In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 12 ( 2022-12-16), p. e0279315-
Kurzfassung:
In recent years, there has been increasing evidence that several lipid metabolism abnormalities play an important role in the pathogenesis of neurodegenerative diseases. However, it is still unclear which lipid metabolism abnormalities play the most important role in neurodegenerative diseases. Plasma lipid metabolomics (lipidomics) has been shown to be an unbiased method that can be used to explore lipid metabolism abnormalities in neurodegenerative diseases. Plasma lipidomics in neurodegenerative diseases has been performed only in idiopathic Parkinson’s disease (IPD) and Alzheimer’s disease (AD), and comprehensive studies are needed to clarify the pathogenesis. Methods In this study, we investigated plasma lipids using lipidomics in individuals with neurodegenerative diseases and healthy controls (CNs). Plasma lipidomics was evaluated by liquid chromatography-tandem mass spectrometry (LC–MS/MS) in those with IPD, dementia with Lewy bodies (DLB), multiple system atrophy (MSA), AD, and progressive supranuclear palsy (PSP) and CNs. Results The results showed that (1) plasma sphingosine-1-phosphate (S1P) was significantly lower in all neurodegenerative disease groups (IPD, DLB, MSA, AD, and PSP) than in the CN group. (2) Plasma monohexylceramide (MonCer) and lactosylceramide (LacCer) were significantly higher in all neurodegenerative disease groups (IPD, DLB, MSA, AD, and PSP) than in the CN group. (3) Plasma MonCer levels were significantly positively correlated with plasma LacCer levels in all enrolled groups. Conclusion S1P, Glucosylceramide (GlcCer), the main component of MonCer, and LacCer are sphingolipids that are biosynthesized from ceramide. Recent studies have suggested that elevated GlcCer and decreased S1P levels in neurons are related to neuronal cell death and that elevated LacCer levels induce neurodegeneration by neuroinflammation. In the present study, we found decreased plasma S1P levels and elevated plasma MonCer and LacCer levels in those with neurodegenerative diseases, which is a new finding indicating the importance of abnormal sphingolipid metabolism in neurodegeneration.
Materialart:
Online-Ressource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0279315
DOI:
10.1371/journal.pone.0279315.g001
DOI:
10.1371/journal.pone.0279315.g002
DOI:
10.1371/journal.pone.0279315.g003
DOI:
10.1371/journal.pone.0279315.g004
DOI:
10.1371/journal.pone.0279315.g005
DOI:
10.1371/journal.pone.0279315.t001
DOI:
10.1371/journal.pone.0279315.t002
DOI:
10.1371/journal.pone.0279315.t003
DOI:
10.1371/journal.pone.0279315.s001
DOI:
10.1371/journal.pone.0279315.s002
DOI:
10.1371/journal.pone.0279315.s003
DOI:
10.1371/journal.pone.0279315.s004
DOI:
10.1371/journal.pone.0279315.s005
DOI:
10.1371/journal.pone.0279315.s006
DOI:
10.1371/journal.pone.0279315.r001
DOI:
10.1371/journal.pone.0279315.r002
DOI:
10.1371/journal.pone.0279315.r003
DOI:
10.1371/journal.pone.0279315.r004
DOI:
10.1371/journal.pone.0279315.r005
DOI:
10.1371/journal.pone.0279315.r006
DOI:
10.1371/journal.pone.0279315.r007
DOI:
10.1371/journal.pone.0279315.r008
Sprache:
Englisch
Verlag:
Public Library of Science (PLoS)
Publikationsdatum:
2022
ZDB Id:
2267670-3
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