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  • Royal College of Psychiatrists  (4)
  • 1
    Online Resource
    Online Resource
    Impact of a cis -associated gene expression SNP on chromosome 20q11.22 on bipolar disorder susceptibility, hippocampal structure and cognitive performance
    Royal College of Psychiatrists ; 2016
    In:  British Journal of Psychiatry Vol. 208, No. 2 ( 2016-02), p. 128-137
    Details
    In: British Journal of Psychiatry, Royal College of Psychiatrists, Vol. 208, No. 2 ( 2016-02), p. 128-137
    Abstract: Bipolar disorder is a highly heritable polygenic disorder. Recent enrichment analyses suggest that there may be true risk variants for bipolar disorder in the expression quantitative trait loci (eQTL) in the brain. Aims We sought to assess the impact of eQTL variants on bipolar disorder risk by combining data from both bipolar disorder genome-wide association studies (GWAS) and brain eQTL. Method To detect single nucleotide polymorphisms (SNPs) that influence expression levels of genes associated with bipolar disorder, we jointly analysed data from a bipolar disorder GWAS (7481 cases and 9250 controls) and a genome-wide brain (cortical) eQTL (193 healthy controls) using a Bayesian statistical method, with independent follow-up replications. The identified risk SNP was then further tested for association with hippocampal volume ( n = 5775) and cognitive performance ( n = 342) among healthy individuals. Results Integrative analysis revealed a significant association between a brain eQTL rs6088662 on chromosome 20q11.22 and bipolar disorder (log Bayes factor = 5.48; bipolar disorder P = 5.85×10 –5 ). Follow-up studies across multiple independent samples confirmed the association of the risk SNP (rs6088662) with gene expression and bipolar disorder susceptibility ( P = 3.54×10 –8 ). Further exploratory analysis revealed that rs6088662 is also associated with hippocampal volume and cognitive performance in healthy individuals. Conclusions Our findings suggest that 20q11.22 is likely a risk region for bipolar disorder; they also highlight the informative value of integrating functional annotation of genetic variants for gene expression in advancing our understanding of the biological basis underlying complex disorders, such as bipolar disorder.
    Type of Medium: Online Resource
    ISSN: 0007-1250 , 1472-1465
    URL: Article
    DOI: 10.1192/bjp.bp.114.156976
    RVK:
    XA 10000
    Language: English
    Publisher: Royal College of Psychiatrists
    Publication Date: 2016
    detail.hit.zdb_id: 2021500-9
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  • 2
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    Interaction between the FTO gene, body mass index and depression: meta-analysis of 13701 individuals
    Royal College of Psychiatrists ; 2017
    In:  British Journal of Psychiatry Vol. 211, No. 2 ( 2017-08), p. 70-76
    Details
    In: British Journal of Psychiatry, Royal College of Psychiatrists, Vol. 211, No. 2 ( 2017-08), p. 70-76
    Abstract: Depression and obesity are highly prevalent, and major impacts on public health frequently co-occur. Recently, we reported that having depression moderates the effect of the FTO gene, suggesting its implication in the association between depression and obesity. Aims To confirm these findings by investigating the FTO polymorphism rs9939609 in new cohorts, and subsequently in a meta-analysis. Method The sample consists of 6902 individuals with depression and 6799 controls from three replication cohorts and two original discovery cohorts. Linear regression models were performed to test for association between rs9939609 and body mass index (BMI), and for the interaction between rs9939609 and depression status for an effect on BMI. Fixed and random effects meta-analyses were performed using METASOFT. Results In the replication cohorts, we observed a significant interaction between FTO , BMI and depression with fixed effects meta-analysis (β=0.12, P = 2.7 × 10 −4 ) and with the Han/Eskin random effects method ( P = 1.4 × 10 −7 ) but not with traditional random effects (β = 0.1, P = 0.35). When combined with the discovery cohorts, random effects meta-analysis also supports the interaction (β = 0.12, P = 0.027) being highly significant based on the Han/Eskin model ( P = 6.9 × 10 −8 ). On average, carriers of the risk allele who have depression have a 2.2% higher BMI for each risk allele, over and above the main effect of FTO. Conclusions This meta-analysis provides additional support for a significant interaction between FTO , depression and BMI, indicating that depression increases the effect of FTO on BMI. The findings provide a useful starting point in understanding the biological mechanism involved in the association between obesity and depression.
    Type of Medium: Online Resource
    ISSN: 0007-1250 , 1472-1465
    URL: Article
    DOI: 10.1192/bjp.bp.116.183475
    RVK:
    XA 10000
    Language: English
    Publisher: Royal College of Psychiatrists
    Publication Date: 2017
    detail.hit.zdb_id: 2021500-9
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  • 3
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    Relationship between obesity and the risk of clinically significant depression: Mendelian randomisation study
    Royal College of Psychiatrists ; 2014
    In:  British Journal of Psychiatry Vol. 205, No. 1 ( 2014-07), p. 24-28
    Details
    In: British Journal of Psychiatry, Royal College of Psychiatrists, Vol. 205, No. 1 ( 2014-07), p. 24-28
    Abstract: Obesity has been shown to be associated with depression and it has been suggested that higher body mass index (BMI) increases the risk of depression and other common mental disorders. However, the causal relationship remains unclear and Mendelian randomisation, a form of instrumental variable analysis, has recently been employed to attempt to resolve this issue. Aims To investigate whether higher BMI increases the risk of major depression. Method Two instrumental variable analyses were conducted to test the causal relationship between obesity and major depression in RADIANT, a large case–control study of major depression. We used a single nucleotide polymorphism (SNP) in FTO and a genetic risk score (GRS) based on 32 SNPs with well-established associations with BMI. Results Linear regression analysis, as expected, showed that individuals carrying more risk alleles of FTO or having higher score of GRS had a higher BMI. Probit regression suggested that higher BMI is associated with increased risk of major depression. However, our two instrumental variable analyses did not support a causal relationship between higher BMI and major depression ( FTO genotype: coefficient −0.03, 95% CI −0.18 to 0.13, P = 0.73; GRS: coefficient −0.02, 95% CI −0.11 to 0.07, P = 0.62). Conclusions Our instrumental variable analyses did not support a causal relationship between higher BMI and major depression. The positive associations of higher BMI with major depression in probit regression analyses might be explained by reverse causality and/or residual confounding.
    Type of Medium: Online Resource
    ISSN: 0007-1250 , 1472-1465
    URL: Article
    DOI: 10.1192/bjp.bp.113.130419
    RVK:
    XA 10000
    Language: English
    Publisher: Royal College of Psychiatrists
    Publication Date: 2014
    detail.hit.zdb_id: 2021500-9
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  • 4
    Online Resource
    Online Resource
    The association between self-reported and clinically determined hypomanic symptoms and the onset of major mood disorders
    Royal College of Psychiatrists ; 2017
    In:  BJPsych Open Vol. 3, No. 2 ( 2017-03), p. 71-77
    Details
    In: BJPsych Open, Royal College of Psychiatrists, Vol. 3, No. 2 ( 2017-03), p. 71-77
    Abstract: Hypomanic symptoms may be a useful predictor of mood disorder among young people at high risk for bipolar disorder. Aims To determine whether hypomanic symptoms differentiate offspring of parents with bipolar disorder (high risk) and offspring of well parents (control) and predict the development of mood episodes. Method High-risk and control offspring were prospectively assessed using semi-structured clinical interviews annually and completed the Hypomania Checklist-32 Revised (HCL-32). Clinically significant sub-threshold hypomanic symptoms (CSHS) were coded. Results HCL-32 total and active or elated scores were higher in control compared with high-risk offspring, whereas 14% of high-risk and 0% of control offspring had CSHS. High-risk offspring with CSHS had a fivefold increased risk of developing recurrent major depression ( P =0.0002). The median onset of CSHS in high-risk offspring was 16.4 (6–31) years and was before the onset of major mood episodes. Conclusions CSHS are precursors to major mood episodes in high-risk offspring and could identify individuals at ultra-high risk for developing bipolar disorder.
    Type of Medium: Online Resource
    ISSN: 2056-4724
    URL: Article
    DOI: 10.1192/bjpo.bp.116.004234
    Language: English
    Publisher: Royal College of Psychiatrists
    Publication Date: 2017
    detail.hit.zdb_id: 2829557-2
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