In:
Journal of Gastrointestinal and Liver Diseases, Romanian Society of Gastroenterology and Hepatology, Vol. 27, No. 1 ( 2018-03-31), p. 11-17
Abstract:
Aims: The aim of the study was to evaluate the rationale of blood pepsinogen (PG) testing in population based screening settings.Methods: Participants from a cross-sectional population-based study of cardiovascular risk factors in Latvia were invited to participate in the current study. Pepsinogen I and II were measured in blood samples taken during the initial study and at follow-up; upper gastrointestinal endoscopy was performed. There were three groups of patients: with moderately decreased (PG I 〈 70 ng/ml and PG I/PG II ratio 〈 3), with strongly decreased (PG I 〈 30 ng/ml and PG I/PG II ratio 〈 2), and with normal PG level. Biopsy with H. pylori detection was performed (updated Sydney system).Results: Results from 259 patients were analyzed. Pepsinogens were decreased in 133 (51.4%), H. pylori was positive in 177 (66.0%) cases. Mean age was significantly lower in patients with normal compared to strongly decreased PG level group (52.8 vs. 64.1 years, p 〈 0.001). Prevalence of severe corpus atrophy was higher in the strongly decreased compared to the normal PG test group: 7.0% vs. 0%; the same tendency was noted in the distribution of OLGA stages III-IV – 10.5% and 0.0%, OLGIM stages III-IV – 3.5% and 0%, and low-grade dysplasia – 15.8% and 2.4% (p 〈 0.05). Two cases of gastric cancer were found; both presented decreased PG levels. A strong association between H. pylori eradication and PG ratio dynamics was found (p 〈 0.05).Conclusions: All high-risk lesions were found in the decreased PG test groups; two cancer cases were revealed.However, PG demonstrated low specificity and low value of repeated testing. The value of PG as a sole test for gastric cancer risk is limited.
Type of Medium:
Online Resource
ISSN:
1842-1121
,
1841-8724
DOI:
10.15403/jgld.2014.1121.271.pep
Language:
Unknown
Publisher:
Romanian Society of Gastroenterology and Hepatology
Publication Date:
2018
detail.hit.zdb_id:
2253255-9
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