In:
PLOS Genetics, Public Library of Science (PLoS), Vol. 17, No. 5 ( 2021-5-4), p. e1009557-
Abstract:
Genome alteration signatures reflect recurring patterns caused by distinct endogenous or exogenous mutational events during the evolution of cancer. Signatures of single base substitution (SBS) have been extensively studied in different types of cancer. Copy number alterations are important drivers for the progression of multiple cancer. However, practical tools for studying the signatures of copy number alterations are still lacking. Here, a user-friendly open source bioinformatics tool “sigminer” has been constructed for copy number signature extraction, analysis and visualization. This tool has been applied in prostate cancer (PC), which is particularly driven by complex genome alterations. Five copy number signatures are identified from human PC genome with this tool. The underlying mutational processes for each copy number signature have been illustrated. Sample clustering based on copy number signature exposure reveals considerable heterogeneity of PC, and copy number signatures show improved PC clinical outcome association when compared with SBS signatures. This copy number signature analysis in PC provides distinct insight into the etiology of PC, and potential biomarkers for PC stratification and prognosis.
Type of Medium:
Online Resource
ISSN:
1553-7404
DOI:
10.1371/journal.pgen.1009557
DOI:
10.1371/journal.pgen.1009557.g001
DOI:
10.1371/journal.pgen.1009557.g002
DOI:
10.1371/journal.pgen.1009557.g003
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10.1371/journal.pgen.1009557.g004
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10.1371/journal.pgen.1009557.g005
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10.1371/journal.pgen.1009557.g006
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10.1371/journal.pgen.1009557.t001
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10.1371/journal.pgen.1009557.s001
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10.1371/journal.pgen.1009557.s002
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10.1371/journal.pgen.1009557.s003
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10.1371/journal.pgen.1009557.s004
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10.1371/journal.pgen.1009557.s005
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10.1371/journal.pgen.1009557.s006
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10.1371/journal.pgen.1009557.s007
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10.1371/journal.pgen.1009557.s008
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10.1371/journal.pgen.1009557.s009
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10.1371/journal.pgen.1009557.s010
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10.1371/journal.pgen.1009557.s011
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10.1371/journal.pgen.1009557.s012
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10.1371/journal.pgen.1009557.s013
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10.1371/journal.pgen.1009557.s014
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10.1371/journal.pgen.1009557.s015
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10.1371/journal.pgen.1009557.s016
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10.1371/journal.pgen.1009557.s017
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10.1371/journal.pgen.1009557.s018
DOI:
10.1371/journal.pgen.1009557.s019
DOI:
10.1371/journal.pgen.1009557.s020
DOI:
10.1371/journal.pgen.1009557.r001
DOI:
10.1371/journal.pgen.1009557.r002
DOI:
10.1371/journal.pgen.1009557.r003
DOI:
10.1371/journal.pgen.1009557.r004
DOI:
10.1371/journal.pgen.1009557.r005
DOI:
10.1371/journal.pgen.1009557.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2186725-2
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