In:
PLOS ONE, Public Library of Science (PLoS), Vol. 15, No. 11 ( 2020-11-18), p. e0241541-
Abstract:
Understanding the factors associated with disease severity and mortality in Coronavirus disease (COVID-19) is imperative to effectively triage patients. We performed a systematic review to determine the demographic, clinical, laboratory and radiological factors associated with severity and mortality in COVID-19. Methods We searched PubMed, Embase and WHO database for English language articles from inception until May 8, 2020. We included Observational studies with direct comparison of clinical characteristics between a) patients who died and those who survived or b) patients with severe disease and those without severe disease. Data extraction and quality assessment were performed by two authors independently. Results Among 15680 articles from the literature search, 109 articles were included in the analysis. The risk of mortality was higher in patients with increasing age, male gender (RR 1.45, 95%CI 1.23–1.71), dyspnea (RR 2.55, 95%CI 1.88–2.46), diabetes (RR 1.59, 95%CI 1.41–1.78), hypertension (RR 1.90, 95%CI 1.69–2.15). Congestive heart failure (OR 4.76, 95%CI 1.34–16.97), hilar lymphadenopathy (OR 8.34, 95%CI 2.57–27.08), bilateral lung involvement (OR 4.86, 95%CI 3.19–7.39) and reticular pattern (OR 5.54, 95%CI 1.24–24.67) were associated with severe disease. Clinically relevant cut-offs for leukocytosis( 〉 10.0 x10 9 /L), lymphopenia( 〈 1.1 x10 9 /L), elevated C-reactive protein( 〉 100mg/L), LDH( 〉 250U/L) and D-dimer( 〉 1mg/L) had higher odds of severe disease and greater risk of mortality. Conclusion Knowledge of the factors associated of disease severity and mortality identified in our study may assist in clinical decision-making and critical-care resource allocation for patients with COVID-19.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0241541
DOI:
10.1371/journal.pone.0241541.g001
DOI:
10.1371/journal.pone.0241541.g002
DOI:
10.1371/journal.pone.0241541.g003
DOI:
10.1371/journal.pone.0241541.g004
DOI:
10.1371/journal.pone.0241541.g005
DOI:
10.1371/journal.pone.0241541.t001
DOI:
10.1371/journal.pone.0241541.t002
DOI:
10.1371/journal.pone.0241541.t003
DOI:
10.1371/journal.pone.0241541.t004
DOI:
10.1371/journal.pone.0241541.s001
DOI:
10.1371/journal.pone.0241541.s002
DOI:
10.1371/journal.pone.0241541.s003
DOI:
10.1371/journal.pone.0241541.s004
DOI:
10.1371/journal.pone.0241541.r001
DOI:
10.1371/journal.pone.0241541.r002
DOI:
10.1371/journal.pone.0241541.r003
DOI:
10.1371/journal.pone.0241541.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2020
detail.hit.zdb_id:
2267670-3
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