In:
New Journal of Chemistry, Royal Society of Chemistry (RSC), Vol. 47, No. 39 ( 2023), p. 18485-18491
Abstract:
The role of tellurium in medicinal chemistry has recently grown in importance due to the discovery of the anticancer properties of SAS and AS-101, two inorganic compounds based on Te( iv ). Here we describe an unprecedented isolation of a series of tetramethyl-dihydroxazole tellurium hexachloride salts whose structure has been indentified and characterised with several techniques including X-ray crystallography. The novelty resides on the role of tellurium that mediate the cyclisation of 1,1,2,2-tetramethylethylene into duhydroxazole in the presence of nitriles. Reaction mechanism, physiological stability and preliminary cytotoxicity results are discussed.
Type of Medium:
Online Resource
ISSN:
1144-0546
,
1369-9261
Language:
English
Publisher:
Royal Society of Chemistry (RSC)
Publication Date:
2023
detail.hit.zdb_id:
1472933-7
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