In:
PLOS Neglected Tropical Diseases, Public Library of Science (PLoS), Vol. 16, No. 3 ( 2022-3-14), p. e0010251-
Abstract:
The sand flea Tunga penetrans is one of the zoonotic agents of tungiasis, a parasitic skin disease of humans and animals. The dog is one of its main reservoirs. This negatively controlled, randomized, double-masked clinical trial evaluated the therapeutic and residual efficacy of fluralaner for treatment of dogs naturally infested with T . penetrans . Sixty-two dogs from an endemically affected community in Brazil were randomly assigned to either receive oral fluralaner (Bravecto chewable tablets) at a dose of 25 to 56 mg fluralaner/kg body weight, or no treatment (31 dogs per group). Dogs were clinically examined using a severity score for acute canine tungiasis (SCADT), parasitological examinations as defined by the Fortaleza classification, and pictures of lesions on days 0 (inclusion and treatment), 7 ± 2, 14 ± 2, 21 ± 2, 28 ± 2, 60 ± 7, 90 ± 7, 120 ± 7 and 150 ± 7. The percentage of parasite-free dogs after treatment was 〉 90% between days 14 and 90 post-treatment with 100% efficacy on study days 21, 28 and 60. Sand flea counts on fluralaner treated dogs were significantly lower (p 〈 0.025) than control dogs on all counts from day 7 to 120. The number of live sand fleas on treated dogs was reduced by 〉 90% on day 7, 〉 95% on days 14 and 90, and 100% from day 21 to 60, and with a significant difference between groups from day 7 to 120. From day 7 to day 120, mean SCADT scores were significantly reduced in treated dogs with a mean of 0.10 compared to 1.54 on day 120 in untreated dogs. Therefore, a single oral fluralaner administration is effective for treating and achieving long lasting ( 〉 12 weeks) prevention for tungiasis in dogs.
Type of Medium:
Online Resource
ISSN:
1935-2735
DOI:
10.1371/journal.pntd.0010251
DOI:
10.1371/journal.pntd.0010251.g001
DOI:
10.1371/journal.pntd.0010251.g002
DOI:
10.1371/journal.pntd.0010251.g003
DOI:
10.1371/journal.pntd.0010251.g004
DOI:
10.1371/journal.pntd.0010251.t001
DOI:
10.1371/journal.pntd.0010251.t002
DOI:
10.1371/journal.pntd.0010251.t003
DOI:
10.1371/journal.pntd.0010251.t004
DOI:
10.1371/journal.pntd.0010251.t005
DOI:
10.1371/journal.pntd.0010251.t006
DOI:
10.1371/journal.pntd.0010251.s001
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2429704-5
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