In:
PLOS Pathogens, Public Library of Science (PLoS), Vol. 18, No. 2 ( 2022-2-15), p. e1010288-
Abstract:
Urogenital schistosomiasis is caused by the blood fluke Schistosoma haematobium and is one of the most neglected tropical diseases worldwide, afflicting 〉 100 million people. It is characterised by granulomata, fibrosis and calcification in urogenital tissues, and can lead to increased susceptibility to HIV/AIDS and squamous cell carcinoma of the bladder. To complement available treatment programs and break the transmission of disease, sound knowledge and understanding of the biology and ecology of S . haematobium is required. Hybridisation/introgression events and molecular variation among members of the S . haematobium -group might effect important biological and/or disease traits as well as the morbidity of disease and the effectiveness of control programs including mass drug administration. Here we report the first chromosome-contiguous genome for a well-defined laboratory line of this blood fluke. An exploration of this genome using transcriptomic data for all key developmental stages allowed us to refine gene models (including non-coding elements) and annotations, discover ‘new’ genes and transcription profiles for these stages, likely linked to development and/or pathogenesis. Molecular variation within S . haematobium among some geographical locations in Africa revealed unique genomic ‘signatures’ that matched species other than S . haematobium , indicating the occurrence of introgression events. The present reference genome (designated Shae.V3) and the findings from this study solidly underpin future functional genomic and molecular investigations of S . haematobium and accelerate systematic, large-scale population genomics investigations, with a focus on improved and sustained control of urogenital schistosomiasis.
Type of Medium:
Online Resource
ISSN:
1553-7374
DOI:
10.1371/journal.ppat.1010288
DOI:
10.1371/journal.ppat.1010288.g001
DOI:
10.1371/journal.ppat.1010288.g002
DOI:
10.1371/journal.ppat.1010288.g003
DOI:
10.1371/journal.ppat.1010288.g004
DOI:
10.1371/journal.ppat.1010288.t001
DOI:
10.1371/journal.ppat.1010288.t002
DOI:
10.1371/journal.ppat.1010288.t003
DOI:
10.1371/journal.ppat.1010288.t004
DOI:
10.1371/journal.ppat.1010288.s001
DOI:
10.1371/journal.ppat.1010288.s002
DOI:
10.1371/journal.ppat.1010288.s003
DOI:
10.1371/journal.ppat.1010288.s004
DOI:
10.1371/journal.ppat.1010288.s005
DOI:
10.1371/journal.ppat.1010288.s006
DOI:
10.1371/journal.ppat.1010288.s007
DOI:
10.1371/journal.ppat.1010288.s008
DOI:
10.1371/journal.ppat.1010288.s009
DOI:
10.1371/journal.ppat.1010288.s010
DOI:
10.1371/journal.ppat.1010288.s011
DOI:
10.1371/journal.ppat.1010288.s012
DOI:
10.1371/journal.ppat.1010288.s013
DOI:
10.1371/journal.ppat.1010288.s014
DOI:
10.1371/journal.ppat.1010288.s015
DOI:
10.1371/journal.ppat.1010288.s016
DOI:
10.1371/journal.ppat.1010288.s017
DOI:
10.1371/journal.ppat.1010288.s018
DOI:
10.1371/journal.ppat.1010288.s019
DOI:
10.1371/journal.ppat.1010288.s020
DOI:
10.1371/journal.ppat.1010288.r001
DOI:
10.1371/journal.ppat.1010288.r002
DOI:
10.1371/journal.ppat.1010288.r003
DOI:
10.1371/journal.ppat.1010288.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2205412-1
Permalink