In:
PLOS ONE, Public Library of Science (PLoS), Vol. 18, No. 7 ( 2023-7-11), p. e0288421-
Abstract:
We investigated whether the feasibility of left ventricular (LV) global longitudinal strain (GLS) in hypertrophic cardiomyopathy (HCM) varies according to the methodology (e.g. endocardial vs. whole myocardial tracking techniques). Methods We retrospectively analyzed 111 consecutive patients with HCM (median age, 58 years; male, 68.5%) who underwent both transthoracic echocardiography (TTE) and cardiac magnetic resonance imaging (apical 29.7%, septal 33.3%, and diffuse or mixed 37.0%). TTE-whole myocardial and TTE-endocardial GLS were measured and compared in terms of association with late gadolinium enhancement (LGE) extent and discrimination performance for extensive LGE ( 〉 15% of the LV myocardium). Results Although TTE-whole myocardial and TTE-endocardial GLS were significantly correlated, absolute TTE-endocardial GLS values (19.3 [16.2–21.9] %) were higher than TTE-whole myocardial GLS values (13.3[10.9–15.6] %, p 〈 0.001). Both TTE-derived GLS parameters were significantly correlated with the LGE extent and independently associated with extensive LGE (odds ratio [OR] 1.30, p = 0.022; and OR 1.24, p = 0.013, respectively). Discrimination performance for extensive LGE was comparable between TTE-whole myocardial and TTE-endocardial GLS (area under the curve [AUC] , 0.747 and 0.754, respectively, p difference = 0.610). However, among patients with higher LV mass index ( 〉 70 g/m 2 ), only TTE-whole myocardial GLS correlated with LGE extent and was independently associated with extensive LGE (OR 1.35, p = 0.042), while TTE-endocardial GLS did not. Additionally, TTE-whole myocardial GLS had better discrimination performance for extensive LGE than TTE-endocardial GLS (AUC, 0.705 and 0.668, respectively, p difference = 0.006). Conclusion TTE-derived GLS using either the endocardial or whole myocardial tracking technique is feasible in patients with HCM. However, in those with severe hypertrophy, TTE-whole myocardial GLS is better than TTE-endocardial GLS.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0288421
DOI:
10.1371/journal.pone.0288421.g001
DOI:
10.1371/journal.pone.0288421.g002
DOI:
10.1371/journal.pone.0288421.g003
DOI:
10.1371/journal.pone.0288421.g004
DOI:
10.1371/journal.pone.0288421.t001
DOI:
10.1371/journal.pone.0288421.t002
DOI:
10.1371/journal.pone.0288421.t003
DOI:
10.1371/journal.pone.0288421.t004
DOI:
10.1371/journal.pone.0288421.s001
DOI:
10.1371/journal.pone.0288421.s002
DOI:
10.1371/journal.pone.0288421.s003
DOI:
10.1371/journal.pone.0288421.s004
DOI:
10.1371/journal.pone.0288421.s005
DOI:
10.1371/journal.pone.0288421.s006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2267670-3
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