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  • Royal Society of Chemistry (RSC)  (27)
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  • Royal Society of Chemistry (RSC)  (27)
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  • 1
    Online Resource
    Online Resource
    A mechanistic study on the cellular uptake, intracellular trafficking, and antisense gene regulation of bottlebrush polymer-conjugated oligonucleotides
    Royal Society of Chemistry (RSC) ; 2023
    In:  RSC Chemical Biology Vol. 4, No. 2 ( 2023), p. 138-145
    Details
    In: RSC Chemical Biology, Royal Society of Chemistry (RSC), Vol. 4, No. 2 ( 2023), p. 138-145
    Abstract: We have developed a non-cationic transfection vector in the form of bottlebrush polymer-antisense oligonucleotide (ASO) conjugates. Termed pacDNA (polymer-assisted compaction of DNA), these agents show improved biopharmaceutical characteristics and antisense potency in vivo while suppressing non-antisense side effects. Nonetheless, there still is a lack of the mechanistic understanding of the cellular uptake, subcellular trafficking, and gene knockdown with pacDNA. Here, we show that the pacDNA enters human non-small cell lung cancer cells (NCI-H358) predominantly by scavenger receptor-mediated endocytosis and macropinocytosis and trafficks via the endolysosomal pathway within the cell. The pacDNA significantly reduces a target gene expression (KRAS) in the protein level but not in the mRNA level, despite that the transfection of certain free ASOs causes ribonuclease H1 (RNase H)-dependent degradation of KRAS mRNA. In addition, the antisense activity of pacDNA is independent of ASO chemical modification, suggesting that the pacDNA always functions as a steric blocker.
    Type of Medium: Online Resource
    ISSN: 2633-0679
    URL: Article
    DOI: 10.1039/D2CB00149G
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2023
    detail.hit.zdb_id: 3037398-0
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  • 2
    Online Resource
    Online Resource
    A 3D graphene oxide microchip and a Au-enwrapped silica nanocomposite-based supersandwich cytosensor toward capture and analysis of circulating tumor cells
    Royal Society of Chemistry (RSC) ; 2015
    In:  Nanoscale Vol. 7, No. 39 ( 2015), p. 16354-16360
    Details
    In: Nanoscale, Royal Society of Chemistry (RSC), Vol. 7, No. 39 ( 2015), p. 16354-16360
    Type of Medium: Online Resource
    ISSN: 2040-3364 , 2040-3372
    URL: Article
    DOI: 10.1039/C5NR04798F
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2015
    detail.hit.zdb_id: 2515664-0
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  • 3
    Online Resource
    Online Resource
    Influence of reduction temperature on Pt–ZrO 2 interfaces for the gas-phase hydrogenation of acetone to isopropanol
    Royal Society of Chemistry (RSC) ; 2023
    In:  Catalysis Science & Technology Vol. 13, No. 9 ( 2023), p. 2675-2684
    Details
    In: Catalysis Science & Technology, Royal Society of Chemistry (RSC), Vol. 13, No. 9 ( 2023), p. 2675-2684
    Abstract: The gas-phase hydrogenation of acetone to isopropanol is an environmentally benign process relevant to chemical, energy and medical fields, but the catalysts working at low temperatures and pressures remain challenging. Herein, we show that the intensified gas-phase hydrogenation of acetone to isopropanol occurs at Pt–ZrO 2 interfaces and the catalytic performance can be influenced by reduction temperature. The catalytic activity of the Pt–ZrO 2 interface increases with the increase in reduction temperature to 200 °C and is nearly unchanged with further reduction to 300 °C due to the stability of the Pt–ZrO 2 interface. For example, Pt/ZrO 2 reduced at 200 °C with the highly active Pt–ZrO 2 interface delivers 92% acetone conversion with 98% isopropanol selectivity at 80 °C, a weight hourly space velocity of 10 h −1 , a H 2 /acetone molar ratio of 2, and 0.1 MPa, due to the high Pt 0 and oxygen vacancy content. A series of electron microscopic, thermal, and spectroscopic analyses testify that acetone could be efficiently adsorbed and activated at the Pt–ZrO 2 interface. This study particularly investigates the influence of reduction temperature on acetone adsorption and H 2 activation at the Pt–ZrO 2 interface, establishing the foundation for the rational design of high-cost performance catalysts for aldehyde/ketone hydrogenation and other reactions.
    Type of Medium: Online Resource
    ISSN: 2044-4753 , 2044-4761
    URL: Article
    DOI: 10.1039/D2CY02139K
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2023
    detail.hit.zdb_id: 2595090-3
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  • 4
    Online Resource
    Online Resource
    Prebiotic inulin nanocoating for pancreatic islet surface engineering
    Royal Society of Chemistry (RSC) ; 2023
    In:  Biomaterials Science Vol. 11, No. 4 ( 2023), p. 1470-1485
    Details
    In: Biomaterials Science, Royal Society of Chemistry (RSC), Vol. 11, No. 4 ( 2023), p. 1470-1485
    Abstract: Pancreatic islet surface engineering has been proposed as an “easy-to-adopt” approach to enhance post-transplantation islet engraftment for treatment against diabetes. Inulin is an FDA-approved dietary prebiotic with reported anti-diabetic, anti-inflammatory, anti-hypoxic and pro-angiogenic properties. We therefore assessed whether inulin would be a viable option for islet surface engineering. Inulin was oxidized to generate inulin-CHO, which would bind to the cell membrane via covalent bond formation between –CHO and –NH 2 across the islet cell membrane. In vitro assessments demonstrated enhanced islet viability and better glucose-induced insulin secretion from inulin-coated (5 mg mL −1 ) islets, which was accompanied by enhanced revascularization, shown as significantly enhanced tube formation and branching of islet endothelial MS1 cells following co-culture with inulin-coated islets. Reduction of cytokine-induced cell death was also observed from inulin-coated islets following exposure to pro-inflammatory cytokine LPS. LPS-induced ROS production was significantly dampened by 44% in inulin-coated islets when compared to controls. RNA-seq analysis of inulin-coated and control islets identified expression alterations of genes involved in islet function, vascular formation and immune regulation, supporting the positive impact of inulin on islet preservation. In vivo examination using streptozotocin (STZ)-induced hyperglycemic mice further showed moderately better maintained plasma glucose levels in mice received transplantation of inulin-coated islets, attributable to ameliorated CD45 + immune cell infiltration and improved in vivo graft vascularization. We therefore propose islet surface engineering with inulin as safe and beneficial, and further assessment is required to verify its applicability in clinical islet transplantation.
    Type of Medium: Online Resource
    ISSN: 2047-4830 , 2047-4849
    URL: Article
    DOI: 10.1039/D2BM01009G
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2023
    detail.hit.zdb_id: 2693928-9
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  • 5
    Online Resource
    Online Resource
    Importance of spin-triplet excited-state character in the reverse intersystem crossing process of spiro-based TADF emitters
    Royal Society of Chemistry (RSC) ; 2023
    In:  Journal of Materials Chemistry C Vol. 11, No. 18 ( 2023), p. 6119-6129
    Details
    In: Journal of Materials Chemistry C, Royal Society of Chemistry (RSC), Vol. 11, No. 18 ( 2023), p. 6119-6129
    Abstract: The reverse intersystem crossing (RISC) process is vital to improving exciton utilization and suppressing efficiency roll-off in thermally activated delayed fluorescence (TADF) materials. However, direct exciton transfer from the lowest triplet state (T 1 ) to the lowest excited singlet state (S 1 ) is not highly efficient when both states have the same charge transfer (CT) nature. Intervention of the local excitation character in T 1 states ( 3 LE) might be expected to enhance spin-flipping. In this work, the importance of the excited-state character of T 1 in the RISC process is demonstrated on the basis of the theoretical analysis of a series of donor–acceptor (D–A) type spiro-based TADF molecules. Five types of spin-triplet states featuring LE A , CT + LE A , CT, CT + LE D , and LE D are achieved through fine tuning the D–A interactions. The calculated results indicate that the triplet excited state features have significant effects on the spin–orbit coupling (SOC) constant and reorganization energy of the RISC process ( λ ), thus determining the RISC rate ( k RISC ). In particular, λ involved in the RISC is also important for k RISC , which is usually undervalued and not paid enough attention as the singlet–triplet energy gap. This work provides an in-depth understanding of the effect of the triplet excited-state character on the RISC process and establishes the structure–property relationship of spiro-based TADF molecules.
    Type of Medium: Online Resource
    ISSN: 2050-7526 , 2050-7534
    URL: Article
    DOI: 10.1039/D2TC05402G
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2023
    detail.hit.zdb_id: 2702245-6
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  • 6
    Online Resource
    Online Resource
    Color tuning of di-boron derived TADF emitters: molecular design and property prediction
    Royal Society of Chemistry (RSC) ; 2021
    In:  Journal of Materials Chemistry C Vol. 9, No. 42 ( 2021), p. 15309-15320
    Details
    In: Journal of Materials Chemistry C, Royal Society of Chemistry (RSC), Vol. 9, No. 42 ( 2021), p. 15309-15320
    Abstract: A class of thermally activated delayed fluorescence (TADF) molecules with electron-deficient diboron-derived units have been investigated by means of quantum chemical calculations. The modification of the electron acceptor by the fixation of 9,10-diboraanthracene (DBA) and its adjacent benzene rings and extension of the π-conjugation of DBA could effectively tune the electron-withdrawing ability, thus achieving the fluorescence emission in a visible spectrum color range. The reverse intersystem crossing (RISC) and radiative process of the investigated boron-containing compounds are analyzed in detail to reveal the TADF mechanism. The calculated results indicate that the RISC process of the emitter might be promoted by either the assistance of the non-adiabatic coupling effect or the dynamical molecular conformation changes activated at room temperature. This work provides an in-depth understanding of the TADF performance of organoboron compounds and establishes the structure–property relationship to screen highly efficient boron-based TADF materials.
    Type of Medium: Online Resource
    ISSN: 2050-7526 , 2050-7534
    URL: Article
    DOI: 10.1039/D1TC03345J
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2021
    detail.hit.zdb_id: 2702245-6
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  • 7
    Online Resource
    Online Resource
    Insights into efficient bacterial inactivation over nano Ag/graphdiyne: dual activation of molecular oxygen and water molecules
    Royal Society of Chemistry (RSC) ; 2023
    In:  Environmental Science: Nano
    Details
    In: Environmental Science: Nano, Royal Society of Chemistry (RSC)
    Abstract: The dual activation mechanism of molecular oxygen (O 2 ) and water (H 2 O) in the local structure of catalysts has not been elucidated yet. Herein, we report a strategy for manufacturing fully exposed Ag 4 sites in nano silver/graphdiyne (Ag/GDY) composites for activating O 2 and H 2 O. The synthesized nano Ag was uniformly anchored on the surface of GDY without any surfactant added, with an average particle size of 2.5 nm. The unique sp-hybrid C and triangular pore structure of GDY not only regulate the stable geometric structure of nano Ag, but also enhance the adsorption ability of Ag 4 sites for O 2 and H 2 O molecules in nano Ag/GDY. Electron spin resonance spectroscopy and density functional theory calculation results proved that O 2 is more favorable to synergistically promote the activation of H 2 O to generate reactive ·O 2 − and ·OH radicals on the nano Ag/GDY surfaces, leading to outstanding antibacterial activity. This work provides a simple strategy for the preparation of stable nano Ag and proposes to improve the catalytic oxidation activity by adjusting the local electronic structure of catalysts to activate O 2 and H 2 O.
    Type of Medium: Online Resource
    ISSN: 2051-8153 , 2051-8161
    URL: Article
    DOI: 10.1039/D3EN00480E
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2023
    detail.hit.zdb_id: 2758235-8
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  • 8
    Online Resource
    Online Resource
    Achieving ultrastability and efficient lithium storage capacity with high-energy iron( ii ) oxalate anode materials by compositing Ge nano-conductive sites
    Royal Society of Chemistry (RSC) ; 2023
    In:  Nanoscale Vol. 15, No. 6 ( 2023), p. 2700-2713
    Details
    In: Nanoscale, Royal Society of Chemistry (RSC), Vol. 15, No. 6 ( 2023), p. 2700-2713
    Abstract: Transition metal oxalates (TMOxs, represented by iron oxalate) have attracted considerable interest in anode materials due to their excellent lithium storage properties and consistent cyclic performance. Although investigations into their electrochemical capabilities and lithium storage mechanisms are gradually deepening, the complex and varied electrochemical reactions in the initial cycle, poor inherent conductivity, and high irreversible capacity constrain their further development. Herein, to solve the above-mentioned problems, we controlled the hydrothermal synthesis conditions of iron oxalate with the assistance of organic solvents, which induced the growth of iron oxalate crystals with nano Ge metal as the core. The metal Ge space sites compounded to the stacked iron oxalate particles act as conductive nodes and metal frames, which enhances both the strength of iron oxalate samples and electronic conductivity and lithium-ion diffusion inside the electrode materials. This special structure enhances the electrochemical activity of iron oxalates and improves their lithium storage capability. The iron oxalate @ nano Ge metal composite (FCO@Ge-1) exhibits an excellent cycling performance and an appreciable reversible specific capacity (1090 mA h g −1 after 200 cycles at 1 A g −1 ). The obvious polarization and variation of the electrochemical reaction in the initial cycle of iron oxalate are reduced by compositing nano Ge metal. It is demonstrated that nano Ge metal can promote reversible capacity retention from 67.72% to 80.69% in the early cycles. The distinctive structure of iron oxalate @ nano Ge metal composite provides a fresh pathway to enhance oxalate electrochemical reversible lithium storage activity and develop high-energy electrode material by constructing composite space conductive sites.
    Type of Medium: Online Resource
    ISSN: 2040-3364 , 2040-3372
    URL: Article
    DOI: 10.1039/D2NR06422G
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2023
    detail.hit.zdb_id: 2515664-0
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  • 9
    Online Resource
    Online Resource
    d -Glucosamine production from chitosan hydrolyzation over a glucose-derived solid acid catalyst
    Royal Society of Chemistry (RSC) ; 2018
    In:  RSC Advances Vol. 8, No. 10 ( 2018), p. 5608-5613
    Details
    In: RSC Advances, Royal Society of Chemistry (RSC), Vol. 8, No. 10 ( 2018), p. 5608-5613
    Type of Medium: Online Resource
    ISSN: 2046-2069
    URL: Article
    DOI: 10.1039/C7RA12490B
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2018
    detail.hit.zdb_id: 2623224-8
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  • 10
    Online Resource
    Online Resource
    Realization of switching between TADF and HLCT emissions through modulation of the intramolecular charge transfer character
    Royal Society of Chemistry (RSC) ; 2022
    In:  Journal of Materials Chemistry C Vol. 10, No. 36 ( 2022), p. 13124-13136
    Details
    In: Journal of Materials Chemistry C, Royal Society of Chemistry (RSC), Vol. 10, No. 36 ( 2022), p. 13124-13136
    Abstract: A facile molecular design strategy for switching between thermally activated delayed fluorescence (TADF) and hybridized local and charge transfer (HLCT) emissions has been proposed on the basis of the DFT calculations. Donor–acceptor (D–A) type molecular assemblies with suitable electron acceptor units (4-phenylbenzo[ c ][1,2,5] thiadiazole (BZP) or 9-borafluorene (BF)) and donor fragments with different electron-donating abilities could effectively tune the proportion of intramolecular charge transfer character in the excited state, thus realizing both HLCT and TADF emissions by utilizing hot and cold excitons through reverse intersystem crossing (RISC) channels. The excited-state properties are analyzed in the theoretical framework of the state hybridization to reveal the intrinsic structure–property relationships between HLCT and TADF molecules. This work provides an in-depth understanding of the excited-state properties of TADF/HLCT molecules and offers an easy way to design both HLCT and TADF molecules together.
    Type of Medium: Online Resource
    ISSN: 2050-7526 , 2050-7534
    URL: Article
    DOI: 10.1039/D2TC02896D
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2022
    detail.hit.zdb_id: 2702245-6
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