In:
PLOS Pathogens, Public Library of Science (PLoS), Vol. 17, No. 9 ( 2021-9-16), p. e1009918-
Abstract:
Under RNA virus infection, retinoic acid-inducible gene I (RIG-I) in host cells recognizes viral RNA and activates the expression of type I IFN. To investigate the roles of protein methyltransferases and demethylases in RIG-I antiviral signaling pathway, we screened all the known related enzymes with a siRNA library and identified LSD1 as a positive regulator for RIG-I signaling. Exogenous expression of LSD1 enhances RIG-I signaling activated by virus stimulation, whereas its deficiency restricts it. LSD1 interacts with RIG-I, promotes its K63-linked polyubiquitination and interaction with VISA/MAVS. Interestingly, LSD1 exerts its function in antiviral response not dependent on its demethylase activity but through enhancing the interaction between RIG-I with E3 ligases, especially TRIM25. Furthermore, we provide in vivo evidence that LSD1 increases antiviral gene expression and inhibits viral replication. Taken together, our findings demonstrate that LSD1 is a positive regulator of signaling pathway triggered by RNA-virus through mediating RIG-I polyubiquitination.
Type of Medium:
Online Resource
ISSN:
1553-7374
DOI:
10.1371/journal.ppat.1009918
DOI:
10.1371/journal.ppat.1009918.g001
DOI:
10.1371/journal.ppat.1009918.g002
DOI:
10.1371/journal.ppat.1009918.g003
DOI:
10.1371/journal.ppat.1009918.g004
DOI:
10.1371/journal.ppat.1009918.g005
DOI:
10.1371/journal.ppat.1009918.g006
DOI:
10.1371/journal.ppat.1009918.s001
DOI:
10.1371/journal.ppat.1009918.s002
DOI:
10.1371/journal.ppat.1009918.s003
DOI:
10.1371/journal.ppat.1009918.s004
DOI:
10.1371/journal.ppat.1009918.s005
DOI:
10.1371/journal.ppat.1009918.s006
DOI:
10.1371/journal.ppat.1009918.s007
DOI:
10.1371/journal.ppat.1009918.s008
DOI:
10.1371/journal.ppat.1009918.s009
DOI:
10.1371/journal.ppat.1009918.s010
DOI:
10.1371/journal.ppat.1009918.s011
DOI:
10.1371/journal.ppat.1009918.s012
DOI:
10.1371/journal.ppat.1009918.s013
DOI:
10.1371/journal.ppat.1009918.r001
DOI:
10.1371/journal.ppat.1009918.r002
DOI:
10.1371/journal.ppat.1009918.r003
DOI:
10.1371/journal.ppat.1009918.r004
DOI:
10.1371/journal.ppat.1009918.r005
DOI:
10.1371/journal.ppat.1009918.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2205412-1
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