In:
Organic Chemistry Frontiers, Royal Society of Chemistry (RSC), Vol. 9, No. 8 ( 2022), p. 2169-2175
Abstract:
We report here a radical hydrotrifluoromethylation of ynamides to provide an alternative route toward β-CF 3 enamides. By using PhICF 3 Cl as the CF 3 reagent and DMF as the H-donor, the reaction occurred smoothly in the presence of NaH at room temperature. Further reduction of the resulting β-CF 3 enamides efficiently delivered β-CF 3 amines. Gram-scale synthesis was conducted to demonstrate the practicability of the method.
Type of Medium:
Online Resource
ISSN:
2052-4129
Language:
English
Publisher:
Royal Society of Chemistry (RSC)
Publication Date:
2022
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