In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 3 ( 2022-3-24), p. e0265668-
Abstract:
The incidence and mortality of hepatocellular carcinoma (HCC) have decreased over time in South Korea, where hepatitis B virus (HBV) in endemic. This study investigated the changes in the characteristics and clinical outcomes of HCC patients in Korea. Methods Patients initially diagnosed with HCC and treated at the National Cancer Center, Korea between 2000 and 2015 (n = 4,291) were followed up until February 2017. Differences in patient characteristics and outcomes were compared between chronological cohorts: cohort A (2000–2004, n = 1,157) vs . B (2005–2009, n = 1,678) vs . C (2010–2015, n = 1,456). Results The median age of the patient cohort was 57 years (range, 13–98 years), and male predominance was noted (81.6%). HBV infection was the most common etiology (74.8%). The proportion of patients diagnosed with good liver function and small tumors ( 〈 2 cm) increased significantly over time: 74.6%, 79.9%, and 87.4% for Child–Pugh class A ( p 〈 0.001) and 8.0%, 8.5%, and 12.0% for modified UICC stage I ( p 〈 0.001) in cohorts A, B, and C, respectively. Median overall survival improved significantly over time: 14.4 months (95% confidence interval [CI], 12.0–16.8 months), 22.9 months (95% CI, 20.3–25.5 months), and 53.6 months (95% CI, 45.7–61.5 months) in cohorts A, B, and C, respectively. HBV-related patients showed significantly improved survival (12.7 vs . 20.4 vs . 64.5 months, p 〈 0.001) associated with the use of antiviral treatments (adjusted hazard ratio, 0.72; 95% CI, 0.64–0.80). Conclusions The survival of patients with HCC, especially HBV-related HCC, has improved significantly over time in Korea.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0265668
DOI:
10.1371/journal.pone.0265668.g001
DOI:
10.1371/journal.pone.0265668.g002
DOI:
10.1371/journal.pone.0265668.g003
DOI:
10.1371/journal.pone.0265668.t001
DOI:
10.1371/journal.pone.0265668.t002
DOI:
10.1371/journal.pone.0265668.s001
DOI:
10.1371/journal.pone.0265668.s002
DOI:
10.1371/journal.pone.0265668.s003
DOI:
10.1371/journal.pone.0265668.s004
DOI:
10.1371/journal.pone.0265668.s005
DOI:
10.1371/journal.pone.0265668.s006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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