In:
PLOS Pathogens, Public Library of Science (PLoS), Vol. 17, No. 6 ( 2021-6-14), p. e1009647-
Abstract:
HIV-1 functional cure requires sustained viral suppression without antiretroviral therapy. While effector-memory CD8 + T lymphocytes are essential for viremia control, few vaccines elicit such cellular immunity that could be potently recalled upon viral infection. Here, we investigated a program death-1 (PD1)-based vaccine by fusion of simian immunodeficiency virus capsid antigen to soluble PD1. Homologous vaccinations suppressed setpoint viremia to undetectable levels in vaccinated macaques following a high-dose intravenous challenge by the pathogenic SHIV SF162P3CN . Poly-functional effector-memory CD8 + T cells were not only induced after vaccination, but were also recalled upon viral challenge for viremia control as determined by CD8 depletion. Vaccine-induced effector memory CD8 + subsets displayed high cytotoxicity-related genes by single-cell analysis. Vaccinees with sustained viremia suppression for over two years responded to boost vaccination without viral rebound. These results demonstrated that PD1-based vaccine-induced effector-memory CD8 + T cells were recalled by AIDS virus infection, providing a potential immunotherapy for functional cure.
Type of Medium:
Online Resource
ISSN:
1553-7374
DOI:
10.1371/journal.ppat.1009647
DOI:
10.1371/journal.ppat.1009647.g001
DOI:
10.1371/journal.ppat.1009647.g002
DOI:
10.1371/journal.ppat.1009647.g003
DOI:
10.1371/journal.ppat.1009647.g004
DOI:
10.1371/journal.ppat.1009647.g005
DOI:
10.1371/journal.ppat.1009647.g006
DOI:
10.1371/journal.ppat.1009647.s001
DOI:
10.1371/journal.ppat.1009647.s002
DOI:
10.1371/journal.ppat.1009647.s003
DOI:
10.1371/journal.ppat.1009647.s004
DOI:
10.1371/journal.ppat.1009647.s005
DOI:
10.1371/journal.ppat.1009647.s006
DOI:
10.1371/journal.ppat.1009647.s007
DOI:
10.1371/journal.ppat.1009647.s008
DOI:
10.1371/journal.ppat.1009647.s009
DOI:
10.1371/journal.ppat.1009647.s010
DOI:
10.1371/journal.ppat.1009647.s011
DOI:
10.1371/journal.ppat.1009647.s012
DOI:
10.1371/journal.ppat.1009647.s013
DOI:
10.1371/journal.ppat.1009647.s014
DOI:
10.1371/journal.ppat.1009647.s015
DOI:
10.1371/journal.ppat.1009647.r001
DOI:
10.1371/journal.ppat.1009647.r002
DOI:
10.1371/journal.ppat.1009647.r003
DOI:
10.1371/journal.ppat.1009647.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2205412-1
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