In:
PLOS Pathogens, Public Library of Science (PLoS), Vol. 16, No. 12 ( 2020-12-14), p. e1009019-
Abstract:
Testicular invasion and persistence are features of Zika virus (ZIKV), but their mechanisms are still unknown. Here, we showed that S100A4+ macrophages, a myeloid macrophage subpopulation with susceptibility to ZIKV infection, facilitated ZIKV invasion and persistence in the seminiferous tubules. In ZIKV-infected mice, S100A4+ macrophages were specifically recruited into the interstitial space of testes and differentiated into interferon-γ-expressing M1 macrophages. With interferon-γ mediation, S100A4+ macrophages down-regulated Claudin-1 expression and induced its redistribution from the cytosol to nucleus, thus increasing the permeability of the blood-testis barrier which facilitated S100A4+ macrophages invasion into the seminiferous tubules. Intraluminal S100A4+ macrophages were segregated from CD8+ T cells and consequently helped ZIKV evade cellular immunity. As a result, ZIKV continued to replicate in intraluminal S100A4+ macrophages even when the spermatogenic cells disappeared. Deficiencies in S100A4 or interferon-γ signaling both reduced ZIKV infection in the seminiferous tubules. These results demonstrated crucial roles of S100A4+ macrophages in ZIKV infection in testes.
Type of Medium:
Online Resource
ISSN:
1553-7374
DOI:
10.1371/journal.ppat.1009019
DOI:
10.1371/journal.ppat.1009019.g001
DOI:
10.1371/journal.ppat.1009019.g002
DOI:
10.1371/journal.ppat.1009019.g003
DOI:
10.1371/journal.ppat.1009019.g004
DOI:
10.1371/journal.ppat.1009019.g005
DOI:
10.1371/journal.ppat.1009019.g006
DOI:
10.1371/journal.ppat.1009019.g007
DOI:
10.1371/journal.ppat.1009019.g008
DOI:
10.1371/journal.ppat.1009019.s001
DOI:
10.1371/journal.ppat.1009019.s002
DOI:
10.1371/journal.ppat.1009019.s003
DOI:
10.1371/journal.ppat.1009019.s004
DOI:
10.1371/journal.ppat.1009019.s005
DOI:
10.1371/journal.ppat.1009019.s006
DOI:
10.1371/journal.ppat.1009019.s007
DOI:
10.1371/journal.ppat.1009019.s008
DOI:
10.1371/journal.ppat.1009019.s009
DOI:
10.1371/journal.ppat.1009019.s010
DOI:
10.1371/journal.ppat.1009019.s011
DOI:
10.1371/journal.ppat.1009019.s012
DOI:
10.1371/journal.ppat.1009019.s013
DOI:
10.1371/journal.ppat.1009019.r001
DOI:
10.1371/journal.ppat.1009019.r002
DOI:
10.1371/journal.ppat.1009019.r003
DOI:
10.1371/journal.ppat.1009019.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2020
detail.hit.zdb_id:
2205412-1
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