In:
PLOS Genetics, Public Library of Science (PLoS), Vol. 19, No. 7 ( 2023-7-31), p. e1010713-
Abstract:
We and others have previously shown that genetic association can be used to make causal connections between gene loci and small molecules measured by mass spectrometry in the bloodstream and in tissues. We identified a locus on mouse chromosome 7 where several phospholipids in liver showed strong genetic association to distinct gene loci. In this study, we integrated gene expression data with genetic association data to identify a single gene at the chromosome 7 locus as the driver of the phospholipid phenotypes. The gene encodes α/β-hydrolase domain 2 ( Abhd2 ), one of 23 members of the ABHD gene family. We validated this observation by measuring lipids in a mouse with a whole-body deletion of Abhd2 . The Abhd2 KO mice had a significant increase in liver levels of phosphatidylcholine and phosphatidylethanolamine. Unexpectedly, we also found a decrease in two key mitochondrial lipids, cardiolipin and phosphatidylglycerol, in male Abhd2 KO mice. These data suggest that Abhd2 plays a role in the synthesis, turnover, or remodeling of liver phospholipids.
Type of Medium:
Online Resource
ISSN:
1553-7404
DOI:
10.1371/journal.pgen.1010713
DOI:
10.1371/journal.pgen.1010713.g001
DOI:
10.1371/journal.pgen.1010713.g002
DOI:
10.1371/journal.pgen.1010713.g003
DOI:
10.1371/journal.pgen.1010713.s001
DOI:
10.1371/journal.pgen.1010713.s002
DOI:
10.1371/journal.pgen.1010713.s003
DOI:
10.1371/journal.pgen.1010713.s004
DOI:
10.1371/journal.pgen.1010713.s005
DOI:
10.1371/journal.pgen.1010713.s006
DOI:
10.1371/journal.pgen.1010713.s007
DOI:
10.1371/journal.pgen.1010713.s008
DOI:
10.1371/journal.pgen.1010713.s009
DOI:
10.1371/journal.pgen.1010713.s010
DOI:
10.1371/journal.pgen.1010713.s011
DOI:
10.1371/journal.pgen.1010713.s012
DOI:
10.1371/journal.pgen.1010713.s013
DOI:
10.1371/journal.pgen.1010713.s014
DOI:
10.1371/journal.pgen.1010713.s015
DOI:
10.1371/journal.pgen.1010713.s016
DOI:
10.1371/journal.pgen.1010713.s017
DOI:
10.1371/journal.pgen.1010713.s018
DOI:
10.1371/journal.pgen.1010713.s019
DOI:
10.1371/journal.pgen.1010713.s020
DOI:
10.1371/journal.pgen.1010713.r001
DOI:
10.1371/journal.pgen.1010713.r002
DOI:
10.1371/journal.pgen.1010713.r003
DOI:
10.1371/journal.pgen.1010713.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2186725-2
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