In:
Interventional Cardiology Review, Radcliffe Media Media Ltd, Vol. 6, No. 2 ( 2011), p. 170-
Abstract:
The Mitralign system (Mitralign, Inc., Tewksbury, Massachusetts, US) is a set of devices approaching the posterior mitral annulus through the left ventricle (LV). Two pairs of surgical pledgets are delivered at the P1 and P3 site of the annulus. The paired pledgets are pulled together to decrease the annulus circumference, and the achieved plication is locked in place. In swine hearts the permanent implants, pledgets and locks, lack any adverse pathology such as necrosis, thrombosis, haemorrhage, mineralisation or exuberant inflammation, and the overall tissue response at 30-day follow-up is considered benign. The clinical experience is limited to a few patients enrolled in a first-in-man study. In a perfect candidate with relatively preserved LV function, moderately enlarged ventricle and limited leaflet tethering, Mitralign annuloplasty may reduce mitral regurgitation significantly from grade 4+ to grade 1+. More research and clinical trials are needed to understand this novel technique for percutaneous mitral valve repair.
Type of Medium:
Online Resource
ISSN:
1756-1477
DOI:
10.15420/icr.2011.6.2.170
Language:
English
Publisher:
Radcliffe Media Media Ltd
Publication Date:
2011
detail.hit.zdb_id:
2813989-6
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