In:
Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 98, No. 3 ( 2001-01-30), p. 1024-1029
Abstract:
Endostatin, a fragment of collagen XVIII, is a potent antagonist of
angiogenesis and inhibitor of tumor growth in mouse models. At present, the mechanism of action of endostatin is unknown. We show here that
recombinantly produced human endostatin interacts with α 5 - and α v -integrins on the surface of
human endothelial cells. We further demonstrate that the endostatin–integrin interaction is of functional significance in vitro , as we found that immobilized endostatin
supports endothelial cell survival and migration in an integrin-dependent manner. Soluble endostatin in turn inhibits
integrin-dependent endothelial cell functions, such as cell migration. Taken together, these results implicate integrins as potential targets
for endostatin function and support the importance of integrins in endothelial cell biology and angiogenesis.
Type of Medium:
Online Resource
ISSN:
0027-8424
,
1091-6490
DOI:
10.1073/pnas.98.3.1024
Language:
English
Publisher:
Proceedings of the National Academy of Sciences
Publication Date:
2001
detail.hit.zdb_id:
209104-5
detail.hit.zdb_id:
1461794-8
SSG:
11
SSG:
12
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