In:
Organic Chemistry Frontiers, Royal Society of Chemistry (RSC), Vol. 9, No. 9 ( 2022), p. 2549-2556
Abstract:
Three new sesquiterpene dimers, commiphoratones C–E (1–3), unprecedented carbon skeletons possessing a spiro center, were isolated from Resina commiphora . Their structures were assigned by spectroscopic methods, NMR chemical shifts and ECD calculations, and X-ray diffraction analysis. The framework of 1–3 represents a rare ring system of 10/6/5/3 between highly oxidized germacrane sesquiterpene and bicyclic sesquiterpene containing a bicyclo[3.1.0]hexane core via a [2 + 4] cycloaddition reaction. A plausible biosynthetic pathway for 1–3 is also proposed. Biological studies showed that they reduce cellular lipid accumulation in metabolism of fatty acids by r egulating the AMPK/ACC pathway in hepatocytes.
Type of Medium:
Online Resource
ISSN:
2052-4129
Language:
English
Publisher:
Royal Society of Chemistry (RSC)
Publication Date:
2022
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