In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 7 ( 2022-7-21), p. e0271213-
Abstract:
This review sought to address an evidence gap and lay a foundation for future Chronic Traumatic Encephalopathy (CTE) management studies by evaluating and appraising the literature which reports the effect that active rehabilitation has on other tauopathies, a group of conditions with hyperphosphorylation and aggregation of tau protein that can lead to neurodegeneration. Design Umbrella review. Data source Meta-analyses and systematic reviews were identified using CINAHL, Medline, Cochrane, Web of Science, PubMed, and SPORTDiscus. Eligibility Systematic review or meta-analyses that examine the effect active rehabilitation has on outcome measures of symptoms associated with CTE. Studies with men and women diagnosed with Alzheimer’s disease, Parkinson’s disease, Lewy Body dementia, Frontotemporal degeneration/dementia or Corticobasal degeneration. All types of active rehabilitation were included. Control group was usual care, no intervention, or light-intensity physical activity. Results Twelve reviews were included. A large pooled standardized mean difference (SMD) was observed for balance (SMD = 0.88, P 〈 0.001) and motor function (SMD = 0.83, P 〈 0.001). A moderate pooled SMD was observed for cognitive function (SMD = 0.66, P 〈 0.116). A small pooled SMD was observed for mobility (SMD = 0.45, P = 0.002). A trivial pooled SMD was observed for gait speed/velocity (SMD = 0.11, P = 0.372). No findings for mood/behavioral symptoms. All pooled effects demonstrated substantial to considerable heterogeneity (74.3% to 91.9%, P 〈 0.001). Conclusions A positive effect of active rehabilitation was observed in patients with tau pathologies suffering from motor, vestibular and cognitive impairments supporting the use of active rehabilitation for CTE management; however, the findings need to be considered with caution given the limited research in some of the tau pathologies, large between-study heterogeneity and wide 95% prediction intervals.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0271213
DOI:
10.1371/journal.pone.0271213.g001
DOI:
10.1371/journal.pone.0271213.g002
DOI:
10.1371/journal.pone.0271213.g003
DOI:
10.1371/journal.pone.0271213.g004
DOI:
10.1371/journal.pone.0271213.g005
DOI:
10.1371/journal.pone.0271213.t001
DOI:
10.1371/journal.pone.0271213.t002
DOI:
10.1371/journal.pone.0271213.s001
DOI:
10.1371/journal.pone.0271213.s002
DOI:
10.1371/journal.pone.0271213.s003
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
Permalink