In:
PLOS Neglected Tropical Diseases, Public Library of Science (PLoS), Vol. 16, No. 4 ( 2022-4-20), p. e0010364-
Abstract:
Although Q fever has been widely reported in the rural areas of China, there is a paucity of data on the epidemiology and clinical characteristics of this disease in large metropolitan cities. In this study, we profile the epidemiology and clinical manifestations of Q fever from a tertiary hospital in Shenzhen, a Southern Chinese metropolitan city with a large immigrant population from other parts of China. A total of 14 patients were confirmed to have Q fever during a nine-year-and-six-month period, five of whom were retrospectively diagnosed during case review or incidentally picked up because of another research project on unexplained fever without localizing features. Some patients had the typical exposure histories and clinical features, while a few other patients had rare manifestations of Q fever, including one with heart failure and diffuse intracapillary proliferative glomerulonephritis, a patient presenting with a spontaneous bacterial peritonitis-like syndrome, and another one with concomitant Q fever and brucellosis. Using a combination of clinical manifestation, inflammatory marker levels, echocardiographic findings and serological or molecular test results, nine, three and two patients were diagnosed to have acute, chronic and convalescent Q fever, respectively. Seven, five and two patients were diagnosed to have Q fever by serological test, nested real-time PCR and next-generation sequencing respectively. Diverse and atypical manifestations are associated with Q fever. The incidence of Q fever is likely to be underestimated. Next-generation sequencing is becoming an important diagnostic modality for culture-negative infections, particularly those that the physicians fail to recognize clinically, such as Q fever.
Type of Medium:
Online Resource
ISSN:
1935-2735
DOI:
10.1371/journal.pntd.0010364
DOI:
10.1371/journal.pntd.0010364.g001
DOI:
10.1371/journal.pntd.0010364.g002
DOI:
10.1371/journal.pntd.0010364.t001
DOI:
10.1371/journal.pntd.0010364.t002
DOI:
10.1371/journal.pntd.0010364.s001
DOI:
10.1371/journal.pntd.0010364.s002
DOI:
10.1371/journal.pntd.0010364.s003
DOI:
10.1371/journal.pntd.0010364.s004
DOI:
10.1371/journal.pntd.0010364.s005
DOI:
10.1371/journal.pntd.0010364.r001
DOI:
10.1371/journal.pntd.0010364.r002
DOI:
10.1371/journal.pntd.0010364.r003
DOI:
10.1371/journal.pntd.0010364.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2429704-5
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