In:
PLOS Genetics, Public Library of Science (PLoS), Vol. 17, No. 6 ( 2021-6-28), p. e1009653-
Abstract:
A single insulin receptor ( InR ) gene has been identified and extensively studied in model species ranging from nematodes to mice. However, most insects possess additional copies of InR , yet the functional significance, if any, of alternate InR s is unknown. Here, we used the wing-dimorphic brown planthopper (BPH) as a model system to query the role of a second InR copy in insects. NlInR2 resembled the BPH InR homologue ( NlInR1 ) in terms of nymph development and reproduction, but revealed distinct regulatory roles in fuel metabolism, lifespan, and starvation tolerance. Unlike a lethal phenotype derived from NlInR1 null, homozygous NlInR2 null mutants were viable and accelerated DNA replication and cell proliferation in wing cells, thus redirecting short-winged–destined BPHs to develop into long-winged morphs. Additionally, the proper expression of NlInR2 was needed to maintain symmetric vein patterning in wings. Our findings provide the first direct evidence for the regulatory complexity of the two InR paralogues in insects, implying the functionally independent evolution of multiple InR s in invertebrates.
Type of Medium:
Online Resource
ISSN:
1553-7404
DOI:
10.1371/journal.pgen.1009653
DOI:
10.1371/journal.pgen.1009653.g001
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10.1371/journal.pgen.1009653.g002
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10.1371/journal.pgen.1009653.g003
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10.1371/journal.pgen.1009653.g004
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10.1371/journal.pgen.1009653.g005
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10.1371/journal.pgen.1009653.g006
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10.1371/journal.pgen.1009653.s001
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10.1371/journal.pgen.1009653.s002
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10.1371/journal.pgen.1009653.s029
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10.1371/journal.pgen.1009653.r001
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10.1371/journal.pgen.1009653.r002
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10.1371/journal.pgen.1009653.r003
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10.1371/journal.pgen.1009653.r004
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10.1371/journal.pgen.1009653.r005
DOI:
10.1371/journal.pgen.1009653.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2186725-2
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