In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 3 ( 2022-3-31), p. e0265965-
Abstract:
Routine mammography screening is currently the standard tool for finding cancers at an early stage, when treatment is most successful. Current breast screening programmes are one-size-fits-all which all women above a certain age threshold are encouraged to participate. However, breast cancer risk varies by individual. The BREAst screening Tailored for HEr (BREATHE) study aims to assess acceptability of a comprehensive risk-based personalised breast screening in Singapore. Advancing beyond the current age-based screening paradigm, BREATHE integrates both genetic and non-genetic breast cancer risk prediction tools to personalise screening recommendations. BREATHE is a cohort study targeting to recruit ~3,500 women. The first recruitment visit will include questionnaires and a buccal cheek swab. After receiving a tailored breast cancer risk report, participants will attend an in-person risk review, followed by a final session assessing the acceptability of our risk stratification programme. Risk prediction is based on: a) Gail model (non-genetic), b) mammographic density and recall, c) BOADICEA predictions (breast cancer predisposition genes), and d) breast cancer polygenic risk score. For national implementation of personalised risk-based breast screening, exploration of the acceptability within the target populace is critical, in addition to validated predication tools. To our knowledge, this is the first study to implement a comprehensive risk-based mammography screening programme in Asia. The BREATHE study will provide essential data for policy implementation which will transform the health system to deliver a better health and healthcare outcomes.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0265965
DOI:
10.1371/journal.pone.0265965.g001
DOI:
10.1371/journal.pone.0265965.t001
DOI:
10.1371/journal.pone.0265965.t002
DOI:
10.1371/journal.pone.0265965.t003
DOI:
10.1371/journal.pone.0265965.s001
DOI:
10.1371/journal.pone.0265965.s002
DOI:
10.1371/journal.pone.0265965.s003
DOI:
10.1371/journal.pone.0265965.s004
DOI:
10.1371/journal.pone.0265965.s005
DOI:
10.1371/journal.pone.0265965.s006
DOI:
10.1371/journal.pone.0265965.s007
DOI:
10.1371/journal.pone.0265965.s008
DOI:
10.1371/journal.pone.0265965.r001
DOI:
10.1371/journal.pone.0265965.r002
DOI:
10.1371/journal.pone.0265965.r003
DOI:
10.1371/journal.pone.0265965.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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