In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 3 ( 2021-3-3), p. e0247251-
Abstract:
In the context of COVID-19 pandemic, we aimed to analyze the epidemiology, clinical characteristics, risk factors for mortality and impact of COVID-19 on outcomes of solid organ transplant (SOT) recipients compared to a cohort of non transplant patients, evaluating if transplantation could be considered a risk factor for mortality. From March to May 2020, 261 hospitalized patients with COVID-19 pneumonia were evaluated, including 41 SOT recipients. Of these, thirty-two were kidney recipients, 4 liver, 3 heart and 2 combined kidney-liver transplants. Median time from transplantation to COVID-19 diagnosis was 6 years. Thirteen SOT recipients (32%) required Intensive Care Unit (ICU) admission and 5 patients died (12%). Using a propensity score match analysis, we found no significant differences between SOT recipients and non-transplant patients. Older age (OR 1.142; 95% [CI 1.08–1.197]) higher levels of C-reactive protein (OR 3.068 ; 95% [CI 1.22–7.71]) and levels of serum creatinine on admission (OR 3.048 95% [CI 1.22–7.57] ) were associated with higher mortality. The clinical outcomes of SARS-CoV-2 infection in our cohort of SOT recipients appear to be similar to that observed in the non-transplant population. Older age, higher levels of C-reactive protein and serum creatinine were associated with higher mortality, whereas SOT was not associated with worse outcomes.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0247251
DOI:
10.1371/journal.pone.0247251.g001
DOI:
10.1371/journal.pone.0247251.t001
DOI:
10.1371/journal.pone.0247251.t002
DOI:
10.1371/journal.pone.0247251.t003
DOI:
10.1371/journal.pone.0247251.t004
DOI:
10.1371/journal.pone.0247251.t005
DOI:
10.1371/journal.pone.0247251.s001
DOI:
10.1371/journal.pone.0247251.s002
DOI:
10.1371/journal.pone.0247251.s003
DOI:
10.1371/journal.pone.0247251.s004
DOI:
10.1371/journal.pone.0247251.r001
DOI:
10.1371/journal.pone.0247251.r002
DOI:
10.1371/journal.pone.0247251.r003
DOI:
10.1371/journal.pone.0247251.r004
DOI:
10.1371/journal.pone.0247251.r005
DOI:
10.1371/journal.pone.0247251.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3
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