In:
PLOS ONE, Public Library of Science (PLoS), Vol. 18, No. 5 ( 2023-5-3), p. e0285127-
Abstract:
Little has been known about the intrableb structures associated with bleb function after trabeculectomy with amniotic membrane transplantation (AMT). The aim of this study is to analyze the characteristics of intrableb structures using anterior segment optical coherence tomography (AS-OCT) after trabeculectomy with AMT. Methods A total of 68 eyes of 68 patients with primary open-angle glaucoma who underwent trabeculectomy with AMT were included. Surgical success was defined as intraocular pressure (IOP) ≤ 18 mmHg and IOP reduction of ≥ 20% without medication on AS-OCT examination. Intrableb parameters, including bleb height, bleb wall thickness, striping layer thickness, bleb wall reflectivity, fluid-filled space score, fluid-filled space height, and microcyst formation were evaluated using AS-OCT. Logistic regression analysis was performed to determine factors associated with IOP control. Results Of the 68 eyes, 56 eyes were assigned to the success group and 12 eyes to the failure group. In the success group, bleb height ( P = 0.009), bleb wall thickness ( P = 0.001), striping layer thickness ( P = 0.001), fluid-filled space score ( P = 0.001), and frequency of microcyst formation ( P = 0.001) were greater than those in the failure group. Bleb wall reflectivity was higher in the failure group than in the success group ( P 〈 0.001). In the univariate logistic regression analysis, previous cataract surgery was significantly associated with surgical failure (odds ratio = 5.769, P = 0.032). Conclusion A posteriorly extending fluid-filled space, tall bleb with low reflectivity, and thick striping layer were characteristics of successful filtering blebs after trabeculectomy with AMT.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0285127
DOI:
10.1371/journal.pone.0285127.g001
DOI:
10.1371/journal.pone.0285127.g002
DOI:
10.1371/journal.pone.0285127.g003
DOI:
10.1371/journal.pone.0285127.g004
DOI:
10.1371/journal.pone.0285127.g005
DOI:
10.1371/journal.pone.0285127.t001
DOI:
10.1371/journal.pone.0285127.t002
DOI:
10.1371/journal.pone.0285127.t003
DOI:
10.1371/journal.pone.0285127.s001
DOI:
10.1371/journal.pone.0285127.s002
DOI:
10.1371/journal.pone.0285127.s003
DOI:
10.1371/journal.pone.0285127.s004
DOI:
10.1371/journal.pone.0285127.r001
DOI:
10.1371/journal.pone.0285127.r002
DOI:
10.1371/journal.pone.0285127.r003
DOI:
10.1371/journal.pone.0285127.r004
DOI:
10.1371/journal.pone.0285127.r005
DOI:
10.1371/journal.pone.0285127.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2267670-3
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