In:
PLOS Pathogens, Public Library of Science (PLoS), Vol. 17, No. 1 ( 2021-1-11), p. e1008770-
Abstract:
Environments such as light condition influence the spread of infectious diseases by affecting insect vector behavior. However, whether and how light affects the host defense which further affects insect preference and performance, remains unclear, nor has been demonstrated how pathogens co-adapt light condition to facilitate vector transmission. We previously showed that begomoviral βC1 inhibits MYC2-mediated jasmonate signaling to establish plant-dependent mutualism with its insect vector. Here we show red-light as an environmental catalyzer to promote mutualism of whitefly-begomovirus by stabilizing βC1, which interacts with PHYTOCHROME-INTERACTING FACTORS (PIFs) transcription factors. PIFs positively control plant defenses against whitefly by directly binding to the promoter of terpene synthase genes and promoting their transcription. Moreover, PIFs interact with MYC2 to integrate light and jasmonate signaling and regulate the transcription of terpene synthase genes. However, begomovirus encoded βC1 inhibits PIFs’ and MYC2’ transcriptional activity via disturbing their dimerization, thereby impairing plant defenses against whitefly-transmitted begomoviruses. Our results thus describe how a viral pathogen hijacks host external and internal signaling to enhance the mutualistic relationship with its insect vector.
Type of Medium:
Online Resource
ISSN:
1553-7374
DOI:
10.1371/journal.ppat.1008770
DOI:
10.1371/journal.ppat.1008770.g001
DOI:
10.1371/journal.ppat.1008770.g002
DOI:
10.1371/journal.ppat.1008770.g003
DOI:
10.1371/journal.ppat.1008770.g004
DOI:
10.1371/journal.ppat.1008770.g005
DOI:
10.1371/journal.ppat.1008770.g006
DOI:
10.1371/journal.ppat.1008770.g007
DOI:
10.1371/journal.ppat.1008770.g008
DOI:
10.1371/journal.ppat.1008770.s001
DOI:
10.1371/journal.ppat.1008770.s002
DOI:
10.1371/journal.ppat.1008770.s003
DOI:
10.1371/journal.ppat.1008770.s004
DOI:
10.1371/journal.ppat.1008770.s005
DOI:
10.1371/journal.ppat.1008770.s006
DOI:
10.1371/journal.ppat.1008770.s007
DOI:
10.1371/journal.ppat.1008770.s008
DOI:
10.1371/journal.ppat.1008770.s009
DOI:
10.1371/journal.ppat.1008770.s010
DOI:
10.1371/journal.ppat.1008770.s011
DOI:
10.1371/journal.ppat.1008770.s012
DOI:
10.1371/journal.ppat.1008770.s013
DOI:
10.1371/journal.ppat.1008770.s014
DOI:
10.1371/journal.ppat.1008770.r001
DOI:
10.1371/journal.ppat.1008770.r002
DOI:
10.1371/journal.ppat.1008770.r003
DOI:
10.1371/journal.ppat.1008770.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2205412-1
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