In:
New Journal of Chemistry, Royal Society of Chemistry (RSC), Vol. 47, No. 33 ( 2023), p. 15658-15665
Kurzfassung:
Six pairs of enantiomeric dihydrobenzofuran-type lignanamides consisting of nine undescribed compounds (1a, 2a/2b–3a, and 4b–6a/6b), along with a previously undescribed racemic mixture (7), were isolated from Solanum lyratum (Solanaceae), and the separations of the enantiomers were accomplished by chiral-phase HPLC. The structures of these undescribed compounds were elucidated via analysis of spectroscopic data, and a Rh 2 (OCOCF 3 ) 4 -induced circular dichroism (ICD) method. All isolated compounds were assessed for neuroprotective activities in H 2 O 2 -induced human neuroblastoma SH-SY5Y cells, and acetylcholinesterase (AChE) inhibitory activities. Among the tested isolates, 3b exhibited significant neuroprotective activity at 25 and 50 μmol L −1 , 2b, 4a, 6a, and 6b exhibited moderate neuroprotective effects at 12.5, 25, and 50 μmol L −1 , and 2a and 6a exerted relatively better AChE inhibitory activity. The molecular docking studies were successfully performed to illustrate the binding between compound 2a and the active sites of AChE.
Materialart:
Online-Ressource
ISSN:
1144-0546
,
1369-9261
Sprache:
Englisch
Verlag:
Royal Society of Chemistry (RSC)
Publikationsdatum:
2023
ZDB Id:
1472933-7
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