In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 1 ( 2021-1-14), p. e0245434-
Abstract:
The single-breath diffusing capacity of the lung for carbon monoxide ( D LCO ) interpretation needs the comparison of measured values to reference values. In 2017, the Global Lung Function Initiative published new reference values (GLI-2017) for D LCO , alveolar volume ( V A ) and transfer coefficient of the lung for carbon monoxide ( K CO ). We aimed to assess the applicability of GLI-2017 reference values for D LCO on a large population by comparing them to the European Community of Steel and Coal equations of 1993 (ECSC-93) widely used. Methods In this retrospective study, spirometric indices, total lung capacity, D LCO , V A and K CO were measured in adults classified in 5 groups (controls, asthma, chronic bronchitis, cystic fibrosis, and interstitial lung diseases (ILD)). Statistical analysis comparing the 2 equations sets were stratified by sex. Results 4180 tests were included. GLI-2017 z-scores of the 3 D LCO indices of the controls (n = 150) are nearer to 0 (expected value in a normal population) than ECSC-93 z-scores. All groups combined, in both genders, D LCO GLI-2017 z-scores and %predicted are significantly higher than ECSC z-scores and %predicted. In the ILD group, differences between the 2 equation sets depend on the D LCO impairment severity: GLI-2017 z-scores are higher than ECSC z-scores in patients with no or “mild” decrease in D LCO , but are lower in “moderate” or “severe” decrease. Conclusion GLI-2017 reference values for D LCO are more suitable to our population and influence the diagnostic criteria and severity definition of several lung diseases.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0245434
DOI:
10.1371/journal.pone.0245434.g001
DOI:
10.1371/journal.pone.0245434.g002
DOI:
10.1371/journal.pone.0245434.t001
DOI:
10.1371/journal.pone.0245434.t002
DOI:
10.1371/journal.pone.0245434.t003
DOI:
10.1371/journal.pone.0245434.t004
DOI:
10.1371/journal.pone.0245434.s001
DOI:
10.1371/journal.pone.0245434.s002
DOI:
10.1371/journal.pone.0245434.s003
DOI:
10.1371/journal.pone.0245434.s004
DOI:
10.1371/journal.pone.0245434.s005
DOI:
10.1371/journal.pone.0245434.s006
DOI:
10.1371/journal.pone.0245434.r001
DOI:
10.1371/journal.pone.0245434.r002
DOI:
10.1371/journal.pone.0245434.r003
DOI:
10.1371/journal.pone.0245434.r004
DOI:
10.1371/journal.pone.0245434.r005
DOI:
10.1371/journal.pone.0245434.r006
DOI:
10.1371/journal.pone.0245434.r007
DOI:
10.1371/journal.pone.0245434.r008
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3
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