In:
PLOS Pathogens, Public Library of Science (PLoS), Vol. 17, No. 1 ( 2021-1-7), p. e1009080-
Abstract:
The fungal cell wall plays an essential role in maintaining cell morphology, transmitting external signals, controlling cell growth, and even virulence. Relaxation and irreversible stretching of the cell wall are the prerequisites of cell division and development, but they also inevitably cause cell wall stress. Both Mitotic Exit Network (MEN) and Cell Wall Integrity (CWI) are signaling pathways that govern cell division and cell stress response, respectively, how these pathways cross talk to govern and coordinate cellular growth, development, and pathogenicity remains not fully understood. We have identified MoSep1, MoDbf2, and MoMob1 as the conserved components of MEN from the rice blast fungus Magnaporthe oryzae . We have found that blocking cell division results in abnormal CWI signaling. In addition, we discovered that MoSep1 targets MoMkk1, a conserved key MAP kinase of the CWI pathway, through protein phosphorylation that promotes CWI signaling. Moreover, we provided evidence demonstrating that MoSep1-dependent MoMkk1 phosphorylation is essential for balancing cell division with CWI that maintains the dynamic stability required for virulence of the blast fungus.
Type of Medium:
Online Resource
ISSN:
1553-7374
DOI:
10.1371/journal.ppat.1009080
DOI:
10.1371/journal.ppat.1009080.g001
DOI:
10.1371/journal.ppat.1009080.g002
DOI:
10.1371/journal.ppat.1009080.g003
DOI:
10.1371/journal.ppat.1009080.g004
DOI:
10.1371/journal.ppat.1009080.g005
DOI:
10.1371/journal.ppat.1009080.g006
DOI:
10.1371/journal.ppat.1009080.g007
DOI:
10.1371/journal.ppat.1009080.g008
DOI:
10.1371/journal.ppat.1009080.g009
DOI:
10.1371/journal.ppat.1009080.g010
DOI:
10.1371/journal.ppat.1009080.g011
DOI:
10.1371/journal.ppat.1009080.s001
DOI:
10.1371/journal.ppat.1009080.s002
DOI:
10.1371/journal.ppat.1009080.s003
DOI:
10.1371/journal.ppat.1009080.s004
DOI:
10.1371/journal.ppat.1009080.s005
DOI:
10.1371/journal.ppat.1009080.s006
DOI:
10.1371/journal.ppat.1009080.s007
DOI:
10.1371/journal.ppat.1009080.s008
DOI:
10.1371/journal.ppat.1009080.s009
DOI:
10.1371/journal.ppat.1009080.s010
DOI:
10.1371/journal.ppat.1009080.s011
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2205412-1
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