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  • 1
    Online Resource
    Online Resource
    Osteogenesis and biofilms formation on titanium surfaces submitted to oxygen plasma immersion ion implantation
    Research, Society and Development ; 2021
    In:  Research, Society and Development Vol. 10, No. 6 ( 2021-06-03), p. e37210615644-
    Details
    In: Research, Society and Development, Research, Society and Development, Vol. 10, No. 6 ( 2021-06-03), p. e37210615644-
    Abstract: The objectives of this study were to characterize titanium (Ti) surfaces treated by ion implantation by immersion in oxygen plasma (O-PIII) at different temperatures, correlating these implanted layers with therapeutic effects and with osteogenesis, as well as the formation of monotypic biofilms microbial. The groups were divided into: a) Ti (pre-treatment) b) Ti O-PIII at 400 ° C. c) Ti O-PIII at 500 ° C. d) Ti O-PIII at 600 ° C. The properties and surface characteristics were evaluated according to the roughness, texture, corrosion resistance, formation of new phases and the identification of chemical compounds present. Cellular analyzes investigated cell interaction, viability, total protein content, alkaline phosphatase and quantification of mineralized nodules using MG-63 cells. The formation of monotypic microbial biofilms, including P. aeruginosa, S. aureus, S. mutans and C. albicans were evaluated. The increase in surface roughness, corrosion resistance and oxygen content, leading to the formation of TiO2-rutile with more intense peaks and in greater numbers according to the increase in the substrate temperature, ionic implanted Ti samples was observed. There was also a significant increase in cell viability, total protein production, alkaline phosphatase activity and formation of mineralization nodules for the group treated with O-PIII at 600ºC compared to other groups, in addition to a reduction of microorganisms in the groups treated with O- PIII. Therefore, treatment with O-PIII at 600ºC in Ti grade IV showed favorable results for its use.
    Type of Medium: Online Resource
    ISSN: 2525-3409
    URL: Article
    DOI: 10.33448/rsd-v10i6.15644
    Language: Unknown
    Publisher: Research, Society and Development
    Publication Date: 2021
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Gene expression in implant surgery patients: a description of bone and inflammation markers
    Research, Society and Development ; 2021
    In:  Research, Society and Development Vol. 10, No. 3 ( 2021-03-22), p. e46910313650-
    Details
    In: Research, Society and Development, Research, Society and Development, Vol. 10, No. 3 ( 2021-03-22), p. e46910313650-
    Abstract: This research describes the gene expression of molecules related to inflammation and bone metabolism in all patients submitted to dental implant surgery attended at a Brazilian institution. A convenience sample was collected over 2 years. The bone samples were processed for extraction of total RNA and reverse transcription of cDNA. Relative quantification by real-time polymerase chain reaction of target genes was performed. The sample was characterized demographically and according heath conditions. The patients were grouped. The control group was composed of 17 healthy patients, 6 patients were included in the antihypertensive therapy group, 3 were smokers, another 3 were smokers and were under antihypertensive treatment, and 3 were ex-smokers (smoked for 10 years but had quit for at least 5 years). The ex-smoker group presented the highest values, and the Hypertensive group presented the lowest values of Macrophage colony-stimulating factor, Osteonectin, Bone Morphogenetic Protein II, and Integrin. All smokers demonstrated expression values comparable to the Control group. The highest expression values of Osteopontin, RUNX, and Alkaline Phosphatase were observed in the Hypertensive and the Smoker group, while the lowest values were found in the Hypertensive group. Smokers, Ex-smokers, and the Control group demonstrated similar values. As conclusion, gene downregulation was observed in patients under anti-hypertensive therapy. Smoke seems to reduce expression of genes involve in bone formation and increase genes responsible for resorptive activity. This pattern of genic expression may be involved in higher implant loss, observed in smokers. Stop smoke seems to return expression of some of these genes.
    Type of Medium: Online Resource
    ISSN: 2525-3409
    URL: Article
    DOI: 10.33448/rsd-v10i3.13650
    Language: Unknown
    Publisher: Research, Society and Development
    Publication Date: 2021
    Location Call Number Limitation Availability
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    Online Resource
  • 3
    Online Resource
    Online Resource
    O papel do tempo de irradiação local no processo de osseointegração em implantes
    Research, Society and Development ; 2022
    In:  Research, Society and Development Vol. 11, No. 8 ( 2022-06-08), p. e5711829923-
    Details
    In: Research, Society and Development, Research, Society and Development, Vol. 11, No. 8 ( 2022-06-08), p. e5711829923-
    Abstract: Objetivo: O objetivo deste estudo foi avaliar os efeitos da irradiação gama simulando uma dose total de radioterapia convencional em câncer de cabeça e pescoço na remodelação óssea e osseointegração de implantes em fêmures de ratos.Materiais e Métodos: Sessenta ratos receberam implantes de titânio rosqueado (Ti6Al4V) em ambos os fêmures. Os animais foram divididos: Sem Irradiação (N-Ir): Grupo N-Ir com implante somente; Irradiação Precoce (E-Ir): implante + irradiação após 24h; Irradiação Tardia (L-Ir): implante + irradiação após 4 semanas e Irradiação Prévia (P-Ir): irradiação + implante após 4 semanas. A irradiação foi fracionada em duas sessões de 15 Gy cada, totalizando 30 Gy. Os animais foram sacrificados aos 3 dias, 2 e 7 semanas após o tratamento. Marcadores imuno-histoquímicos Runx2 e coloração Picrosirius red, análise histomorfométrica (BIC e BAFO) e teste de torque reverso foram utilizados para avaliar a interface implante/osso e osso circundante. Os dados de Runx-2 (%), coloração picrosirius red (%), BIC e BAFO (%) e torque reverso (N/cm) foram submetidos aos testes ANOVA e Tukey para comparação entre grupos, ambos com α=0,05.Resultados: Os resultados mostraram que a expressão de Runx-2 foi diferente nos grupos irradiados quando comparados ao grupo N-Ir. Em geral, as análises de fibras colágenas nos grupos irradiados diferiram do grupo N-Ir. Em relação ao BIC, BAFO e teste de torque reverso, o grupo L-Ir apresentou resultados semelhantes ao grupo N-Ir, enquanto os demais grupos foram prejudicados pela radioterapia.Conclusões: A radiação ionizante afetou negativamente a remodelação óssea, e seu efeito depende de quando a radioterapia é aplicada, com retardo da osseointegração quando aplicada previamente ou próximo à cirurgia.
    Type of Medium: Online Resource
    ISSN: 2525-3409
    URL: Article
    DOI: 10.33448/rsd-v11i8.29923
    Language: Unknown
    Publisher: Research, Society and Development
    Publication Date: 2022
    Location Call Number Limitation Availability
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    Online Resource
  • 4
    Online Resource
    Online Resource
    Desafios e possibilidades para o ensino superior: uma experiência brasileira em tempos de COVID-19
    Research, Society and Development ; 2020
    In:  Research, Society and Development Vol. 9, No. 8 ( 2020-07-16)
    Details
    In: Research, Society and Development, Research, Society and Development, Vol. 9, No. 8 ( 2020-07-16)
    Abstract: A pandemia causada pelo novo coronavírus adquiriu grandes proporções e seu impacto na sociedade tem se tornado cada vez mais significativo. No que diz respeito ao ensino, as instituições buscaram nas estratégias de atividades educacionais remotas, uma alternativa para manter seus alunos em atividade, minimizando as consequências que as políticas de isolamento social poderiam acarretar nas atividades acadêmicas. Este estudo, de caráter descritivo, qualitativo e quantitativo, do tipo relato de experiência, foi elaborado a partir da necessidade de adequação repentina das estratégias pedagógicas na Disciplina de Histologia e Embriologia do Curso de Odontologia de uma universidade pública brasileira. Objetivou-se expor as diferentes possibilidades de estratégias e ferramentas pedagógicas que têm sido utilizadas, bem como analisar o desempenho acadêmico e engajamento dos estudantes. Os docentes da Disciplina buscaram não apenas soluções emergenciais temporárias para dar continuidade à Disciplina, mas se esforçaram em recriar um novo modelo educacional, considerando o uso de metodologias ativas de ensino para uma aprendizagem significativa, mediante o emprego virtual de estratégias pedagógicas e ferramentas digitais, oportunizando o desenvolvimento da autonomia e a auto responsabilidade dos estudantes. Os resultados mostraram engajamento e desempenho promissores dos estudantes, porém este estudo é limitado aos dados em um curto período, tornando necessário o desenvolvimento de estudos longitudinais para avaliar efetivamente os impactos desse modelo educacional não apenas no engajamento e desempenho dos estudantes, mas na sua aprendizagem e na qualidade da educação.
    Type of Medium: Online Resource
    ISSN: 2525-3409
    URL: Article
    DOI: 10.33448/rsd-v9i8.5970
    Language: Unknown
    Publisher: Research, Society and Development
    Publication Date: 2020
    Location Call Number Limitation Availability
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    Online Resource
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