article
    DOI: 10.1159/000052142
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2001
    detail.hit.zdb_id: 1482237-4
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  • 10
    Online Resource
    Online Resource
    Association of RS2200733 but Not RS10033464 on 4q25 with Atrial Fibrillation Based on the Recessive Model in a Taiwanese Population
    S. Karger AG ; 2010
    In:  Cardiology Vol. 116, No. 3 ( 2010), p. 151-156
    Details
    In: Cardiology, S. Karger AG, Vol. 116, No. 3 ( 2010), p. 151-156
    Abstract: 〈 i 〉 Objectives: 〈 /i 〉 To determine the association between genetic variants on chromosome 4q25 and atrial fibrillation (AF) in a Taiwanese population. 〈 i 〉 Methods: 〈 /i 〉 We enrolled 200 patients with AF (mean age: 67 ± 13 years) and 158 controls (mean age: 63 ± 10 years). The genotypes of five SNPs, RS2634073, RS2200733, RS13143308, RS2220427 and RS10033464, were determined using multiplex single base extension methods. 〈 i 〉 Results: 〈 /i 〉 The distribution of the RS2200733 and RS10033464 genotypes did not significantly deviate from the Hardy-Weinberg equilibrium in the control group. The distribution of the RS2200733 genotypes differed significantly between the AF group and the controls (p = 0.03), whereas the distribution of the RS10033464 genotypes did not (p = 0.49). At RS2200733, patients with the CC genotype exhibited a 0.45 times higher risk of developing AF than those with the TT genotype (p = 0.02) and a recessive model was suggested (p = 0.01). After adjusting for various covariates, patients with the CC genotype remained recessively associated with a lower risk of developing AF than those with the TT genotype (odds ratio: 0.27, 95% confidence interval: 0.11–0.65; p 〈 0.01). 〈 i 〉 Conclusions: 〈 /i 〉 In the Taiwanese, there is an association between SNP RS2200733 – but not RS10033464 – and the development of AF. Based on a recessive model of inheritance, individuals with SNP RS2200733 genotype CC are at a lesser risk of developing AF.
    Type of Medium: Online Resource
    ISSN: 0008-6312 , 1421-9751
    URL: Article
    DOI: 10.1159/000318172
    RVK:
    XA 36200
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2010
    detail.hit.zdb_id: 1482041-9
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