In:
Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 83, No. 12 ( 1986-06), p. 4194-4198
Kurzfassung:
A topographic gradient of TOP molecules in retina can be used to identify neuron position. Antibody to TOP from hybridoma cells that were injected into in vivo embryo eyes diffused into the retina and bound in a topographic gradient of [antibody.TOP] ([Ab.TOP] ) complexes. Synapse formation in retina was inhibited in the presence of anti-TOP antibody. This suggests that TOP is involved in synapse formation and that recognition of position by neurons is necessary for normal synapse formation.
Materialart:
Online-Ressource
ISSN:
0027-8424
,
1091-6490
DOI:
10.1073/pnas.83.12.4194
Sprache:
Englisch
Verlag:
Proceedings of the National Academy of Sciences
Publikationsdatum:
1986
ZDB Id:
209104-5
ZDB Id:
1461794-8
SSG:
11
SSG:
12
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