In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 11 ( 2022-11-2), p. e0276944-
Abstract:
Long-term exposure to low polycyclic aromatic hydrocarbon (PAH) concentration may ave detrimental effects, including changing platelet indices. Effects of chronic exposure to low PAH concentrations have been evaluated in cross-sectional, but not in longitudinal studies, to date. We aimed to assess the effects of long-term exposure to the low-concentration PAHs on alterations in platelet indices in the Chinese population. During 2014–2017, we enrolled 222 participants who had lived in a village in northern China, 1–2 km downwind from a coal plant, for more than 25 years, but who were not employed by the plant or related businesses. During three follow-ups, annually in June, demographic information and urine and blood samples were collected. Eight PAHs were tested: namely 2-hydroxynaphthalene, 1-hydroxynaphthalene, 2-hydroxyfluorene, 9-hydroxyfluorene (9-OHFlu), 2-hydroxyphenanthrene (2-OHPh), 1-hydroxyphenanthrene (1-OHPh), 1-hydroxypyrene (1-OHP), and 3-hydroxybenzo [a] pyrene. Five platelet indices were measured: platelet count (PLT), platelet distribution width (PDW), mean platelet volume (MPV), platelet crit, and the platelet-large cell ratio. Generalized mixed and generalized linear mixed models were used to estimate correlations between eight urinary PAH metabolites and platelet indices. Model 1 assessed whether these correlations varied over time. Models 2 and 3 adjusted for additional personal information and personal habits. We found the following significant correlations: 2-OHPh (Model1 β 1 = 18.06, Model2 β 2 = 18.54, Model β 3 = 18.54), 1-OHPh (β 1 = 16.43, β 2 = 17.42, β 3 = 17.42), 1-OHP(β 1 = 13.93, β 2 = 14.03, β 3 = 14.03) with PLT, as well as 9-OHFlu with PDW and MPV (odds ratio or Model3 OR PDW [95%CI] = 1.64[1.3–2.06] , OR MPV [95%CI] = 1.33[1.19–1.48] ). Long-term exposure to low concentrations of PAHs, indicated by2-OHPh, 1-OHPh, 1-OHP, and 9-OHFlu, as urinary biomarkers, affects PLT, PDW, and MPV. 9-OHFlu increased both PDW and MPV after elimination of the effects of other PAH exposure modes.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0276944
DOI:
10.1371/journal.pone.0276944.g001
DOI:
10.1371/journal.pone.0276944.g002
DOI:
10.1371/journal.pone.0276944.g003
DOI:
10.1371/journal.pone.0276944.t001
DOI:
10.1371/journal.pone.0276944.t002
DOI:
10.1371/journal.pone.0276944.t003
DOI:
10.1371/journal.pone.0276944.s001
DOI:
10.1371/journal.pone.0276944.s002
DOI:
10.1371/journal.pone.0276944.s003
DOI:
10.1371/journal.pone.0276944.s004
DOI:
10.1371/journal.pone.0276944.s005
DOI:
10.1371/journal.pone.0276944.s006
DOI:
10.1371/journal.pone.0276944.s007
DOI:
10.1371/journal.pone.0276944.s008
DOI:
10.1371/journal.pone.0276944.s009
DOI:
10.1371/journal.pone.0276944.r001
DOI:
10.1371/journal.pone.0276944.r002
DOI:
10.1371/journal.pone.0276944.r003
DOI:
10.1371/journal.pone.0276944.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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