In:
PLOS ONE, Public Library of Science (PLoS), Vol. 19, No. 2 ( 2024-2-29), p. e0299487-
Abstract:
Metabolic dysfunction Associated Steatotic Liver Disease (MASLD) outcomes such as MASH (metabolic dysfunction associated steatohepatitis), fibrosis and cirrhosis are ordinarily determined by resource-intensive and invasive biopsies. We aim to show that routine clinical tests offer sufficient information to predict these endpoints. Methods Using the LITMUS Metacohort derived from the European NAFLD Registry, the largest MASLD dataset in Europe, we create three combinations of features which vary in degree of procurement including a 19-variable feature set that are attained through a routine clinical appointment or blood test. This data was used to train predictive models using supervised machine learning (ML) algorithm XGBoost, alongside missing imputation technique MICE and class balancing algorithm SMOTE. Shapley Additive exPlanations (SHAP) were added to determine relative importance for each clinical variable. Results Analysing nine biopsy-derived MASLD outcomes of cohort size ranging between 5385 and 6673 subjects, we were able to predict individuals at training set AUCs ranging from 0.719-0.994, including classifying individuals who are At-Risk MASH at an AUC = 0.899. Using two further feature combinations of 26-variables and 35-variables, which included composite scores known to be good indicators for MASLD endpoints and advanced specialist tests, we found predictive performance did not sufficiently improve. We are also able to present local and global explanations for each ML model, offering clinicians interpretability without the expense of worsening predictive performance. Conclusions This study developed a series of ML models of accuracy ranging from 71.9—99.4% using only easily extractable and readily available information in predicting MASLD outcomes which are usually determined through highly invasive means.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0299487
DOI:
10.1371/journal.pone.0299487.g001
DOI:
10.1371/journal.pone.0299487.g002
DOI:
10.1371/journal.pone.0299487.g003
DOI:
10.1371/journal.pone.0299487.g004
DOI:
10.1371/journal.pone.0299487.g005
DOI:
10.1371/journal.pone.0299487.t001
DOI:
10.1371/journal.pone.0299487.t002
DOI:
10.1371/journal.pone.0299487.t003
DOI:
10.1371/journal.pone.0299487.s001
DOI:
10.1371/journal.pone.0299487.s002
DOI:
10.1371/journal.pone.0299487.r001
DOI:
10.1371/journal.pone.0299487.r002
DOI:
10.1371/journal.pone.0299487.r003
DOI:
10.1371/journal.pone.0299487.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2024
detail.hit.zdb_id:
2267670-3
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