In:
PLOS Computational Biology, Public Library of Science (PLoS), Vol. 19, No. 2 ( 2023-2-27), p. e1010914-
Abstract:
Environmentally induced or epigenetic-related beta-cell dysfunction and insulin resistance play a critical role in the progression to diabetes. We developed a mathematical modeling framework capable of studying the progression to diabetes incorporating various diabetogenic factors. Considering the heightened risk of beta-cell defects induced by obesity, we focused on the obesity-diabetes model to further investigate the influence of obesity on beta-cell function and glucose regulation. The model characterizes individualized glucose and insulin dynamics over the span of a lifetime. We then fit the model to the longitudinal data of the Pima Indian population, which captures both the fluctuations and long-term trends of glucose levels. As predicted, controlling or eradicating the obesity-related factor can alleviate, postpone, or even reverse diabetes. Furthermore, our results reveal that distinct abnormalities of beta-cell function and levels of insulin resistance among individuals contribute to different risks of diabetes. This study may encourage precise interventions to prevent diabetes and facilitate individualized patient treatment.
Type of Medium:
Online Resource
ISSN:
1553-7358
DOI:
10.1371/journal.pcbi.1010914
DOI:
10.1371/journal.pcbi.1010914.g001
DOI:
10.1371/journal.pcbi.1010914.g002
DOI:
10.1371/journal.pcbi.1010914.g003
DOI:
10.1371/journal.pcbi.1010914.g004
DOI:
10.1371/journal.pcbi.1010914.g005
DOI:
10.1371/journal.pcbi.1010914.g006
DOI:
10.1371/journal.pcbi.1010914.g007
DOI:
10.1371/journal.pcbi.1010914.g008
DOI:
10.1371/journal.pcbi.1010914.g009
DOI:
10.1371/journal.pcbi.1010914.g010
DOI:
10.1371/journal.pcbi.1010914.t001
DOI:
10.1371/journal.pcbi.1010914.t002
DOI:
10.1371/journal.pcbi.1010914.s001
DOI:
10.1371/journal.pcbi.1010914.s002
DOI:
10.1371/journal.pcbi.1010914.s003
DOI:
10.1371/journal.pcbi.1010914.s004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2193340-6
Permalink