In:
PLOS Biology, Public Library of Science (PLoS), Vol. 19, No. 9 ( 2021-9-9), p. e3000923-
Abstract:
Current approaches to high-field functional MRI (fMRI) provide 2 means to map hemodynamics at the level of single vessels in the brain. One is through changes in deoxyhemoglobin in venules, i.e., blood oxygenation level–dependent (BOLD) fMRI, while the second is through changes in arteriole diameter, i.e., cerebral blood volume (CBV) fMRI. Here, we introduce cerebral blood flow–related velocity-based fMRI, denoted CBFv-fMRI, which uses high-resolution phase contrast (PC) MRI to form velocity measurements of flow. We use CBFv-fMRI in measure changes in blood velocity in single penetrating microvessels across rat parietal cortex. In contrast to the venule-dominated BOLD and arteriole-dominated CBV fMRI signals, CBFv-fMRI is comparable from both arterioles and venules. A single fMRI platform is used to map changes in blood pO 2 (BOLD), volume (CBV), and velocity (CBFv). This combined high-resolution single-vessel fMRI mapping scheme enables vessel-specific hemodynamic mapping in animal models of normal and diseased states and further has translational potential to map vascular dementia in diseased or injured human brains with ultra–high-field fMRI.
Type of Medium:
Online Resource
ISSN:
1545-7885
DOI:
10.1371/journal.pbio.3000923
DOI:
10.1371/journal.pbio.3000923.g001
DOI:
10.1371/journal.pbio.3000923.g002
DOI:
10.1371/journal.pbio.3000923.g003
DOI:
10.1371/journal.pbio.3000923.s001
DOI:
10.1371/journal.pbio.3000923.s002
DOI:
10.1371/journal.pbio.3000923.s003
DOI:
10.1371/journal.pbio.3000923.s004
DOI:
10.1371/journal.pbio.3000923.s005
DOI:
10.1371/journal.pbio.3000923.s006
DOI:
10.1371/journal.pbio.3000923.s007
DOI:
10.1371/journal.pbio.3000923.s008
DOI:
10.1371/journal.pbio.3000923.s009
DOI:
10.1371/journal.pbio.3000923.s010
DOI:
10.1371/journal.pbio.3000923.s011
DOI:
10.1371/journal.pbio.3000923.s012
DOI:
10.1371/journal.pbio.3000923.s013
DOI:
10.1371/journal.pbio.3000923.s014
DOI:
10.1371/journal.pbio.3000923.r001
DOI:
10.1371/journal.pbio.3000923.r002
DOI:
10.1371/journal.pbio.3000923.r003
DOI:
10.1371/journal.pbio.3000923.r004
DOI:
10.1371/journal.pbio.3000923.r005
DOI:
10.1371/journal.pbio.3000923.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2126773-X
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