In:
PLOS ONE, Public Library of Science (PLoS), Vol. 18, No. 9 ( 2023-9-14), p. e0290251-
Abstract:
Angiotensin receptor blockers (ARBs) are considered an alternative to angiotensin-converting enzyme inhibitors (ACEIs) in patients with acute myocardial infarction (AMI), but in the era of extensive use of preventive therapies and percutaneous coronary intervention, this has not been adequately evaluated in Asians. Methods This retrospective cohort study used data from the Taiwan National Health Insurance Research Database. In total, 52,620 patients initially hospitalized due to AMI between 2002 and 2015 were assessed. Results After propensity score matching, 14,993 patients each were assigned to ACEI and ARB groups. Patients who received ARBs had significantly lower all-cause mortality (adjusted hazard ratio [aHR]: 0.82; 95% confidence interval [CI] : 0.75–0.90) and hospitalization for heart failure (aHR: 0.92; 95% CI: 0.85–0.99) compared with those who received ACEIs at 18 month follow-up. No significant difference was observed between the two groups in terms of major adverse cardiovascular events (aHR: 098; 95% CI: 0.90–1.07), cardiovascular death (aHR: 0.82; 95% CI: 0.68–1.00), ischemia stroke (aHR: 0.93; 95% CI: 0.77–1.11), and nonfatal myocardial infarction (aHR: 1.04; 95% CI: 0.93–1.17). ARBs showed benefits in many subgroups in terms of all-cause mortality and cardiovascular death. Conclusions Real-world data demonstrate that ARBs might be associated with lower all-cause mortality and hospitalization for heart failure compared with ACEIs among patients with AMI.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0290251
DOI:
10.1371/journal.pone.0290251.g001
DOI:
10.1371/journal.pone.0290251.g002
DOI:
10.1371/journal.pone.0290251.g003
DOI:
10.1371/journal.pone.0290251.t001
DOI:
10.1371/journal.pone.0290251.t002
DOI:
10.1371/journal.pone.0290251.t003
DOI:
10.1371/journal.pone.0290251.s001
DOI:
10.1371/journal.pone.0290251.s002
DOI:
10.1371/journal.pone.0290251.s003
DOI:
10.1371/journal.pone.0290251.s004
DOI:
10.1371/journal.pone.0290251.s005
DOI:
10.1371/journal.pone.0290251.s006
DOI:
10.1371/journal.pone.0290251.s007
DOI:
10.1371/journal.pone.0290251.r001
DOI:
10.1371/journal.pone.0290251.r002
DOI:
10.1371/journal.pone.0290251.r003
DOI:
10.1371/journal.pone.0290251.r004
DOI:
10.1371/journal.pone.0290251.r005
DOI:
10.1371/journal.pone.0290251.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2267670-3
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