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  • Oxford University Press (OUP)  (21)
  • 1
    In: Database, Oxford University Press (OUP), Vol. 2019 ( 2019-01-01)
    Abstract: Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency–Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.
    Type of Medium: Online Resource
    ISSN: 1758-0463
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2019
    detail.hit.zdb_id: 2496706-3
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  • 2
    In: Postgraduate Medical Journal, Oxford University Press (OUP), Vol. 96, No. 1142 ( 2020-12-01), p. 742-746
    Abstract: We are currently faced with an increasing burden of cardiovascular disease in China and the inadequacy of the application of guidelines in clinical practice. In the past decade, China has been strengthening the healthcare system, but it still lacked a national performance measurement system and an appropriate quality improvement strategy. Therefore, in order to improve the implementation of guideline recommendations in clinical practice, China has learnt from the successful experience of Get With The Guidelines project in 2014. Under the guidance of the Medical and Health Hospital of the National Health and Family Planning Commission, the Chinese Society of Cardiology and the American Heart Association jointly launched the Improving Care for Cardiovascular Disease in China (CCC) project. The project team provided an analysis report on the completion of key medical quality evaluation indicators of each hospital every month, supplied guidance through education, training, experience exchange and on-site investigation for problems, and certified hospitals with outstanding performance and obvious progress. The circle pattern, including evaluation, training, improvement and re-evaluation, will boost the guidelines compliance on clinical practice in China and improve the quality of medical services. Methods This study was conducted in a centre of the Third Xiangya Hospital of Central South University. It included patients with ACS from December 2009 to December 2011 (n=225), patients with ACS in the Improving Care for Cardiovascular Disease in China–Acute Coronary Syndrome project coming from the Third Xiangya Hospital of Central South University (n=665), 12 hospitals in Hunan Province (n=4333) and 150 hospitals in China (n=63 641) from November 2014 to April 2017. It assessed the situation of drug therapy, hospitalisation day, mortality during hospitalisation, median of door-to-needle (D-to-N) time and median of door-to-balloon (D-to-B) time of patients with ST-segment elevation myocardial infarction (STEMI), the proportion of D-to-N within 30 min and D-to-B within 90 min, and the proportion of reperfusion therapy. Patients with ACS from the centre from November 2014 to April 2017 were divided into five groups (every 6 months as a group according to time). The study observed change trends in all the above-mentioned indexes. Results Compared with before participating in the CCC project, there were increases after participating in the CCC project in the drug usage rates of aspirin, P2Y12 inhibitor (clopidogrel or ticagrelor), β-blocker, statin and angiotensin converting enzyme inhibitor (ACEI)/angiotensin-receptor blocker (ARB). Hospitalisation day and mortality during hospitalisation were shortened. D-to-N and D-to-B times of patients with STEMI were shorter. Compared with Hunan Province and China, the drug usage rates were higher; hospitalisation day and D-to-N time were shorter; D-to-B time was longer; and the proportion of reperfusion therapy was higher. The trend of drug usage rates was on the rise. There was no significant change in the hospitalisation day and D-to-N and D-to-B times. The mortality during hospitalisation showed a downward trend. The proportion of D-to-N within 90 min and reperfusion therapy showed upward trends. Conclusion Quality of care for patients with ACS improved over time in the CCC project, including taking medicine following the guidelines, increased use of reperfusion therapy and faster time to treatment. Although overall mortality has improved, we also should attach importance to high-risk patients. The influence of the CCC project, which is based on guidelines on prognosis of ACS in the centre, presents an important clinical implication that it is necessary to enhance adherence to the guidelines in the treatment of ACS.
    Type of Medium: Online Resource
    ISSN: 0032-5473 , 1469-0756
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2020
    detail.hit.zdb_id: 2009568-5
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  • 3
    Online Resource
    Online Resource
    Oxford University Press (OUP) ; 2021
    In:  Food Quality and Safety Vol. 5 ( 2021-01-01)
    In: Food Quality and Safety, Oxford University Press (OUP), Vol. 5 ( 2021-01-01)
    Abstract: Fermented goji wine as a functional wine is made from yeast fermentation. To our knowledge, fermented goji wine still has a problem with insufficient characteristic aroma. Research has shown that some isoprene compounds with characteristic aromas may improve the aroma of goji wine. Therefore, the present study aimed to investigate the mechanism of isoprene compound production by carotenoid degradation during the fermentation of goji wine. It was found that C1–C6, C5–C6, C6–C7, C7–C8, C8–C9 and C9–C10 were the most easily degraded sites in carotenoids under seven different pretreatment conditions (mechanical treatment, pectinase treatment, adjustment of pH, autoclave treatment, SO2 treatment, oxidation treatment and light treatment). Meanwhile, breaking different sites, different aroma contributions such as woody, rose, fruity and grassy aromas were found. Single-factor simulation experiments of goji wine during the fermentation showed that the metabolites in the fermentation process caused the degradation of carotenoids and most were volatile aroma compounds. These results may help improve the brewing process to enhance the aroma of goji wine.
    Type of Medium: Online Resource
    ISSN: 2399-1399 , 2399-1402
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2021
    detail.hit.zdb_id: 2899899-6
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  • 4
    In: Journal of Experimental Botany, Oxford University Press (OUP), Vol. 69, No. 5 ( 2018-02-23), p. 1125-1134
    Type of Medium: Online Resource
    ISSN: 0022-0957 , 1460-2431
    RVK:
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2018
    detail.hit.zdb_id: 1466717-4
    SSG: 12
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  • 5
    Online Resource
    Online Resource
    Oxford University Press (OUP) ; 2018
    In:  Journal of Industrial Microbiology and Biotechnology Vol. 45, No. 5 ( 2018-05-01), p. 313-327
    In: Journal of Industrial Microbiology and Biotechnology, Oxford University Press (OUP), Vol. 45, No. 5 ( 2018-05-01), p. 313-327
    Abstract: NAD and NADP, a pivotal class of cofactors, which function as essential electron donors or acceptors in all biological organisms, drive considerable catabolic and anabolic reactions. Furthermore, they play critical roles in maintaining intracellular redox homeostasis. However, many metabolic engineering efforts in industrial microorganisms towards modification or introduction of metabolic pathways, especially those involving consumption, generation or transformation of NAD/NADP, often induce fluctuations in redox state, which dramatically impede cellular metabolism, resulting in decreased growth performance and biosynthetic capacity. Here, we comprehensively review the cofactor engineering strategies for solving the problematic redox imbalance in metabolism modification, as well as their features, suitabilities and recent applications. Some representative examples of in vitro biocatalysis are also described. In addition, we briefly discuss how tools and methods from the field of synthetic biology can be applied for cofactor engineering. Finally, future directions and challenges for development of cofactor redox engineering are presented.
    Type of Medium: Online Resource
    ISSN: 1476-5535 , 1367-5435
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2018
    detail.hit.zdb_id: 1482484-X
    SSG: 12
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  • 6
    In: Cerebral Cortex, Oxford University Press (OUP), Vol. 31, No. 10 ( 2021-08-26), p. 4865-4865
    Type of Medium: Online Resource
    ISSN: 1047-3211 , 1460-2199
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2021
    detail.hit.zdb_id: 1483485-6
    SSG: 12
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  • 7
    In: Clinical Infectious Diseases, Oxford University Press (OUP), Vol. 76, No. 3 ( 2023-02-08), p. e1140-e1149
    Abstract: To provide useful insights into measles elimination progress in China, measles surveillance data were reviewed, and the transmission patterns of measles viruses circulating in China during 1993–2021 were analyzed. Methods Measles incidence data from the National Notifiable Disease Reporting System of the China Center for Disease Control and Prevention were analyzed. A total of 17 570 strains were obtained from 30 of 31 provinces in mainland China during 1993–2021. The recommended genotyping window was amplified. Genotyping analysis was conducted for comparison with the reference strains. Phylogenetic analyses were performed to identify genetic relationships among different lineages within the genotypes. Results With high coverage of routine immunization and intensive supplementary immunization activities, measles incidence has shown a downward trend since 1993, despite 2 resurgences, reaching a historic low level in 2020–2021 (average 0.5 per million). During 1993–2021, 9 genotypes including domestic genotype H1; imported genotypes B3, D4, D8, D9, D11, G3, and H2; and vaccine-associated genotype A were identified. Among them, the genotype H1 strain circulated endemically in China for more than 25 years; the last strain was detected in Yunnan Province in September 2019. Multiple imported genotypes have been identified since 2009 showing different transmission patterns. Since April 2020, no imported strains have been detected, while vaccine-associated genotype A continues to be detected. Conclusions The evidence of low incidence during 2020–2021 and virological surveillance data in this study confirm that China is currently approaching measles elimination.
    Type of Medium: Online Resource
    ISSN: 1058-4838 , 1537-6591
    RVK:
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 2002229-3
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  • 8
    Online Resource
    Online Resource
    Oxford University Press (OUP) ; 2017
    In:  Journal of Insect Science Vol. 17, No. 4 ( 2017-07-01)
    In: Journal of Insect Science, Oxford University Press (OUP), Vol. 17, No. 4 ( 2017-07-01)
    Type of Medium: Online Resource
    ISSN: 1536-2442
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2017
    detail.hit.zdb_id: 2049098-7
    SSG: 12
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  • 9
    Online Resource
    Online Resource
    Oxford University Press (OUP) ; 2024
    In:  Journal of Computational Design and Engineering
    In: Journal of Computational Design and Engineering, Oxford University Press (OUP)
    Abstract: The hunger games search algorithm (HGS) is a newly proposed meta-heuristic algorithm that emulates hunger-driven foraging behaviors in a population. It combines fitness values to determine individual weights and updates them based on fitness value size, resulting in high adaptability and effective optimization. However, HGS faces issues like low convergence accuracy and susceptibility to local optima in complex optimization problems. To address these problems, an improved version called BDFXHGS is introduced. BDFXHGS incorporates a collaborative feeding strategy based on HGS's design advantages. Individuals approach others based on hunger degree, facilitating information exchange and resolving convergence and accuracy issues. BDFXHGS combines a disperse foraging strategy and a directional crossover strategy to enhance exploration and convergence speed. The paper conducts qualitative analysis and ablation experiments to examine the effectiveness of the strategies. Comparative experiments are performed using IEEE CEC 2017 benchmark functions to compare BDFXHGS with competitive algorithms, including previous champion algorithms in different dimensions. Additionally, BDFXHGS is evaluated on 25 constrained optimization problems from the IEEE CEC 2020 competition and 5 real engineering optimization problems. Experimental results show that BDFXHGS performs well on benchmarks and outperforms other algorithms in real-world applications.
    Type of Medium: Online Resource
    ISSN: 2288-5048
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2024
    detail.hit.zdb_id: 2821811-5
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  • 10
    Online Resource
    Online Resource
    Oxford University Press (OUP) ; 2022
    In:  Journal of Experimental Botany Vol. 73, No. 11 ( 2022-06-02), p. 3477-3495
    In: Journal of Experimental Botany, Oxford University Press (OUP), Vol. 73, No. 11 ( 2022-06-02), p. 3477-3495
    Abstract: The production of Arabidopsis seed mucilage involves complex polysaccharide biosynthetic pathways and developmental processes in seed epidermal cells. Although the polysaccharide components of Arabidopsis seed mucilage have been identified, their regulatory mechanism requires further investigation. Here, we show that Class II KNOX gene family members KNAT3 and KNAT7 play an essential role in regulating mucilage production in the early developmental stages of Arabidopsis seeds. Double mutant knat3knat7 resulted in defective seed mucilage production and columellae formation, whereas knat3 showed a normal phenotype compared with wild type, and the mucilage thickness in knat7 was slightly disturbed. Rhamnogalacturonan I (RG-I) and its biosynthetic substrates galacturonic acid and rhamnose were reduced in both the adherent and soluble mucilage of knat3knat7. Comparative transcriptome analysis on whole seeds suggested that polysaccharide, glucosinolate and anthocyanin biosynthetic pathways were specifically repressed in knat3knat7. Transient co-expression of KNAT3 and KNAT7 with promoter regions of candidate genes in Arabidopsis protoplasts revealed that both KNAT3 and KNAT7 act as positive regulators of the RG-I biosynthetic gene MUCILAGE-MODIFIED 4 (MUM4, AT1G53500). Collectively, our results demonstrate that KNAT3 and KNAT7 are multifunctional transcription factors in secondary cell wall development and redundantly modulate mucilage biosynthesis in Arabidopsis seeds.
    Type of Medium: Online Resource
    ISSN: 0022-0957 , 1460-2431
    RVK:
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 1466717-4
    SSG: 12
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