In:
PLOS Biology, Public Library of Science (PLoS), Vol. 20, No. 2 ( 2022-2-3), p. e3001493-
Abstract:
Hearing one’s own voice is critical for fluent speech production as it allows for the detection and correction of vocalization errors in real time. This behavior known as the auditory feedback control of speech is impaired in various neurological disorders ranging from stuttering to aphasia; however, the underlying neural mechanisms are still poorly understood. Computational models of speech motor control suggest that, during speech production, the brain uses an efference copy of the motor command to generate an internal estimate of the speech output. When actual feedback differs from this internal estimate, an error signal is generated to correct the internal estimate and update necessary motor commands to produce intended speech. We were able to localize the auditory error signal using electrocorticographic recordings from neurosurgical participants during a delayed auditory feedback (DAF) paradigm. In this task, participants hear their voice with a time delay as they produced words and sentences (similar to an echo on a conference call), which is well known to disrupt fluency by causing slow and stutter-like speech in humans. We observed a significant response enhancement in auditory cortex that scaled with the duration of feedback delay, indicating an auditory speech error signal. Immediately following auditory cortex, dorsal precentral gyrus (dPreCG), a region that has not been implicated in auditory feedback processing before, exhibited a markedly similar response enhancement, suggesting a tight coupling between the 2 regions. Critically, response enhancement in dPreCG occurred only during articulation of long utterances due to a continuous mismatch between produced speech and reafferent feedback. These results suggest that dPreCG plays an essential role in processing auditory error signals during speech production to maintain fluency.
Type of Medium:
Online Resource
ISSN:
1545-7885
DOI:
10.1371/journal.pbio.3001493
DOI:
10.1371/journal.pbio.3001493.g001
DOI:
10.1371/journal.pbio.3001493.g002
DOI:
10.1371/journal.pbio.3001493.g003
DOI:
10.1371/journal.pbio.3001493.g004
DOI:
10.1371/journal.pbio.3001493.g005
DOI:
10.1371/journal.pbio.3001493.g006
DOI:
10.1371/journal.pbio.3001493.g007
DOI:
10.1371/journal.pbio.3001493.g008
DOI:
10.1371/journal.pbio.3001493.s001
DOI:
10.1371/journal.pbio.3001493.s002
DOI:
10.1371/journal.pbio.3001493.s003
DOI:
10.1371/journal.pbio.3001493.s004
DOI:
10.1371/journal.pbio.3001493.s005
DOI:
10.1371/journal.pbio.3001493.s006
DOI:
10.1371/journal.pbio.3001493.s007
DOI:
10.1371/journal.pbio.3001493.s008
DOI:
10.1371/journal.pbio.3001493.s009
DOI:
10.1371/journal.pbio.3001493.s010
DOI:
10.1371/journal.pbio.3001493.s011
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10.1371/journal.pbio.3001493.s012
DOI:
10.1371/journal.pbio.3001493.s013
DOI:
10.1371/journal.pbio.3001493.s014
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10.1371/journal.pbio.3001493.s015
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10.1371/journal.pbio.3001493.s016
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10.1371/journal.pbio.3001493.s017
DOI:
10.1371/journal.pbio.3001493.s018
DOI:
10.1371/journal.pbio.3001493.s019
DOI:
10.1371/journal.pbio.3001493.s020
DOI:
10.1371/journal.pbio.3001493.s021
DOI:
10.1371/journal.pbio.3001493.r001
DOI:
10.1371/journal.pbio.3001493.r002
DOI:
10.1371/journal.pbio.3001493.r003
DOI:
10.1371/journal.pbio.3001493.r004
DOI:
10.1371/journal.pbio.3001493.r005
DOI:
10.1371/journal.pbio.3001493.r006
DOI:
10.1371/journal.pbio.3001493.r007
DOI:
10.1371/journal.pbio.3001493.r008
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2126773-X
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