In:
PLOS Biology, Public Library of Science (PLoS), Vol. 21, No. 7 ( 2023-7-5), p. e3001862-
Abstract:
The induction of ferroptosis in tumor cells is one of the most important mechanisms by which tumor progression can be inhibited; however, the specific regulatory mechanism underlying ferroptosis remains unclear. In this study, we found that transcription factor HBP1 has a novel function of reducing the antioxidant capacity of tumor cells. We investigated the important role of HBP1 in ferroptosis. HBP1 down-regulates the protein levels of UHRF1 by inhibiting the expression of the UHRF1 gene at the transcriptional level. Reduced levels of UHRF1 have been shown to regulate the ferroptosis-related gene CDO1 by epigenetic mechanisms, thus up-regulating the level of CDO1 and increasing the sensitivity of hepatocellular carcinoma and cervical cancer cells to ferroptosis. On this basis, we constructed metal-polyphenol-network coated HBP1 nanoparticles by combining biological and nanotechnological. MPN-HBP1 nanoparticles entered tumor cells efficiently and innocuously, induced ferroptosis, and inhibited the malignant proliferation of tumors by regulating the HBP1-UHRF1-CDO1 axis. This study provides a new perspective for further research on the regulatory mechanism underlying ferroptosis and its potential role in tumor therapy.
Type of Medium:
Online Resource
ISSN:
1545-7885
DOI:
10.1371/journal.pbio.3001862
DOI:
10.1371/journal.pbio.3001862.g001
DOI:
10.1371/journal.pbio.3001862.g002
DOI:
10.1371/journal.pbio.3001862.g003
DOI:
10.1371/journal.pbio.3001862.g004
DOI:
10.1371/journal.pbio.3001862.g005
DOI:
10.1371/journal.pbio.3001862.g006
DOI:
10.1371/journal.pbio.3001862.g007
DOI:
10.1371/journal.pbio.3001862.g008
DOI:
10.1371/journal.pbio.3001862.s001
DOI:
10.1371/journal.pbio.3001862.s002
DOI:
10.1371/journal.pbio.3001862.s003
DOI:
10.1371/journal.pbio.3001862.s004
DOI:
10.1371/journal.pbio.3001862.s005
DOI:
10.1371/journal.pbio.3001862.s006
DOI:
10.1371/journal.pbio.3001862.s007
DOI:
10.1371/journal.pbio.3001862.s008
DOI:
10.1371/journal.pbio.3001862.s009
DOI:
10.1371/journal.pbio.3001862.s010
DOI:
10.1371/journal.pbio.3001862.s011
DOI:
10.1371/journal.pbio.3001862.s012
DOI:
10.1371/journal.pbio.3001862.r001
DOI:
10.1371/journal.pbio.3001862.r002
DOI:
10.1371/journal.pbio.3001862.r003
DOI:
10.1371/journal.pbio.3001862.r004
DOI:
10.1371/journal.pbio.3001862.r005
DOI:
10.1371/journal.pbio.3001862.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2126773-X
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