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  • Portland Press Ltd.  (2)
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  • Portland Press Ltd.  (2)
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  • 1
    Online Resource
    Online Resource
    Translational regulation of Chk1 expression by eIF3a via interaction with the RNA-binding protein HuR
    Portland Press Ltd. ; 2020
    In:  Biochemical Journal Vol. 477, No. 10 ( 2020-05-29), p. 1939-1950
    Details
    In: Biochemical Journal, Portland Press Ltd., Vol. 477, No. 10 ( 2020-05-29), p. 1939-1950
    Abstract: eIF3a is a putative subunit of the eukaryotic translation initiation factor 3 complex. Accumulating evidence suggests that eIF3a may have a translational regulatory function by suppressing translation of a subset of mRNAs while accelerating that of other mRNAs. Albeit the suppression of mRNA translation may derive from eIF3a binding to the 5′-UTRs of target mRNAs, how eIF3a may accelerate mRNA translation remains unknown. In this study, we show that eIF3a up-regulates translation of Chk1 but not Chk2 mRNA by interacting with HuR, which binds directly to the 3′-UTR of Chk1 mRNA. The interaction between eIF3a and HuR occurs at the 10-amino-acid repeat domain of eIF3a and the RNA recognition motif domain of HuR. This interaction may effectively circularize Chk1 mRNA to form an end-to-end complex that has recently been suggested to accelerate mRNA translation. Together with previous findings, we conclude that eIF3a may regulate mRNA translation by directly binding to the 5′-UTR to suppress or by interacting with RNA-binding proteins at 3′-UTRs to accelerate mRNA translation.
    Type of Medium: Online Resource
    ISSN: 0264-6021 , 1470-8728
    URL: Article
    DOI: 10.1042/BCJ20200025
    RVK:
    WA 15000
    Language: English
    Publisher: Portland Press Ltd.
    Publication Date: 2020
    detail.hit.zdb_id: 1473095-9
    SSG: 12
    Location Call Number Limitation Availability
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Translational control gone awry: a new mechanism of tumorigenesis and novel targets of cancer treatments
    Portland Press Ltd. ; 2011
    In:  Bioscience Reports Vol. 31, No. 1 ( 2011-02-01), p. 1-15
    Details
    In: Bioscience Reports, Portland Press Ltd., Vol. 31, No. 1 ( 2011-02-01), p. 1-15
    Abstract: Translational control is one of primary regulation mechanisms of gene expression. Eukaryotic translational control mainly occurs at the initiation step, the speed-limiting step, which involves more than ten translation initiation factors [eIFs (eukaryotic initiation factors)]. Changing the level or function of these eIFs results in abnormal translation of specific mRNAs and consequently abnormal growth of cells that leads to human diseases, including cancer. Accumulating evidence from recent studies showed that the expression of many eIFs was associated with malignant transformation, cancer prognosis, as well as gene expression regulation. In the present paper, we perform a critical review of recent advances in understanding the role and mechanism of eIF action in translational control and cancer as well as the possibility of targeting eIFs for therapeutic development.
    Type of Medium: Online Resource
    ISSN: 0144-8463 , 1573-4935
    URL: Article
    DOI: 10.1042/BSR20100077
    Language: English
    Publisher: Portland Press Ltd.
    Publication Date: 2011
    detail.hit.zdb_id: 2014993-1
    SSG: 12
    Location Call Number Limitation Availability
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    Online Resource
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